Comprehensive medication guide to Dayvigo including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$30 copay with Eisai savings card (for eligible commercially insured patients); varies by plan
Estimated Cash Pricing
$294–$445 retail; as low as $135 with GoodRx coupon
Medfinder Findability Score
72/100
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Dayvigo (lemborexant) is a prescription sleep medication used to treat insomnia in adults, manufactured by Eisai Inc. It was FDA-approved in December 2019 and is indicated for the treatment of insomnia characterized by difficulty with sleep onset and/or sleep maintenance.
Dayvigo belongs to a class of medications called dual orexin receptor antagonists (DORAs) — a newer approach to treating insomnia that works differently from older sleep medications like benzodiazepines or "Z-drugs" (zolpidem, eszopiclone). Instead of broadly sedating the brain, DORAs specifically block the wakefulness signals that keep you alert.
Dayvigo is a Schedule IV controlled substance, meaning it has some potential for dependence, though studies suggest lower abuse potential compared to benzodiazepines and Z-drugs.
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Dayvigo works by blocking orexin receptors in the brain. Orexins (also called hypocretins) are neuropeptides produced in the hypothalamus that play a central role in keeping you awake and alert. By blocking both the orexin-1 (OX1R) and orexin-2 (OX2R) receptors, Dayvigo essentially turns down your brain's wakefulness signals, allowing sleep to occur naturally.
This is fundamentally different from older sleep medications. Benzodiazepines and Z-drugs (like Ambien) work by enhancing GABA activity, which broadly sedates the central nervous system. Dayvigo's targeted approach — blocking only the wake-promoting orexin system — may result in a more natural sleep architecture with potentially fewer side effects like next-day grogginess.
Dayvigo reaches peak blood concentration in 1 to 3 hours and has an elimination half-life of approximately 17 to 19 hours. Despite the long half-life, clinical studies showed that next-day impairment was generally mild at the recommended 5 mg dose. Dayvigo has a stronger affinity for OX2R, which is more directly involved in sleep-wake regulation.
Notably, studies have shown no evidence of rebound insomnia or withdrawal symptoms when discontinuing Dayvigo after 30-day and 6-month trials, which is a meaningful advantage over some older insomnia medications.
5 mg tablets
recommended starting dose for most adults
10 mg tablets
maximum recommended dose, for patients who tolerate 5 mg but need greater efficacy
Starting dose
5 mg once nightly, taken immediately before bedtime
Maximum dose
10 mg once nightly
Patients over 65
Use caution at doses above 5 mg
Moderate hepatic impairment
Do not exceed 5 mg nightly
Patients on weak CYP3A inhibitors
Do not exceed 5 mg nightly
Dayvigo (lemborexant) is a brand-name prescription sleep medication, and we've assigned a findability score of 72 out of 100. While Dayvigo is not currently on the FDA shortage list and is manufactured in adequate supply by Eisai, its brand-only status and relatively niche prescribing patterns mean not every pharmacy keeps it on the shelf.
Dayvigo has no generic version — it's a brand-only medication with a list price of $294 for a 30-day supply. Some pharmacies, especially independents, may not stock it routinely due to lower demand compared to older sleep medications like zolpidem (Ambien) or trazodone. Pharmacies tend to stock what's most commonly prescribed, and Dayvigo is still building market share as a newer drug class.
Because it's a Schedule IV controlled substance, Dayvigo requires a prescription and may have ordering lead times at pharmacies that don't regularly carry it. However, most major chain pharmacies (CVS, Walgreens, Walmart) can order it within 1–2 business days.
Unlike acute-need medications, insomnia treatment allows some planning time. If your pharmacy doesn't have Dayvigo in stock, request they order it or check nearby pharmacies. Medfinder can help you quickly locate pharmacies with Dayvigo in stock near you.
Any licensed prescriber can prescribe Dayvigo, including:
As a Schedule IV controlled substance, Dayvigo requires a prescription but does not have the same prescribing restrictions as Schedule II medications. Many telehealth platforms can also prescribe Dayvigo for insomnia after an appropriate evaluation.
