Comprehensive medication guide to Metoprolol including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$10 copay for generic on most Tier 1 insurance plans; $10–$20 on Tier 2. Prior authorization is generally not required for generic metoprolol. Brand-name Toprol-XL or Lopressor may be on higher tiers.
Estimated Cash Pricing
$4–$18 retail for generic metoprolol tartrate (30-day supply); $12–$65 for generic metoprolol succinate ER. As low as $2–$4 (tartrate) or $11–$12 (succinate) with GoodRx or SingleCare coupons.
Medfinder Findability Score
88/100
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Metoprolol is a prescription beta-blocker used to treat several cardiovascular conditions, including high blood pressure (hypertension), chest pain (angina pectoris), heart failure with reduced ejection fraction (HFrEF), and to reduce mortality after a heart attack. It is one of the most commonly prescribed medications in the United States.
Metoprolol is available in two distinct salt forms that are not interchangeable: metoprolol tartrate (immediate-release, brand name Lopressor) and metoprolol succinate (extended-release, brand name Toprol-XL; also available as Kapspargo Sprinkle capsules). Only metoprolol succinate is approved for heart failure.
Off-label uses include migraine prevention, atrial fibrillation rate control, essential tremor, and management of hyperthyroidism or thyroid storm. Generic versions of both forms are widely available and are significantly more affordable than brand-name versions.
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Metoprolol is a selective beta-1 adrenergic receptor blocker. It works by occupying beta-1 receptors on the heart, preventing adrenaline (epinephrine) and noradrenaline from binding. This results in a slower heart rate (negative chronotropy), reduced force of contraction (negative inotropy), slower electrical conduction through the AV node, and lower blood pressure.
Unlike non-selective beta-blockers (such as propranolol), metoprolol preferentially targets beta-1 receptors in the heart rather than beta-2 receptors in the lungs. This cardioselectivity makes it safer for patients with asthma or COPD, though the selectivity is not absolute at higher doses.
Metoprolol is metabolized in the liver by the CYP2D6 enzyme. Drugs that inhibit CYP2D6 — including fluoxetine (Prozac), paroxetine (Paxil), and bupropion (Wellbutrin) — can significantly increase metoprolol blood levels, amplifying its effects and side effects. Genetic variation in CYP2D6 also affects how quickly individuals metabolize the drug.
25 mg — tablet (tartrate, immediate-release)
Starting dose for hypertension; also used in heart failure titration
50 mg — tablet (tartrate, immediate-release)
Common maintenance dose for hypertension and angina
100 mg — tablet (tartrate, immediate-release)
Standard maintenance dose; max for most indications up to 450 mg/day total
25 mg — tablet (succinate, extended-release)
Starting dose for heart failure or hypertension with once-daily dosing
50 mg — tablet (succinate, extended-release)
Common maintenance dose for hypertension; titration step for heart failure
100 mg — tablet (succinate, extended-release)
Standard dose for hypertension and angina; titration dose for heart failure
200 mg — tablet (succinate, extended-release)
Maximum approved dose for hypertension; target dose in heart failure titration
1 mg/mL — injection (tartrate, IV)
Hospital use only for acute MI; 5 mg IV every 2 minutes x 3 doses as tolerated
Metoprolol is generally widely available and not on any FDA drug shortage list as of 2026. It receives a findability score of 88/100 — meaning it is among the more accessible prescription medications. Generic metoprolol tartrate and succinate are manufactured by numerous companies and stocked at virtually all major chain pharmacies.
However, localized stock gaps do occur — particularly for less common strengths (such as 37.5 mg or 75 mg of metoprolol tartrate) or brand-name versions. Patients who use smaller independent pharmacies or live in rural areas may occasionally encounter difficulty finding their specific formulation and strength.
If your pharmacy is out of metoprolol, medfinder can call pharmacies near you to check which ones have your specific formulation and strength in stock, then text you the results. Because metoprolol cannot be stopped abruptly, finding it quickly is a genuine medical priority.
Metoprolol is not a controlled substance, so it can be prescribed by any licensed healthcare provider with prescribing authority. No special DEA registration is required. The prescribing clinician will make the determination based on the patient's diagnosis, comorbidities, and medication history.
