What is Benzphetamine and what does it do?

Benzphetamine (brand names Didrex and Regimex) is a prescription weight-loss medication classified as a sympathomimetic amine anorectic. It is approved by the FDA as a short-term adjunct to caloric restriction for weight loss in patients with a BMI of 30 or higher who have not responded to diet and exercise alone.

Benzphetamine works by suppressing appetite, making it easier to stick to a reduced-calorie diet. It is intended for use over a period of a few weeks and is typically prescribed alongside a comprehensive weight management plan that includes dietary changes and increased physical activity.

How does Benzphetamine work?

Benzphetamine is a sympathomimetic amine that stimulates the central nervous system by increasing the release of norepinephrine and dopamine in the brain. These neurotransmitters play key roles in regulating appetite and energy levels. By boosting their activity, Benzphetamine suppresses hunger signals, helping patients eat less.

While pharmacologically similar to amphetamines, Benzphetamine has a lower abuse potential compared to other stimulant-based weight loss medications, which is why it is classified as a Schedule III controlled substance rather than Schedule II.

Available doses of Benzphetamine

• 50 mg oral tablet — scored, peach-colored, round tablet (immediate-release only)

The typical dosing range is 25 to 50 mg one to three times daily, with a maximum of 150 mg per day. Your doctor will usually start you at 25 to 50 mg once daily and adjust based on your response.

How hard is it to find Benzphetamine in stock?

Benzphetamine has a findability score of 60 out of 100, meaning it can be moderately difficult to locate at your local pharmacy. While Benzphetamine is not currently listed on the FDA drug shortage database, it is an amphetamine derivative subject to DEA production quotas. The broader stimulant medication shortage that began in 2022–2023 has periodically affected availability of all Schedule II–III stimulants, including Benzphetamine.

If your regular pharmacy is out of stock, try calling independent pharmacies in your area or use Medfinder to check real-time availability near you.

What kinds of doctors prescribe Benzphetamine?

Benzphetamine is commonly prescribed by doctors who specialize in weight management, including:

• Bariatric medicine specialists
• Obesity medicine physicians
• Endocrinologists
• Internal medicine doctors
• Family medicine practitioners
• Primary care physicians

Because Benzphetamine is a controlled substance, it is not currently available through telehealth prescribing services. You will need an in-person visit with a licensed provider.

Is Benzphetamine a controlled substance?

Yes, Benzphetamine is a Schedule III controlled substance under the Controlled Substances Act. This means it has a moderate potential for physical and psychological dependence, though less than Schedule I or II drugs. As an amphetamine derivative, it is subject to DEA production quotas, which can affect supply availability.

Because of its controlled status, Benzphetamine prescriptions may have limits on refills, and your pharmacy may need to order it specially. Always take Benzphetamine exactly as prescribed and do not share it with others.

What are common side effects of Benzphetamine?

Like all medications, Benzphetamine can cause side effects. Common side effects include:

• Dry mouth
• Insomnia
• Restlessness
• Dizziness
• Headache
• Nausea
• Constipation or diarrhea
• Tremor
• Increased sweating
• Unpleasant taste
• Irritability

More serious side effects that require immediate medical attention include palpitations, rapid heartbeat, elevated blood pressure, psychotic episodes, and signs of dependence. Contact your doctor right away if you experience any concerning symptoms.

What are some alternative medications to Benzphetamine?

If you cannot find Benzphetamine in stock or if it is not the right fit for you, your doctor may consider these alternatives:

• Phentermine (Adipex-P, Lomaira) — The most commonly prescribed weight-loss stimulant, available as a Schedule IV medication in 15 mg and 37.5 mg tablets
• Diethylpropion (Tenuate) — Another sympathomimetic amine approved for short-term weight loss, classified as Schedule IV
• Phendimetrazine (Bontril) — A Schedule III medication in the same class as Benzphetamine, available in immediate and extended-release forms
• Orlistat (Xenical, Alli) — A non-stimulant option that works by blocking fat absorption; Alli is available over the counter

Does Benzphetamine interact with other drugs?

Yes, Benzphetamine has several important drug interactions to be aware of:

• MAO inhibitors — Contraindicated within 14 days due to risk of hypertensive crisis
• Other CNS stimulants — Increased risk of adverse cardiovascular and nervous system effects
• Other anorectic agents — Potential for serious cardiac problems when combined
• Antihypertensives — Benzphetamine may decrease the blood-pressure-lowering effect of these medications
• Tricyclic antidepressants — Benzphetamine may enhance the effects of TCAs
• Insulin and oral diabetes medications — Dosage adjustments may be needed
• Acidic foods and beverages — Citrus juices and vitamin C may decrease Benzphetamine absorption

Always inform your doctor and pharmacist about all medications, supplements, and vitamins you are taking before starting Benzphetamine.

Final thoughts on finding Benzphetamine

Benzphetamine is a moderately available weight-loss medication with a findability score of 60 out of 100. While not currently in a formal shortage, its status as a DEA-scheduled amphetamine derivative means supply can fluctuate based on production quotas and broader stimulant availability trends.

If your pharmacy is out of stock, don't give up. Try independent pharmacies, ask your pharmacist to check distributor availability, or use Medfinder to locate Benzphetamine in stock near you. With cash prices ranging from $70 to $625 without a discount card, it's also worth checking coupon programs like SingleCare or GoodRx to save on your prescription.