What Is Skyrizi (Risankizumab)? Uses, Dosage, and What You Need to Know in 2026

Skyrizi (risankizumab-rzaa) is a prescription biologic medication made by AbbVie. It belongs to a class of drugs called interleukin-23 (IL-23) inhibitors — biologics that work by blocking a specific protein in the immune system that triggers inflammation. Skyrizi was first approved by the FDA in April 2019 and has since received approval for four separate conditions.

Here's everything patients need to know about Skyrizi in 2026 — including what it treats, how it's given, dosing schedules, storage, and what makes it different from other biologics.

What Does Skyrizi Treat? (FDA-Approved Indications)

Skyrizi is FDA-approved for four conditions in adults:

Moderate to severe plaque psoriasis — Approved April 2019. For adults who are candidates for systemic therapy or phototherapy. Skyrizi is one of the most effective treatments for psoriasis, with clinical trials showing 90%+ skin clearance in a majority of patients.

Active psoriatic arthritis (PsA) — Approved January 2022. Treats both the skin and joint components of psoriatic arthritis.

Moderately to severely active Crohn's disease — Approved June 2022. Skyrizi was the first IL-23 specific inhibitor approved for Crohn's disease.

Moderately to severely active ulcerative colitis (UC) — Approved June 2024. The most recent FDA approval for Skyrizi.

Dosing: How Is Skyrizi Given?

The dosing schedule for Skyrizi depends on which condition is being treated:

Plaque Psoriasis and Psoriatic Arthritis

150 mg injected subcutaneously (under the skin) at weeks 0 and 4 ("starter doses"), then 150 mg every 12 weeks (once a quarter). This means just 4 doses per year after the two starter doses — one of the most convenient dosing schedules among biologic therapies for psoriasis.

Crohn's Disease

Induction (given in a clinic): 600 mg intravenously (IV) at weeks 0, 4, and 8. Starting at week 12: Maintenance: 180 mg or 360 mg subcutaneously every 8 weeks (self-administered using an on-body injector). Note: In April 2026, AbbVie submitted an FDA application for subcutaneous induction — if approved, IV induction would become optional.

Ulcerative Colitis

Induction: 1,200 mg IV at weeks 0, 4, and 8 (given in a clinic). Starting at week 12: Maintenance: 180 mg or 360 mg subcutaneously every 8 weeks (self-administered).

Dosage Forms and How to Inject Skyrizi

Skyrizi is available in the following formulations:

150 mg/mL prefilled autoinjector pen — for psoriasis and PsA (self-administered)

75 mg/0.83 mL prefilled syringe (two used per dose) — an alternative for psoriasis/PsA

600 mg/10 mL single-dose vial — for IV infusion (Crohn's and UC induction, given by healthcare provider)

180 mg/1.2 mL and 360 mg/2.4 mL prefilled cartridges with on-body injector — for Crohn's and UC maintenance (self-administered)

Subcutaneous injections are given in the abdomen, thigh, or (if administered by a caregiver) the upper outer arm. Rotate injection sites. Never inject into skin that is tender, bruised, red, or affected by psoriasis.

How to Store Skyrizi

Store Skyrizi in the refrigerator between 36°F and 46°F (2°C to 8°C). Keep it in its original carton to protect it from light. Do not freeze and do not shake. Before injection, allow the pen or syringe to reach room temperature without removing it from the carton: 30–90 minutes for the pen, 15–30 minutes for the syringe.

Is Skyrizi a Controlled Substance?

No. Skyrizi is not a controlled substance. It has no DEA scheduling restrictions. There are no limitations on prescription refills based on drug scheduling. However, your insurer's prior authorization requirements and step therapy policies do create their own access restrictions.

Is There a Generic Version of Skyrizi?

No. There is no FDA-approved generic or biosimilar version of Skyrizi as of 2026. AbbVie maintains exclusivity, and biosimilar competitors are not expected until after 2028. Until then, Skyrizi is only available as the AbbVie brand product.

To understand how Skyrizi works at the molecular level, see How Does Skyrizi Work? Mechanism of Action Explained. Once you have a prescription, use medfinder to find a specialty pharmacy that can fill it.