Medfinder helps you find pharmacies with Dayvigo in stock.
Yes, Dayvigo is a Schedule IV controlled substance under the Controlled Substances Act. This is the same classification as other sleep medications like zolpidem (Ambien), eszopiclone (Lunesta), and the other DORA, suvorexant (Belsomra).
Schedule IV means the drug has a lower potential for abuse relative to Schedule III substances. Clinical studies of lemborexant showed low abuse potential, and there is no evidence of physical dependence or withdrawal symptoms at recommended doses. However, as with all controlled substances, prescriptions cannot be transferred between pharmacies in some states, and refill policies may vary.
Side effects are generally dose-dependent — the 5 mg dose is better tolerated than 10 mg. Most side effects are mild and tend to improve with continued use.
As a CNS depressant with a 17–19 hour half-life, Dayvigo can impair next-day driving and activities. This risk increases at the 10 mg dose. Patients should ensure at least 7 hours of sleep before activities requiring full alertness.
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Suvorexant (Belsomra)
The first FDA-approved DORA (2014). Same drug class as Dayvigo. Available in 5 mg, 10 mg, 15 mg, and 20 mg doses. Also brand-only with similar pricing.
Zolpidem (Ambien) — Generic available
The most commonly prescribed sleep medication. Available as immediate-release and extended-release (Ambien CR). Generic costs as low as $5–$15. Works on GABA receptors.
Eszopiclone (Lunesta) — Generic available
Another GABA-based sleep medication. Generic available at lower cost.
Zaleplon (Sonata) — Generic available
Very short-acting, best for sleep onset difficulty only.
Trazodone — Generic available
Antidepressant widely used off-label for insomnia. Very inexpensive ($4–$10). Sedating at low doses.
Doxepin (Silenor) — Generic available
Low-dose tricyclic antidepressant FDA-approved for sleep maintenance insomnia.
Ramelteon (Rozerem) — Generic available
Melatonin receptor agonist. Not a controlled substance. Good for sleep onset difficulty.
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Strong CYP3A inhibitors
moderate(itraconazole, clarithromycin, ketoconazole) — significantly increase Dayvigo levels, raising risk of adverse effects. Do not use together.
Strong CYP3A inducers
moderate(rifampin, carbamazepine, St. John's wort) — significantly reduce Dayvigo effectiveness. Avoid combination.
Alcohol
moderateincreases CNS depression and impairment. Do not consume alcohol with Dayvigo.
Moderate CYP3A inhibitors
moderate(fluconazole, verapamil, diltiazem, erythromycin) — may increase Dayvigo levels. Avoid concurrent use or monitor closely.
Moderate CYP3A inducers
moderate(bosentan, efavirenz, modafinil) — may decrease Dayvigo effectiveness.
Weak CYP3A inhibitors
moderatelimit Dayvigo dose to 5 mg nightly when co-administered.
Other CNS depressants
moderate(benzodiazepines, opioids, other sleep aids, sedating antihistamines) — additive sedation risk. Use caution and consider dose reduction.
Food/meals
moderatetaking Dayvigo with or immediately after eating can delay onset of action. Take on an empty stomach at bedtime.
Dayvigo represents a newer, targeted approach to treating insomnia that works fundamentally differently from the older sleep medications many patients and providers are familiar with. By blocking orexin-driven wakefulness rather than broadly sedating the brain, it offers a more physiologically natural path to sleep with a lower risk of dependence and no rebound insomnia.
The main barriers are cost (brand-only at $294+ retail, though GoodRx coupons bring it to ~$135 and the Eisai savings card can reduce copays to $0–$30) and pharmacy stocking (not every pharmacy carries it routinely). For patients whose insomnia hasn't responded well to generic options or who want to avoid the dependence concerns associated with benzodiazepines and Z-drugs, Dayvigo is worth discussing with a provider.
Medfinder can help you find pharmacies with Dayvigo in stock near you. Search for availability.
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