Veozah (Fezolinetant) is a prescription medication used to treat moderate to severe hot flashes and night sweats caused by menopause. It is the first neurokinin 3 (NK3) receptor antagonist approved by the FDA for vasomotor symptoms and does not contain hormones.

If you or someone you know is dealing with menopause-related hot flashes, this guide covers everything you need to know about Veozah in 2026 — what it is, how it works, who it's for, and what it costs.

What Is Veozah?

Veozah is the brand name for Fezolinetant, a neurokinin 3 (NK3) receptor antagonist. Here are the basics:

• Brand name: Veozah (also marketed as Veoza outside the US)
• Generic name: Fezolinetant
• Drug class: Neurokinin 3 (NK3) receptor antagonist
• Manufacturer: Astellas Pharma
• FDA approval: Approved for the treatment of moderate to severe vasomotor symptoms due to menopause
• Controlled substance: No — Veozah is not a controlled substance
• Generic available: No — Veozah is brand-only and under patent protection as of 2026

Veozah represents a new class of medication for menopause. Unlike hormone replacement therapy (HRT) or the SSRI-based Brisdelle, Veozah works by targeting a specific receptor in the brain's temperature control center. For a detailed explanation, see our guide on how Veozah works.

What Is Veozah Used For?

Veozah is FDA-approved for one indication:

• Treatment of moderate to severe vasomotor symptoms (VMS) due to menopause — this includes hot flashes and night sweats

Vasomotor symptoms are the most common reason women seek treatment during menopause. Hot flashes can range from mild warmth to intense heat with sweating, flushing, and rapid heartbeat. Night sweats can severely disrupt sleep. Veozah is specifically designed for women experiencing moderate to severe episodes — meaning hot flashes that are frequent, intense, or significantly impact daily life and sleep.

Veozah is not approved for mild hot flashes, weight loss, mood changes, or any other menopause symptom. It is also being studied for polycystic ovary syndrome (PCOS) in early-stage clinical trials, but this is not an approved use.

How Is Veozah Taken?

Veozah comes in one formulation:

• 45 mg oral tablet — a round, light red, film-coated tablet debossed with the Astellas logo and "645"

Dosing Instructions

• Take one 45 mg tablet once daily by mouth
• Take it with or without food
• Take it at about the same time each day
• Swallow the tablet whole with liquid — do not cut, crush, or chew
• If you miss a dose, take it as soon as possible on the same day, with at least 12 hours before your next dose
• Store at room temperature (68°F–77°F)

There is no dose titration with Veozah — you start at 45 mg and stay at 45 mg. This simplicity is one of the advantages of the medication.

Who Should Not Take Veozah?

Veozah is not appropriate for everyone. The following are contraindications — situations where Veozah should not be used:

• Cirrhosis — any form of liver cirrhosis
• Severe kidney impairment or end-stage renal disease
• Known liver disease or elevated baseline liver enzymes (aminotransferases 2 times or more above the upper limit of normal, or bilirubin 2 times or more above normal)
• Concomitant use with CYP1A2 inhibitors — medications like Fluvoxamine, Ciprofloxacin, Enoxacin, Methoxsalen, Mexiletine, and Vemurafenib. See our drug interactions guide for the complete list.

Additionally, there is no data on Veozah use during pregnancy or breastfeeding.

The Boxed Warning

Veozah carries a boxed warning for hepatotoxicity (liver injury). This is the FDA's most serious type of warning. Liver blood tests (ALT, AST, bilirubin) are required before starting treatment and at months 1, 2, 3, 6, and 9. Learn more about what to watch for in our side effects guide.

How Much Does Veozah Cost?

Veozah is a brand-name medication with no generic alternative, so costs can be significant:

• Cash price: $550–$765 per month (30 tablets of 45 mg)
• With insurance: Varies widely. Many commercial plans cover Veozah but often require prior authorization and may place it on a higher tier (Tier 3–4). Your copay could range from $30 to over $200 depending on your plan.
• Medicare Part D: Some plans cover Veozah. The 2025 Part D out-of-pocket cap of $2,000 per year helps limit total exposure.

Ways to Save

• Veozah Savings Card: Astellas offers a savings card for commercially insured patients — as little as $0 for the first month and $30 per refill, with up to $4,000 in annual copay assistance. Enroll at veozah.com/savings.
• Patient assistance programs: Uninsured or underinsured patients can explore Veozah Support Solutions (veozahsupportsolutions.com), NeedyMeds, RxAssist, and RxHope.
• Discount cards: SingleCare, GoodRx, BuzzRx, and other discount programs may offer reduced pricing at certain pharmacies.

For a complete breakdown of every savings option, read our guide to saving money on Veozah.

How Does Veozah Compare to Alternatives?

Veozah is one of several options for treating menopause-related hot flashes. Here's how it compares:

• Lynkuet (Elinzanetant): A newer dual NK1/NK3 receptor antagonist approved in October 2025. Also nonhormonal. May additionally help with sleep due to its NK1 activity.
• Brisdelle (Paroxetine 7.5 mg): The only other FDA-approved nonhormonal option for VMS. An SSRI that does not require liver monitoring but may cause drowsiness and other SSRI-related side effects.
• Hormone replacement therapy (HRT): Estrogen-based therapies remain the most effective treatment for hot flashes but are not appropriate for women with a history of breast cancer or blood clots.
• Off-label options: Effexor XR (Venlafaxine), Neurontin (Gabapentin), and Catapres (Clonidine) are sometimes used off-label when other treatments aren't suitable.

For a deeper comparison, see our guide to Veozah alternatives.

Final Thoughts

Veozah is a meaningful option for women dealing with moderate to severe hot flashes from menopause — especially those who can't or prefer not to use hormones. It's taken once daily, doesn't require dose adjustment, and works through a targeted, nonhormonal mechanism.

The trade-offs are its cost ($550–$765 per month without savings programs), the boxed warning for liver injury, and the required liver monitoring schedule. For many women, the relief from debilitating hot flashes is well worth these considerations — particularly with savings programs that can bring the monthly cost down to $30 or less.

If you're considering Veozah, talk to your doctor about whether it's right for you. Then use Medfinder to find a pharmacy near you that has it in stock.