Medications

Airsupra

Airsupra

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$0–$50 copay with commercial insurance; prior authorization or step therapy may be required, and some plans place it on a specialty tier.
Estimated Cash Pricing
$479–$737 per inhaler at retail; AstraZeneca Direct offers it for ~$249, and the SUPRA Savings Card can bring commercially insured patients' cost to $0.
Medfinder Findability Score
58
/100
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Post Author

Peter Daggett

Last Updated

March 25, 2026

Airsupra 2026 Availability, Prices, and Tips to Find

What Is Airsupra?

Airsupra is a first-of-its-kind rescue inhaler that combines albuterol (a short-acting beta2-agonist or SABA) with budesonide (an inhaled corticosteroid or ICS) in a single device. It is FDA-approved for as-needed treatment or prevention of bronchoconstriction and reduction of the risk of exacerbations in adults aged 18 and older with asthma. Manufactured by AstraZeneca, Airsupra is the first rescue inhaler to include an anti-inflammatory component, providing both immediate symptom relief and inflammation control in one puff.

How does Airsupra work?

Airsupra works through two complementary mechanisms. Albuterol sulfate is a short-acting beta2-adrenergic agonist that rapidly relaxes the smooth muscles lining the airways, causing them to widen and making it easier to breathe. Budesonide is an inhaled corticosteroid that reduces inflammation in the lungs with each rescue use. Together, they provide both immediate bronchodilation and anti-inflammatory protection — addressing the root cause of asthma (inflammation) every time you reach for your rescue inhaler.

What doses are available for Airsupra?

  • Metered-dose inhaler (MDI): 90 mcg albuterol / 80 mcg budesonide per actuation, 120 inhalations per canister (10.7g)

The standard dose is 2 inhalations (puffs) as needed, with a maximum of 12 inhalations (6 doses) per 24 hours.

How hard is it to find Airsupra in stock?

Airsupra scores a 58 out of 100 on our findability scale, meaning it can be moderately difficult to locate. While Airsupra is not listed on any FDA or ASHP drug shortage databases, it's a newer brand-name medication (FDA approved January 2023) with no generic alternative. Many pharmacies simply don't stock it due to its high cost and limited demand. You may need to call several pharmacies or use Medfinder to locate one that carries it.

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Who Can Prescribe Airsupra?

Airsupra can be prescribed by several types of healthcare providers, including:

  • Pulmonologists — lung and respiratory specialists
  • Allergists/Immunologists — specialists in allergies and immune-related conditions
  • Primary Care Physicians and Family Medicine doctors
  • Internal Medicine doctors
  • Emergency Medicine physicians

Telehealth consultations are also available for Airsupra prescriptions. If you're interested in switching from a traditional rescue inhaler to Airsupra, talk to your asthma care provider.

Is Airsupra a controlled substance?

No, Airsupra is not a controlled substance. It does not have a DEA schedule and can be prescribed and dispensed without the additional restrictions that apply to controlled medications. You can also order it through mail-order pharmacies and online platforms like AstraZeneca Direct.

Common Side Effects of Airsupra

  • Headache
  • Cough
  • Hoarseness (dysphonia)
  • Oral thrush (fungal infection in mouth/throat)

To reduce the risk of oral thrush, rinse your mouth with water and spit after each use. Contact your healthcare provider if side effects persist or become bothersome.

Alternative Medications to Airsupra

  • Albuterol (ProAir, Ventolin, Proventil): Traditional SABA rescue inhaler. Widely available as a generic and much less expensive, but does not contain an anti-inflammatory component.
  • Levalbuterol (Xopenex): A purified form of albuterol (R-isomer only). May cause fewer side effects like jitteriness and rapid heartbeat. Available as nebulizer solution and MDI.
  • Symbicort (Budesonide/Formoterol): Combination ICS/LABA maintenance inhaler that can also be used as maintenance and reliever therapy (MART). Contains budesonide like Airsupra but with a long-acting beta-agonist.
  • Breyna (Budesonide/Formoterol generic): Generic alternative to Symbicort. More affordable ICS/LABA combination for maintenance and reliever therapy.

Drug Interactions with Airsupra

  • Strong CYP3A4 inhibitors (ketoconazole, ritonavir, itraconazole, clarithromycin) — can increase budesonide levels in the body, raising the risk of side effects
  • Beta-blockers — may block the bronchodilating effect of albuterol and cause severe bronchospasm; generally avoid in asthma patients
  • MAO inhibitors and tricyclic antidepressants — can intensify cardiovascular effects of albuterol (increased heart rate and blood pressure)
  • Non-potassium-sparing diuretics — may worsen low potassium levels when used with albuterol
  • Digoxin — low potassium from beta-agonists may increase the risk of digoxin toxicity
  • QTc-prolonging drugs — combined risk of heart rhythm changes when used with albuterol

Always inform your doctor and pharmacist of all medications you take, including over-the-counter drugs and supplements.

Final Thoughts on Airsupra

Airsupra represents a significant advancement in asthma rescue treatment — it's the first inhaler to combine a fast-acting bronchodilator with an anti-inflammatory steroid in a single device. While the price tag can be steep without insurance ($479–$737), AstraZeneca's SUPRA Savings Card and AstraZeneca Direct program can significantly reduce out-of-pocket costs. The biggest challenge for patients is simply finding it in stock, as many pharmacies don't carry it yet. If your pharmacy doesn't have it, try using Medfinder to locate a pharmacy near you that does. Talk to your asthma doctor about whether Airsupra's dual-action approach is right for you.

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