Comprehensive medication guide to Jantoven including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$10 copay for generic warfarin (Tier 1 on most commercial and Medicare Part D plans); brand-name Jantoven may be on Tier 2–3 with higher copays or require prior authorization; Medicare Extra Help eligible patients may pay $0–$3/month.
Estimated Cash Pricing
$4–$16 retail for generic warfarin sodium; brand-name Jantoven approximately $15–$22 for a 30-day supply; as low as $2.49 with a GoodRx coupon (generic) or $6.16 (Jantoven brand) at competitive pharmacies.
Medfinder Findability Score
90/100
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Jantoven is the brand name for warfarin sodium tablets, manufactured by Upsher-Smith Laboratories and available in strengths from 1 mg to 10 mg. It belongs to the drug class known as vitamin K antagonists (VKA) or coumarins. Jantoven was first FDA-approved in 1954 and remains one of the most widely prescribed anticoagulants in the United States.
Jantoven is prescribed to treat and prevent blood clots in conditions including deep vein thrombosis (DVT), pulmonary embolism (PE), atrial fibrillation (AFib), mechanical heart valve disease, and post-heart-attack anticoagulation. It is also used to prevent blood clots following orthopedic surgeries such as hip or knee replacement.
Generic warfarin sodium — bioequivalent to Jantoven — is available from multiple manufacturers and is among the most affordable prescription medications in the U.S., often costing just $2 to $5 per month with a prescription discount coupon.
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Jantoven (warfarin sodium) works by blocking the Vitamin K Epoxide Reductase (VKOR) enzyme in the liver. This enzyme recycles vitamin K into its active form, which the liver needs to produce clotting factors II (prothrombin), VII, IX, and X, and the anticoagulant proteins C and S.
When warfarin blocks VKOR, the liver cannot produce sufficient active clotting factors. As existing clotting factors naturally break down over 4 to 60 hours, the blood's clotting ability decreases — reducing the risk of dangerous clot formation in veins, arteries, or on artificial heart valves. It takes 3 to 5 days for full therapeutic anticoagulation to be established after starting warfarin.
Because the effects are indirect and influenced by many factors — including diet, other medications, illness, and genetic variations in the CYP2C9 and VKORC1 genes — Jantoven requires regular INR blood test monitoring to keep the dose within the therapeutic range (typically INR 2.0–3.0). INR above 4.0 significantly increases bleeding risk without additional clot-prevention benefit.
1 mg — tablet
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2 mg — tablet
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2.5 mg — tablet
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3 mg — tablet
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4 mg — tablet
Color-coded blue tablet
5 mg — tablet
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6 mg — tablet
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7.5 mg — tablet
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10 mg — tablet
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Jantoven is not currently in an official FDA drug shortage. Generic warfarin sodium is widely manufactured by multiple companies and is generally available at virtually every U.S. pharmacy. Jantoven brand-name tablets, however, are not stocked at many pharmacies because most dispense the lower-cost generic by default.
Patients needing the Jantoven brand may need to call ahead or use medfinder to locate pharmacies near them that stock the brand. medfinder calls pharmacies on your behalf and texts you the results — saving time and preventing dangerous therapy gaps.
Because warfarin has a narrow therapeutic range, patients should never skip doses while searching for supply. Contact your prescriber or anticoagulation clinic immediately if you cannot locate your medication.
Jantoven (warfarin sodium) is not a controlled substance and does not require DEA scheduling authorization to prescribe. Any licensed prescriber with prescribing authority can order Jantoven. The following provider types commonly manage warfarin therapy:
Primary care physicians (PCPs) — commonly manage long-term warfarin for stable AFib, DVT/PE history
Cardiologists — prescribe for AFib, mechanical heart valves, and post-MI anticoagulation
Hematologists — manage complex anticoagulation including APLS and recurrent VTE
Internal medicine physicians — manage complex patients with multiple comorbidities requiring anticoagulation
Nurse practitioners (NPs) and physician assistants (PAs) — can independently prescribe in most states; commonly staff anticoagulation clinics
Vascular and cardiac surgeons — initiate warfarin after procedures involving heart valves, blood vessels, or orthopedic surgery
Since Jantoven is not a controlled substance, telehealth providers can prescribe it in most states. However, warfarin requires ongoing INR monitoring, so patients must have access to a local laboratory or home INR device. Many patients use a hybrid model: telehealth for prescription management and local labs or anticoagulation clinics for INR monitoring.
No. Jantoven (warfarin sodium) is not a controlled substance and is not scheduled under the Controlled Substances Act by the DEA. It does not require a DEA license to prescribe and is not subject to controlled substance refill restrictions.
