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Airsupra is a first-of-its-kind rescue inhaler that combines albuterol (a short-acting beta2-agonist or SABA) with budesonide (an inhaled corticosteroid or ICS) in a single device. It is FDA-approved for as-needed treatment or prevention of bronchoconstriction and reduction of the risk of exacerbations in adults aged 18 and older with asthma. Manufactured by AstraZeneca, Airsupra is the first rescue inhaler to include an anti-inflammatory component, providing both immediate symptom relief and inflammation control in one puff.
Airsupra works through two complementary mechanisms. Albuterol sulfate is a short-acting beta2-adrenergic agonist that rapidly relaxes the smooth muscles lining the airways, causing them to widen and making it easier to breathe. Budesonide is an inhaled corticosteroid that reduces inflammation in the lungs with each rescue use. Together, they provide both immediate bronchodilation and anti-inflammatory protection — addressing the root cause of asthma (inflammation) every time you reach for your rescue inhaler.
The standard dose is 2 inhalations (puffs) as needed, with a maximum of 12 inhalations (6 doses) per 24 hours.
Airsupra scores a 58 out of 100 on our findability scale, meaning it can be moderately difficult to locate. While Airsupra is not listed on any FDA or ASHP drug shortage databases, it's a newer brand-name medication (FDA approved January 2023) with no generic alternative. Many pharmacies simply don't stock it due to its high cost and limited demand. You may need to call several pharmacies or use Medfinder to locate one that carries it.
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Airsupra can be prescribed by several types of healthcare providers, including:
Telehealth consultations are also available for Airsupra prescriptions. If you're interested in switching from a traditional rescue inhaler to Airsupra, talk to your asthma care provider.
No, Airsupra is not a controlled substance. It does not have a DEA schedule and can be prescribed and dispensed without the additional restrictions that apply to controlled medications. You can also order it through mail-order pharmacies and online platforms like AstraZeneca Direct.
To reduce the risk of oral thrush, rinse your mouth with water and spit after each use. Contact your healthcare provider if side effects persist or become bothersome.
Always inform your doctor and pharmacist of all medications you take, including over-the-counter drugs and supplements.
Airsupra represents a significant advancement in asthma rescue treatment — it's the first inhaler to combine a fast-acting bronchodilator with an anti-inflammatory steroid in a single device. While the price tag can be steep without insurance ($479–$737), AstraZeneca's SUPRA Savings Card and AstraZeneca Direct program can significantly reduce out-of-pocket costs. The biggest challenge for patients is simply finding it in stock, as many pharmacies don't carry it yet. If your pharmacy doesn't have it, try using Medfinder to locate a pharmacy near you that does. Talk to your asthma doctor about whether Airsupra's dual-action approach is right for you.