Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Bupropion XR (extended-release) is an antidepressant that belongs to the norepinephrine-dopamine reuptake inhibitor (NDRI) class. It is FDA-approved for treating Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Unlike most antidepressants, Bupropion works on dopamine and norepinephrine rather than serotonin, which gives it a unique side effect profile — it is less likely to cause weight gain or sexual dysfunction.
Bupropion is also prescribed off-label for ADHD, antidepressant-induced sexual dysfunction, and as part of combination therapies for weight management and smoking cessation. Brand-name versions include Wellbutrin XL, Aplenzin, and Forfivo XL.
Bupropion works by inhibiting the reuptake of two key neurotransmitters: norepinephrine and dopamine. By blocking the dopamine transporter (DAT) and norepinephrine transporter (NET), it increases the availability of these chemicals in the brain, which helps improve mood, energy, and concentration.
Unlike SSRIs and SNRIs, Bupropion has minimal effect on serotonin reuptake. It may also act as a nicotinic acetylcholine receptor antagonist, which contributes to its effectiveness in smoking cessation. The extended-release (XL) formulation releases the medication gradually over 24 hours, allowing for once-daily dosing.
Your doctor will typically start you at 150 mg once daily and may increase to 300 mg after about 4 days. The maximum recommended dose is 450 mg/day.
Bupropion XR (also known as Bupropion XL) has a findability score of 70 out of 100, meaning it can be moderately difficult to locate in stock at your local pharmacy. Since 2023, intermittent supply disruptions have affected certain generic manufacturers, particularly for the 300 mg extended-release strength. While many pharmacies carry Bupropion XR, you may need to call a few locations or use a tool like Medfinder to check real-time availability near you.
The shortage is driven by increased demand for mental health medications combined with manufacturing and supply chain challenges. The FDA continues to monitor the situation and work with manufacturers to restore full supply.
Struggling to find {drug} in stock? We'll call the pharmacies, sit on hold, and find you one that can fill your prescription.
Bupropion XR can be prescribed by a range of healthcare providers, including:
Bupropion XR is also widely available through telehealth platforms, making it convenient to get a prescription without an in-person visit. Use Medfinder to find a prescribing doctor near you.
No. Bupropion XR is not classified as a controlled substance by the DEA. It does not have a DEA schedule and is not subject to the prescribing restrictions that apply to controlled medications like stimulants or benzodiazepines. This means refills are generally easier to obtain, and prescriptions can often be sent electronically or called in to pharmacies without special requirements.
Most side effects of Bupropion XR are mild and tend to improve within the first few weeks of treatment. Common side effects include:
Serious side effects are rare but include seizures (risk increases at higher doses), elevated blood pressure, and severe allergic reactions. Bupropion carries an FDA boxed warning about increased risk of suicidal thoughts in young adults under 25. Contact your doctor immediately if you experience unusual mood changes, seizures, or allergic reactions.
If you're unable to find Bupropion XR in stock or it isn't the right fit, your doctor may consider these alternatives:
Always consult your prescriber before switching medications. Use Medfinder to check availability of these alternatives near you.
Bupropion XR has several important drug interactions to be aware of:
Always provide your doctor and pharmacist with a complete list of all medications, supplements, and herbs you take.
Bupropion XR remains one of the most widely prescribed antidepressants in the United States, valued for its unique mechanism of action and favorable side effect profile. While intermittent shortages since 2023 have made it harder to find at some pharmacies — especially the 300 mg strength — generic Bupropion XL is generally affordable and covered by most insurance plans.
If you're having trouble finding Bupropion XR in stock, Medfinder can help you locate pharmacies near you that have it available right now. Don't go without your medication — use the tools available to you and talk to your prescriber about alternatives if needed.
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