This means Jantoven can be prescribed by any licensed prescriber, including primary care physicians, cardiologists, nurse practitioners, and physician assistants. Telehealth providers can also prescribe Jantoven in most states. However, because warfarin requires frequent INR monitoring, patients need access to lab testing — through a local clinic, hospital, or home INR device.
Standard prescriptions can be written for up to a 90-day supply for patients who are stable on therapy. Jantoven can be called in to a pharmacy (it does not require a written prescription as controlled substances do in many states), and refills can be authorized by phone or electronically.
Jantoven carries an FDA Boxed Warning for major or fatal bleeding. Common and manageable side effects include:
Easy bruising and prolonged bleeding from cuts
Nosebleeds (epistaxis)
Heavier menstrual periods
Nausea, vomiting, diarrhea, or stomach pain
Hair loss (usually temporary)
Skin rash or itching
Major or fatal internal hemorrhage (any organ)
Intracranial hemorrhage (sudden severe headache, confusion, vision changes)
Gastrointestinal bleeding (black/tarry stools, vomiting blood)
Skin and tissue necrosis (within first days of therapy — especially with protein C deficiency)
Purple toe syndrome (cholesterol microemboli causing painful discoloration)
Hepatitis, elevated liver enzymes
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Apixaban (Eliquis)
Direct Factor Xa inhibitor DOAC; no INR monitoring required; lower bleeding risk than warfarin; no dietary restrictions; twice-daily dosing; not appropriate for mechanical heart valves; significantly higher cost (generic now available).
Rivaroxaban (Xarelto)
Direct Factor Xa inhibitor DOAC; once-daily dosing (convenient); no INR monitoring; generic available; higher GI bleeding risk than apixaban; not for mechanical valves.
Dabigatran (Pradaxa)
Direct thrombin inhibitor DOAC; twice-daily dosing; no INR monitoring; higher GI side effects; idarucizumab reversal agent available; 80% renally eliminated; generic available.
Edoxaban (Savaysa)
Direct Factor Xa inhibitor DOAC; once-daily; requires initial parenteral anticoagulation; less effective in AFib patients with CrCl >95 mL/min; approved for DVT/PE and AFib.
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Amiodarone (Cordarone)
majorMajor CYP2C9 inhibitor — can increase INR by 30-50%. Requires significant warfarin dose reduction and close INR monitoring when starting or stopping amiodarone.
Fluconazole (Diflucan)
majorStrong CYP2C9 inhibitor that significantly increases warfarin levels and INR. INR should be monitored closely when antifungal is initiated.
Rifampin
majorPotent CYP inducer that dramatically reduces warfarin effectiveness. Often requires 2–5x normal warfarin dose when used concomitantly. INR drops sharply.
NSAIDs (ibuprofen, naproxen)
majorIncrease bleeding risk by inhibiting platelet aggregation and potentially causing GI mucosal injury. Should be avoided with warfarin when possible.
St. John's Wort
majorPotent CYP enzyme inducer that significantly reduces warfarin levels and anticoagulant effect. Must be avoided with warfarin therapy.
Metronidazole (Flagyl)
moderateCYP2C9 inhibitor that increases warfarin levels and INR. INR monitoring required when metronidazole is started or stopped.
Ciprofloxacin
moderateCYP1A2 inhibitor that can increase warfarin effect. INR should be monitored during and after antibiotic courses.
CBD (Cannabidiol)
moderateInhibits CYP2C9 metabolism of warfarin, significantly increasing warfarin blood levels and INR. Close monitoring required if used together.
Carbamazepine (Tegretol)
moderateCYP enzyme inducer that reduces warfarin effectiveness. Warfarin dose increases needed when carbamazepine is initiated.
Vitamin K-rich foods (kale, spinach, broccoli)
minorConsistent intake is critical — sudden increases reduce warfarin effect (lower INR); sudden decreases raise INR. Maintain consistent dietary vitamin K intake.
Jantoven (warfarin sodium) has been protecting patients from life-threatening blood clots for over 70 years. Despite the emergence of newer anticoagulants (DOACs), warfarin remains irreplaceable for patients with mechanical heart valves, antiphospholipid syndrome, and certain other conditions. Its extremely low cost (generic warfarin as little as $2–$5/month) also makes it a first-line option where cost is a barrier to DOAC therapy.
The primary challenge for Jantoven patients is that the brand-name product is not stocked by most pharmacies, which default to generic warfarin. While generic is typically appropriate and cost-effective, patients who need the brand must plan ahead to ensure consistent supply.
If you're having trouble finding Jantoven at your pharmacy, medfinder calls local pharmacies on your behalf and texts you which ones have your medication in stock. It's a fast, convenient way to ensure you never miss a dose of this life-critical medication.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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