Comprehensive medication guide to Afrezza including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$35–$75/month
Estimated Cash Pricing
$99–$2,320/month
Medfinder Findability Score
55/100
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Afrezza (insulin human) Inhalation Powder is the only FDA-approved ultra rapid-acting inhaled insulin for adults with Type 1 or Type 2 diabetes. Unlike traditional injectable insulins, Afrezza is breathed in through the mouth using a small, whistle-sized inhaler at the beginning of a meal. It uses MannKind's proprietary Technosphere technology to deliver insulin directly to the lungs, where it is rapidly absorbed into the bloodstream. Afrezza was FDA-approved in 2014 and is manufactured by MannKind Corporation.
Afrezza is used as a mealtime (prandial) insulin to control blood sugar spikes after eating. For Type 1 diabetes patients, it must be used in combination with a long-acting basal insulin. It is not a substitute for long-acting insulin and should not be used to treat diabetic ketoacidosis.
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12-unit cartridges (yellow)
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Serious side effects include acute bronchospasm (especially dangerous for patients with asthma or COPD), severe hypoglycemia, hypokalemia, and allergic reactions. Afrezza is contraindicated in patients with chronic lung disease. Patients who smoke or recently quit smoking should discuss risks with their doctor.
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Insulin Lispro (Humalog, Admelog, Lyumjev)
widely available, generic options exist
Insulin Aspart (NovoLog, Fiasp)
another common rapid-acting insulin; Fiasp has ultra-rapid onset
Insulin Glulisine (Apidra)
rapid-acting injectable insulin
Prefer Afrezza? We can find it.
Medications that may increase hypoglycemia risk:
moderateACE inhibitors, angiotensin receptor blockers (ARBs), fluoxetine (Prozac), MAO inhibitors, salicylates (aspirin), sulfonamide antibiotics, pramlintide, fibrates, pentoxifylline, and other antidiabetic drugs
Medications that may raise blood sugar:
moderatecorticosteroids, diuretics (thiazides), estrogens, oral contraceptives, glucagon, thyroid hormones, antipsychotics (e.g., olanzapine, clozapine), protease inhibitors, niacin, isoniazid, and sympathomimetics (e.g., albuterol, epinephrine)
Medications that may mask low blood sugar symptoms:
moderatebeta-blockers (e.g., metoprolol, propranolol), clonidine, guanethidine, and reserpine
Alcohol
moderatemay increase or unpredictably alter blood sugar levels
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