Comprehensive medication guide to Femring including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$30–$75 copay with most plans; prior authorization or step therapy through lower-cost vaginal estrogen products may be required.
Estimated Cash Pricing
$895–$1,100 per ring (3-month supply) without insurance; discount cards may offer limited savings but this brand-name product has no generic alternative.
Medfinder Findability Score
55/100
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Femring is a prescription estradiol acetate vaginal ring used to treat moderate-to-severe menopausal symptoms. Unlike low-dose vaginal estrogen products that only address local vaginal symptoms, Femring delivers systemic levels of estrogen, making it effective for both vasomotor symptoms (hot flashes and night sweats) and vulvar/vaginal atrophy (dryness, irritation, and painful intercourse).
Each ring is inserted into the vagina and left in place for 3 months before being replaced. Femring is manufactured by Millicent Pharma and is available only as a brand-name product — no generic version currently exists.
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Femring contains estradiol acetate, which is steadily released from the vaginal ring and absorbed through the vaginal walls. Once absorbed, estradiol acetate is converted into estradiol — the primary form of estrogen produced by the ovaries before menopause. Estradiol binds to estrogen receptors throughout the body, restoring hormone levels that naturally decline during menopause.
Because Femring delivers systemic estrogen levels (unlike low-dose vaginal estrogen rings like Estring), it can relieve both local symptoms like vaginal dryness and systemic symptoms like hot flashes. The ring provides continuous, steady-state delivery over its 3-month lifespan, avoiding the peaks and valleys associated with oral estrogen pills.
0.05 mg/day vaginal ring
contains 12.4 mg estradiol acetate; releases 0.05 mg of estradiol per day over 3 months
0.10 mg/day vaginal ring
contains 24.8 mg estradiol acetate; releases 0.10 mg of estradiol per day over 3 months
Femring scores a 55 out of 100 on our findability scale, meaning it can be moderately difficult to locate. While Femring is not currently listed on the FDA Drug Shortages database, it is a niche brand-name product with no generic equivalent. Many local pharmacies do not routinely stock it due to its high cost and low demand volume. Patients frequently report needing to call multiple pharmacies or wait for special orders. Ownership changes — from Warner Chilcott to Allergan to Millicent Pharma — have occasionally disrupted distribution consistency.
If your local pharmacy doesn't have Femring in stock, consider using Medfinder to search for pharmacies that currently have it available near you.
Femring is most commonly prescribed by:
Telehealth consultations are also available for Femring prescriptions, which can be convenient if you're having difficulty finding a local prescriber experienced with this medication.
No, Femring is not a controlled substance. It is not scheduled by the DEA and does not have abuse potential. However, it is a prescription-only medication and requires a valid prescription from a licensed healthcare provider. Femring carries an FDA boxed warning regarding risks of endometrial cancer, cardiovascular disorders, breast cancer, and probable dementia — so it should only be used under medical supervision.
Serious but less common side effects include blood clots, stroke, heart attack, and increased risk of endometrial or breast cancer with long-term use. Contact your doctor immediately if you experience chest pain, sudden severe headache, vision changes, unusual vaginal bleeding, or signs of a blood clot (leg swelling, warmth, or redness).
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Estring
A low-dose estradiol vaginal ring (0.0075 mg/day) that treats local vaginal symptoms only. Does not provide systemic estrogen for hot flashes. Replaced every 90 days.
Vagifem / Yuvafem
Estradiol vaginal tablets (10 mcg) for vulvar and vaginal atrophy. Yuvafem is the generic version and may be more affordable.
Imvexxy
Estradiol vaginal inserts (4 mcg or 10 mcg) for vaginal atrophy symptoms. Brand-name only.
Premarin Vaginal Cream
Conjugated estrogens cream for atrophic vaginitis. Available in brand and generic forms.
Oral or transdermal estrogen
Estradiol pills or patches (such as Vivelle-Dot, Climara) can address systemic menopausal symptoms if the vaginal ring format is not preferred.
Prefer Femring? We can find it.
CYP3A4 inducers
moderate(St. John's Wort, Carbamazepine, Phenobarbital, Rifampin) — may decrease estrogen levels and reduce Femring's effectiveness
CYP3A4 inhibitors
moderate(Ritonavir, Ketoconazole, Erythromycin) — may increase estrogen levels and side effect risk
Anticoagulants
moderate(Warfarin) — estrogen may affect blood clotting
Thyroid medications
moderateestrogen may increase thyroid-binding globulin, potentially requiring thyroid dose adjustments
Grapefruit juice
moderatemay increase estrogen levels through CYP3A4 inhibition
Femring fills a unique niche as the only vaginal ring that delivers systemic estrogen levels — making it a valuable option for women who need relief from both hot flashes and vaginal atrophy symptoms without taking daily pills or wearing patches. However, its brand-only status and limited pharmacy stocking can make it challenging to find and expensive without good insurance coverage.
At $895–$1,100 per ring without insurance, cost is a significant barrier for many patients. If your insurance covers Femring, expect prior authorization requirements in many cases. For patients struggling to find Femring in stock, Medfinder can help locate pharmacies that currently have it available. If cost or availability remain obstacles, talk to your doctor about alternative estrogen delivery methods that may be more accessible.
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