Comprehensive medication guide to Adenovirus Type 4 And Type 7 Vaccine, Live, Oral including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
No civilian insurance plan covers the Adenovirus Type 4 and Type 7 Vaccine because it is FDA-approved only for military populations. TRICARE provides it at no cost as a DoD-funded benefit. There is no formulary tier, prior authorization, or TRICARE copay associated with this vaccine.
Estimated Cash Pricing
The Adenovirus Type 4 and Type 7 Vaccine is not available through commercial channels and has no civilian cash price. It is procured and administered exclusively by the U.S. Department of Defense at an estimated $150 per person, at no cost to eligible military personnel.
Medfinder Findability Score
20/100
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The Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is an FDA-licensed live oral vaccine indicated for active immunization for the prevention of febrile acute respiratory disease (ARD) caused by adenovirus types 4 and 7. It was first approved by the FDA on March 16, 2011 (FDA license BL 125296), and is manufactured by Barr Labs, Inc. (now Teva Women's Health, Inc.).
This vaccine is approved exclusively for U.S. military populations aged 17 through 50. It is not available to civilians, military dependents, or veterans through any civilian healthcare channel. There is no brand name, no generic equivalent, and no civilian formulary listing for this vaccine. It is administered as two enteric-coated tablets (one Type 4 and one Type 7) taken orally at the same time. Tablets must be swallowed whole without chewing.
Adenoviruses types 4 and 7 have historically been the primary cause of febrile ARD outbreaks at U.S. military basic training installations, where crowded conditions, physical stress, and exposure to diverse regional populations create ideal transmission conditions. The vaccine's restoration in 2011 — after a 12-year hiatus — produced a 100-fold decline in adenovirus disease burden at military training sites.
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The Adenovirus Type 4 and Type 7 Vaccine works through a unique mechanism: the enteric-coated tablets pass intact through the acidic stomach and dissolve in the small intestine, releasing live adenovirus Types 4 and 7. The virus then replicates in the intestinal epithelium, establishing a controlled intestinal infection that triggers the immune system without causing respiratory illness.
This intestinal replication induces both systemic immunity (neutralizing IgG antibodies in the bloodstream) and mucosal immunity (secretory IgA antibodies at respiratory mucosal surfaces). The dual immune response provides protection against adenovirus Types 4 and 7 when the vaccinee is subsequently exposed to these viruses through respiratory contact with infected individuals.
As a consequence of the intestinal infection, the vaccine virus is shed in stool starting approximately day 7 and continuing for up to 28 days post-vaccination. This shedding is the basis for the required 28-day hand hygiene precautions and avoidance of close contact with pregnant women, children under 7, and immunocompromised individuals after vaccination.
32,000 TCID50 (4.5 log10 TCID50) per tablet — enteric-coated oral tablet
Single dose = 2 tablets taken simultaneously: one Adenovirus Type 4 tablet + one Adenovirus Type 7 tablet. Swallow whole — do not chew, crush, or break.
For civilians, the Adenovirus Type 4 and Type 7 Vaccine is impossible to find at any retail pharmacy — because it does not exist in civilian commerce. The vaccine is exclusively distributed through Department of Defense channels and administered only at military installations. No prescription can be written for it by a civilian provider, and no pharmacy carries it.
For eligible military personnel, findability is not an issue in the traditional sense. The vaccine is automatically administered to all eligible recruits during the in-processing vaccination period at basic training. The DoD's just-in-time delivery model ensures continuous supply at all nine basic training installations with no shortage reported as of 2026.
For other medications that are difficult to find at civilian pharmacies, medfinder can help. medfinder calls pharmacies near you to identify which ones have your prescription in stock, saving you the time and frustration of calling around yourself.
The Adenovirus Type 4 and Type 7 Vaccine can only be administered by authorized military healthcare personnel. It is not a scheduled (controlled) substance, but it is restricted to military-authorized settings. No civilian prescriber has the legal authority to prescribe or administer this vaccine regardless of their specialty or licensure.
Authorized military personnel who may administer this vaccine include:
Military Medical Officers (MOs) — commissioned physicians (MD/DO) within the Military Health System
Flight Surgeons — military physicians with aviation medicine specialization
Preventive Medicine Officers — military preventive medicine and epidemiology specialists
Military Nurse Practitioners and Physician Assistants — within the Military Health System under appropriate orders
Military immunization nurses (RNs) and medics (68W Army, HM Navy/USMC, 4N0X1 Air Force) — under medical officer oversight
Telehealth is not available for this vaccine. It must be physically administered and observed at an authorized military installation. Civilian telehealth providers have no access to this vaccine. The DoD Vaccine Clinical Call Center (1-866-210-6469, 24-hour) and MILVAX Agency (vaccines.mil, 1-877-438-8222) are the primary clinical resources for providers with questions.
