Learn about Reyvow side effects including dizziness, fatigue, and driving restrictions. Know which side effects are common and when to seek medical help.
Reyvow (lasmiditan) is a prescription medication used for the acute treatment of migraine with or without aura in adults. Like all medications, it comes with potential side effects. Knowing what to expect — and when something needs medical attention — helps you use Reyvow safely.
Important context: Eli Lilly is permanently discontinuing Reyvow, with U.S. distribution ending May 31, 2026. If you're currently taking Reyvow, understanding its side effect profile can help you and your doctor decide whether to continue using remaining supply or transition to an alternative.
The following side effects were reported in clinical trials. Most are mild to moderate and resolve on their own within a few hours:
Dizziness is the most commonly reported side effect of Reyvow. It can range from mild lightheadedness to a feeling of being unsteady on your feet. This typically starts within 30 minutes to 1 hour after taking the medication and usually resolves within a few hours.
What to do: Sit or lie down until the dizziness passes. Do not stand up quickly. Do not drive or operate heavy machinery.
Feeling tired or having low energy after taking Reyvow is common. This may overlap with migraine-related fatigue, making it hard to tell apart.
What to do: Rest if possible. Plan to take Reyvow when you can stay home or in a safe environment for several hours.
Reyvow affects the central nervous system and can cause significant drowsiness. This is why the FDA requires a specific warning about driving impairment.
What to do: Do not drive or operate machinery for at least 8 hours after taking Reyvow, even if you feel alert. This is a strict FDA requirement, not a suggestion.
Some patients experience tingling, prickling, or numbness in their hands, feet, or face after taking Reyvow. This is a known neurological effect of the medication.
What to do: This usually resolves on its own within a few hours. If it persists beyond 24 hours or is severe, contact your doctor.
Nausea can occur after taking Reyvow. Since nausea is also a common migraine symptom, it may be difficult to determine whether it's from the medication or the migraine itself.
What to do: Take Reyvow with a small amount of food if nausea is a recurring issue. Stay hydrated. If nausea is severe or leads to vomiting, contact your doctor.
Some patients report feeling weak or having less muscle strength after taking Reyvow. This is usually temporary.
What to do: Rest and avoid physical activity until the weakness passes. This effect should resolve within several hours.
A general feeling of sluggishness or mental fogginess can occur. Combined with drowsiness and fatigue, this is part of why the 8-hour driving restriction exists.
While most Reyvow side effects are manageable, some require immediate medical attention:
This is a rare but potentially life-threatening condition that can occur when Reyvow is taken with other serotonergic medications (such as SSRIs, SNRIs, or tricyclic antidepressants).
Symptoms to watch for:
What to do: Seek emergency medical care immediately if you experience these symptoms. Serotonin syndrome can be fatal if untreated.
Although rare, serious allergic reactions to Reyvow have been reported.
Symptoms to watch for:
What to do: Call 911 or go to the nearest emergency room immediately.
Reyvow can cause central nervous system depression, especially when combined with alcohol or other CNS depressants. This goes beyond normal drowsiness.
Symptoms to watch for:
What to do: Contact your doctor or seek medical attention. Avoid alcohol entirely when taking Reyvow.
Using any acute migraine medication — including Reyvow — too frequently can lead to medication overuse headache (MOH). This means the medication itself starts causing headaches.
Signs of MOH:
What to do: Talk to your doctor. They may recommend limiting Reyvow use to no more than 8–10 days per month and exploring preventive migraine treatments.
This deserves its own section because it's one of the most important safety considerations with Reyvow. The FDA requires that patients do not drive or operate machinery for at least 8 hours after taking a dose.
In clinical studies, Reyvow impaired driving ability even when patients felt they were fine to drive. This is similar to the way alcohol can impair driving before a person feels "drunk."
Practical tips:
One reason some patients choose Reyvow over triptans is that Reyvow doesn't cause vasoconstriction — narrowing of blood vessels. This makes it safer for people with cardiovascular risk factors. However, Reyvow's CNS side effects (dizziness, drowsiness, driving restriction) are more pronounced than those of newer CGRP-based alternatives like Ubrelvy, Nurtec ODT, or Zavzpret.
With Reyvow being discontinued, now is a good time to discuss your full range of options with your doctor. For a deeper look at what Reyvow is and how it's used, see our complete guide.
Reyvow's most common side effects — dizziness, drowsiness, fatigue, and tingling — are usually mild and temporary. The most important safety rule is the 8-hour driving restriction. Serious side effects like serotonin syndrome are rare but require immediate medical attention, especially if you take other serotonergic medications.
Since Reyvow is being permanently discontinued, talk to your doctor about your long-term migraine treatment plan. If you still need to fill a Reyvow prescription, MedFinder can help you find pharmacies with remaining stock.
You focus on staying healthy. We'll handle the rest.
Try Medfinder Concierge FreeMedfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.
%2C%20Color%3DOriginal.png)
