Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Clorazepate (brand name Tranxene) is a benzodiazepine medication FDA-approved for three conditions: anxiety disorders, partial seizures (as add-on therapy), and acute alcohol withdrawal. It belongs to the long-acting benzodiazepine class, meaning its effects last longer than many other benzodiazepines. Clorazepate is a prodrug — it is converted in the body to its active form, Nordiazepam, which has a half-life of approximately 2 days. This long duration of action can be beneficial for maintaining steady symptom relief throughout the day.
Clorazepate is a prodrug that is rapidly converted in the stomach to its active metabolite, Nordiazepam. Nordiazepam works by enhancing the effect of gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter, at the GABA-A receptor. By increasing GABA activity, Clorazepate produces anxiolytic (anti-anxiety), anticonvulsant, sedative, and muscle relaxant effects. Because Nordiazepam has a long half-life of roughly 40–50 hours, Clorazepate provides sustained relief and may be taken less frequently than shorter-acting benzodiazepines.
Clorazepate is available as immediate-release tablets. The brand name Tranxene SD (single-dose extended-release) has been discontinued in most markets. Generic tablets in all three strengths are the most commonly dispensed form.
Clorazepate is an older, less commonly prescribed benzodiazepine, which means many pharmacies do not routinely stock it. While it is not currently listed on the FDA Drug Shortage Database, limited manufacturer interest and low patient demand can make it difficult to find at your local pharmacy. In 2026, ANI Pharmaceuticals received FDA approval for a new generic version, which may gradually improve supply. If your pharmacy doesn't have it in stock, ask them to order it or try calling independent pharmacies, which may be more willing to special-order niche medications.
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As a Schedule IV controlled substance, Clorazepate can be prescribed by any licensed physician, nurse practitioner, or physician assistant with DEA prescribing authority. The most common prescribers include:
Note: Clorazepate is generally not available via telehealth due to DEA regulations on prescribing controlled substances remotely. An in-person visit is typically required.
Yes. Clorazepate is classified as a DEA Schedule IV controlled substance, meaning it has a recognized medical use but carries a risk of abuse and dependence. All benzodiazepines, including Clorazepate, carry FDA boxed warnings regarding:
Because of these risks, prescriptions may be subject to quantity limits, refill restrictions, and prior authorization requirements by insurance plans.
Serious side effects that require immediate medical attention include respiratory depression (especially when combined with opioids or alcohol), severe sedation, paradoxical reactions (agitation, hostility), seizures from abrupt discontinuation, suicidal thoughts, and signs of allergic reaction.
If Clorazepate is unavailable or not suitable, your doctor may consider these alternatives:
Always consult your prescriber before switching medications. Each benzodiazepine has different onset times, durations of action, and approved indications.
Major interactions (avoid or use extreme caution):
Moderate interactions:
Clorazepate is an effective but niche benzodiazepine that serves an important role for patients with anxiety, partial seizures, and acute alcohol withdrawal. While it is not in active FDA shortage, its limited manufacturer base and low prescribing volume mean it may not always be readily available at your pharmacy. The good news: generic Clorazepate is affordable, often under $35 for a 30-day supply with a discount coupon, and a new generic manufacturer (ANI Pharmaceuticals) entered the market in 2026. If you're having trouble finding Clorazepate in stock, use Medfinder to locate pharmacies near you that have it available. Don't hesitate to ask your pharmacist to special-order it or to check independent pharmacies, which may be more flexible with niche medications.
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