No. The Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is not a controlled substance and is not scheduled under the Controlled Substances Act. It is classified as a biologic vaccine, regulated by the FDA's Center for Biologics Evaluation and Research (CBER) under FDA license BL 125296.
No special DEA registration, Schedule II prescription requirements, or controlled substance protocols apply to this vaccine. It is administered as part of standard military immunization programs. There are no refill restrictions in the controlled substance sense, as it is a single-dose vaccine administered once at military in-processing with no refills required.
The most common side effects (occurring in ≥5% of vaccine recipients in clinical trials) include:
Nasal congestion (15.3%)
Pharyngolaryngeal pain / sore throat (12.9%)
Cough (12.4%)
Headache
Arthralgia (joint pain)
Nausea, abdominal pain, diarrhea, vomiting
Low-grade fever (≥100.5°F in 1.4% of recipients)
Serious side effects (rare):
Anaphylaxis (severe allergic reaction) — seek emergency care immediately
Guillain-Barré syndrome (progressive muscle weakness) — seek emergency evaluation
Blood in stool (hematochezia) — report to sick call immediately
Pneumonia — report to medical provider
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Annual Influenza Vaccine
FDA-approved for civilian use at all pharmacies. Prevents seasonal influenza (flu), which has similar respiratory symptoms to adenovirus ARD. Available as injection or nasal spray; updated annually. No direct adenovirus protection.
RSV Vaccines (Abrysvo, Arexvy)
FDA-approved RSV vaccines for adults 60+ and pregnant women. Prevents RSV lower respiratory tract disease. Available at civilian pharmacies and providers. No adenovirus protection.
Pneumococcal Vaccines (Prevnar 20, Pneumovax 23)
Protect against Streptococcus pneumoniae, a leading cause of bacterial pneumonia that can complicate viral respiratory illness including adenovirus. Available at civilian pharmacies for eligible adults.
COVID-19 Vaccines (Comirnaty, Spikevax)
Updated mRNA COVID-19 vaccines protect against SARS-CoV-2, another respiratory pathogen. Broadly available at civilian pharmacies. No adenovirus protection.
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Certolizumab pegol (Cimzia)
majorTNF inhibitor biologic. Do not give live vaccines concurrently with certolizumab. Contraindicated.
Ibrutinib (Imbruvica)
majorBTK inhibitor. Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of infection. Live vaccines should be avoided for at least 3 months after cessation of immunosuppressive therapy. Contraindicated.
Cyclosporine
majorImmunosuppressant. Avoid live vaccines in immunocompromised patients due to risk of clinical infection. Avoid live vaccines for at least 3 months after cessation unless benefit outweighs risk. Contraindicated.
High-dose corticosteroids
majorImmunosuppressive doses of systemic corticosteroids (≥20 mg/day prednisone equivalent for ≥2 weeks). Avoid live vaccines for at least 1 month when initiating or after stopping high-dose therapy.
Immune globulins
moderateVaccinia immune globulin (IV) and Rho(D) immune globulin may interfere with immune response to live vaccines. Defer live vaccines for 3 months after immune globulin administration.
Abatacept (Orencia)
moderateCTLA-4 immunoglobulin. Immunosuppressives may diminish therapeutic effects of vaccines. Live vaccines should be avoided for at least 3 months after cessation of therapy.
Fingolimod (Gilenya)
moderateMS medication. Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of infection. Avoid live vaccines.
The Adenovirus Type 4 and Type 7 Vaccine, Live, Oral is one of the most unique vaccines in the U.S. healthcare landscape—a military-only biologic that has no civilian equivalent, no retail availability, and no civilian prescribing pathway. Its 50-year history of use (1971–present, excluding the 1999–2011 hiatus) and its dramatic impact on military recruit health make it one of the most operationally important vaccines in the DoD's arsenal.
For military recruits: you will receive this vaccine at basic training as part of your entry immunization schedule. Know what to expect (mild respiratory and GI symptoms are common in the first week), follow the 28-day hand hygiene and contact precautions, and avoid pregnancy for 6 weeks post-vaccination. The vaccine protects you from one of the historically most disruptive diseases in military training environments.
For civilians, veterans, and transitioning service members who need help finding other medications at civilian pharmacies: medfinder can locate which pharmacies near you have your prescription in stock, saving you hours of frustrating phone calls. medfinder covers all medications available at civilian pharmacies.
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