Comprehensive medication guide to Clomiphene including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50 copay when covered; some plans exclude fertility medications or require prior authorization.
Estimated Cash Pricing
$85–$415 per cycle retail; as low as $30–$100 with GoodRx or SingleCare coupons.
Medfinder Findability Score
65/100
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Clomiphene (brand names Clomid and Serophene) is a selective estrogen receptor modulator (SERM) used primarily to treat ovulatory dysfunction in women who want to become pregnant. It is one of the most commonly prescribed fertility medications and has been a first-line treatment for ovulation induction for decades.
Clomiphene is FDA-approved for treating ovulatory dysfunction, including in women with polycystic ovary syndrome (PCOS). It is also widely used off-label in men to treat hypogonadism (low testosterone) and male infertility, as it can boost testosterone levels while preserving sperm production — unlike testosterone replacement therapy.
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Clomiphene works by blocking estrogen receptors in the hypothalamus, a key part of the brain that regulates hormone production. When these receptors are blocked, the body perceives estrogen levels as low, even though they may be normal. This triggers the pituitary gland to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
The increase in FSH stimulates the ovaries to develop one or more mature follicles (eggs), while the surge in LH triggers ovulation — the release of a mature egg. In men, the same mechanism boosts LH and FSH production, which increases testosterone levels and supports sperm production.
Treatment typically involves taking 50 mg daily for 5 days, starting on day 5 of the menstrual cycle. If ovulation does not occur, the dose may be increased to 100 mg in subsequent cycles. Most doctors recommend a maximum of 3 to 6 treatment cycles.
50 mg oral tablet — tablet
the standard dose for ovulation induction. Your doctor may prescribe 1 tablet (50 mg) or 2 tablets (100 mg) daily for 5 days per cycle.
Clomiphene scores a 65 out of 100 on our findability scale, meaning it's moderately easy to find but some pharmacies may have limited stock. After Par Pharmaceuticals discontinued its generic version and Endo Pharmaceuticals went bankrupt, Cosette Pharmaceuticals acquired the Clomid brand in late 2022 and has helped restore supply. As of early 2026, Clomiphene is generally available at most major pharmacies, though occasional stock gaps can occur due to manufacturer consolidation. If your local pharmacy is out, try calling a few others or use Medfinder to locate it nearby.
Several types of healthcare providers can prescribe Clomiphene, depending on the reason for use:
Telehealth providers also prescribe Clomiphene in many states, making it easier to access for patients who may not have a local fertility specialist.
No, Clomiphene is not a controlled substance. It is not classified under any DEA schedule, so there are no special prescribing restrictions. Your doctor can call in, fax, or e-prescribe Clomiphene to any pharmacy, and refills are straightforward. However, because it is a fertility medication, your doctor will likely want to monitor your response with ultrasounds and blood work during treatment.
Serious side effects to watch for include ovarian hyperstimulation syndrome (OHSS) — characterized by severe pelvic pain, rapid weight gain, and difficulty breathing — as well as visual disturbances (blurred vision, floaters, light sensitivity), which may require stopping the medication. There is also an increased chance of multiple pregnancies (twins or triplets). Contact your doctor immediately if you experience any of these symptoms.
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Letrozole (Femara)
an aromatase inhibitor increasingly preferred as first-line treatment for PCOS-related infertility. It does not have anti-estrogenic effects on the uterine lining, which may improve pregnancy rates.
Gonadotropins (Follistim, Gonal-F, Menopur)
injectable FSH and LH hormones for ovulation induction. More potent than Clomiphene but significantly more expensive ($1,000–$5,000+ per cycle) and carry a higher risk of multiple pregnancies.
hCG Trigger Shots (Ovidrel, Pregnyl)
injectable medications used alongside Clomiphene or Letrozole to precisely time ovulation.
Metformin
an insulin-sensitizing agent sometimes used in PCOS patients to help restore ovulation, often combined with Clomiphene for better results.
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Ospemifene
moderateboth are SERMs; concurrent use may reduce effectiveness or increase side effects
Tamoxifen
moderateboth act on estrogen receptors; combined use is not recommended
Bexarotene
moderatemay alter estrogen receptor activity
JAK inhibitors (Tofacitinib, Ruxolitinib, Baricitinib, Upadacitinib)
moderatepotential interaction with estrogen receptor signaling
Fluoroestradiol F 18
moderatemay interfere with PET imaging results
Clomiphene remains one of the most widely prescribed and affordable fertility medications available. As a time-tested oral treatment for ovulation induction, it offers a less invasive and less expensive option compared to injectable gonadotropins or IVF. While supply disruptions occurred during manufacturer transitions in 2022–2023, availability has largely stabilized as of 2026.
If you're having trouble finding Clomiphene in stock at your local pharmacy, use Medfinder to search for pharmacies near you that have it available. Discount programs like GoodRx and SingleCare can also help reduce out-of-pocket costs significantly, especially if your insurance doesn't cover fertility medications.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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