Telehealth providers can also prescribe metoprolol in all 50 states. Because it is not a controlled substance, no in-person visit is required by federal law. Platforms such as Teladoc, MDLive, and insurance-based virtual care services can evaluate and prescribe metoprolol for hypertension and other appropriate indications after a telehealth consultation.
No. Metoprolol is not a controlled substance and has no DEA scheduling. It is classified as a standard prescription medication, not a controlled drug. This means it can be prescribed by any licensed healthcare provider — including nurse practitioners, physician assistants, and telehealth providers — without any special DEA registration or controlled substance prescribing authority.
Prescriptions for metoprolol can be sent electronically or on paper, refilled without restrictions, and filled at any licensed pharmacy. There are no federal refill limits, early fill restrictions, or quantity limits imposed by law (though individual insurance plans may have quantity limits). Metoprolol is commonly prescribed for long-term, often lifelong maintenance therapy.
Most patients tolerate metoprolol well. The most common side effects, particularly at the start of therapy or after dose increases, include:
Serious side effects requiring immediate medical attention:
Critical warning: Never stop metoprolol abruptly. Abrupt discontinuation can trigger rebound angina, heart attack, or dangerous arrhythmias. Always taper under a doctor's guidance over 1-2 weeks.
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Carvedilol (Coreg)
Non-selective beta-blocker with alpha-1 blockade; preferred for HFrEF when additional BP reduction is needed; avoid in asthma/COPD
Atenolol (Tenormin)
Cardioselective beta-1 blocker; once daily; water-soluble so fewer CNS side effects; not for heart failure or pregnancy
Bisoprolol (Zebeta)
Highly cardioselective beta-1 blocker; once daily; AHA-recommended for HFrEF; no brand name currently marketed
Propranolol (Inderal)
Non-selective beta-blocker; useful for migraine prevention, tremor, and hyperthyroidism; avoid in asthma/COPD
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Fluoxetine (Prozac)
majorPotent CYP2D6 inhibitor; can double or triple metoprolol plasma levels, causing excessive bradycardia and hypotension
Paroxetine (Paxil)
majorPotent CYP2D6 inhibitor; similar risk to fluoxetine; significant bradycardia risk when combined with metoprolol
Amiodarone (Cordarone)
majorCYP2D6 inhibitor with additive bradycardia and AV block effects; high-risk combination requiring close monitoring
Diltiazem / Verapamil
majorCalcium channel blockers with additive heart rate-slowing and blood pressure-lowering effects; risk of severe bradycardia or heart block
Clonidine
majorAbrupt clonidine withdrawal while on metoprolol can cause severe rebound hypertension; taper clonidine carefully
Digoxin (Lanoxin)
moderateAdditive slowing of heart rate; combination used clinically for heart failure and Afib but requires monitoring
NSAIDs (ibuprofen, naproxen)
moderateReduce metoprolol's antihypertensive effect; may increase cardiovascular risk; use acetaminophen when possible
Bupropion (Wellbutrin)
moderateModerate CYP2D6 inhibitor; may significantly increase metoprolol levels and side effects
Insulin / Sulfonylureas
moderateMetoprolol masks tachycardia symptom of hypoglycemia; careful blood sugar monitoring required in diabetic patients
Epinephrine (EpiPen)
moderateMetoprolol blunts cardiovascular effects of epinephrine; larger doses may be needed in anaphylaxis; always carry EpiPen
Metoprolol is a proven, well-established medication that has improved outcomes for millions of patients with heart disease, hypertension, and heart failure. As a widely available generic, it is among the most accessible and affordable cardiovascular medications in the world. For most patients, it is a lifelong maintenance medication taken daily.
The most important thing to remember: never stop metoprolol suddenly. Any changes to your therapy must be done under a doctor's supervision with a gradual taper. If you experience side effects, report them to your provider — there may be adjustments or alternatives that improve your experience while maintaining therapeutic benefit.
If you ever have trouble finding metoprolol at your pharmacy, medfinder can help you locate it quickly near you. Given that metoprolol is a critical daily medication for most patients who take it, having a plan to find it when your pharmacy is out is an important part of staying on top of your heart health.
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