Orapred at a Glance

Orapred is the brand name for Prednisolone Sodium Phosphate, a synthetic corticosteroid (glucocorticoid) used to treat a wide range of inflammatory, allergic, and autoimmune conditions. It's manufactured by Concordia Pharmaceuticals and is especially popular in pediatric medicine because it comes in a liquid oral solution that's easier for children to swallow than tablets.

If you or your child has been prescribed Orapred, this guide covers everything you need to know — from what it treats and how to take it, to dosage information and safety precautions.

What Does Orapred Treat?

Orapred is FDA-approved for a broad range of conditions. It works by suppressing the immune system and reducing inflammation throughout the body. Common uses include:

Asthma Exacerbations

One of the most frequent reasons Orapred is prescribed, particularly in children. A short 3–5 day "burst" of Orapred can quickly reduce airway inflammation during an asthma flare, helping the patient breathe normally again.

Allergic Conditions

Severe allergic reactions, allergic rhinitis, and anaphylaxis follow-up treatment may all involve Orapred. It calms the inflammatory cascade triggered by the allergic response.

Croup in Children

Orapred is commonly prescribed for croup — the barking cough caused by inflammation of the upper airway. A single dose or short course can significantly reduce swelling and improve symptoms.

Autoimmune Disorders

Conditions like lupus, multiple sclerosis flares, and inflammatory arthritis may be treated with Orapred to suppress the overactive immune response attacking the body's own tissues.

Nephrotic Syndrome

In children, Orapred is a first-line treatment for nephrotic syndrome, a kidney condition causing protein loss in the urine and significant swelling.

Other Approved Uses

• Hematologic disorders like idiopathic thrombocytopenic purpura (ITP)
• Inflammatory bowel disease flares
• Adrenal insufficiency (as replacement therapy)
• Severe dermatitis and inflammatory skin conditions

Off-Label Uses

Doctors sometimes prescribe Orapred for conditions not listed on the official label, including:

• Acute sinusitis
• Bell's palsy
• Gout flares
• COPD exacerbations
• Severe poison ivy or contact dermatitis

For a deeper look at how Orapred works at the cellular level, see our mechanism of action guide.

Orapred Dosage Forms

Orapred is available in several formulations:

• Orapred Oral Solution — 15 mg/5 mL. This grape-flavored liquid is the most commonly prescribed form, especially for children. It comes with a calibrated measuring device.
• Orapred ODT (Orally Disintegrating Tablets) — Available in 10 mg, 15 mg, and 30 mg. These tablets dissolve on the tongue and can be taken with or without water. A good option for older children or adults who prefer a tablet.

Generic versions are also available:

• Generic Prednisolone Sodium Phosphate solution 15 mg/5 mL
• Pediapred oral solution 5 mg/5 mL
• Prelone syrup 15 mg/5 mL

Typical Dosing

Important: Always follow your doctor's specific instructions. The information below is general guidance only.

Adults

The typical adult dose ranges from 5 to 60 mg per day, depending on the condition being treated. Most prescriptions are for short courses (3–10 days) at moderate doses.

Children

For asthma exacerbations and croup, the standard pediatric dose is 1–2 mg/kg/day, with a maximum of 60 mg/day. This is usually given as a single daily dose or split into two doses, for 3–5 days.

Your doctor will calculate the exact dose based on your child's weight. Use the measuring device provided with the oral solution — do not use a household spoon, as this can lead to inaccurate dosing.

How to Take Orapred

• Take with food — This reduces stomach upset and nausea.
• Take in the morning — Mimics your body's natural cortisol rhythm and helps prevent insomnia.
• Use the measuring device — For the oral solution, always use the calibrated syringe or cup provided.
• For ODT tablets — Place on the tongue and let it dissolve. You can swallow with or without water.
• Complete the full course — Even if you feel better, finish the prescribed course unless your doctor says otherwise.
• Don't stop abruptly after prolonged use — If you've taken Orapred for more than 1–2 weeks, your doctor will taper the dose gradually to prevent adrenal insufficiency.

What You Should Tell Your Doctor Before Taking Orapred

Make sure your doctor knows about:

• Current infections — Orapred suppresses the immune system. Active infections, especially fungal infections, may be a contraindication.
• Diabetes — Orapred raises blood sugar and may require adjustments to diabetes medications.
• Other medications — Several drugs interact with Orapred, including NSAIDs, blood thinners, seizure medications, and certain antifungals. See our full drug interactions guide.
• Pregnancy or breastfeeding — Orapred is Pregnancy Category C. Use only if the benefit outweighs the risk.
• Recent vaccinations — Live vaccines should not be given during immunosuppressive doses of Orapred.
• History of GI problems — Ulcers, gastritis, or GI bleeding increase the risk of stomach complications.

Contraindications

Orapred should not be used if you have:

• Systemic fungal infections
• Known hypersensitivity to Prednisolone or any component of the formulation
• Plans to receive live or live-attenuated vaccines while on immunosuppressive doses

Side Effects Overview

Like all corticosteroids, Orapred has side effects. Common ones include increased appetite, mood changes, insomnia, and stomach upset. Serious side effects — more common with prolonged use — include adrenal suppression, osteoporosis, and increased infection risk.

For a complete breakdown, read our detailed Orapred side effects guide.

Orapred vs. Other Corticosteroids

How does Orapred compare to similar medications?

• Orapred vs. Prednisone — Prednisone is converted to Prednisolone in the liver. Orapred (Prednisolone) is the active form, which may be preferable for patients with liver problems. Orapred also comes in liquid form, making it better for children.
• Orapred vs. Dexamethasone — Dexamethasone is more potent and longer-acting. A single dose of Dexamethasone is sometimes used as an alternative to a multi-day course of Orapred, especially for croup.
• Orapred vs. Methylprednisolone (Medrol) — Similar potency, but Methylprednisolone may cause less sodium retention. Available as tablets and injections.
• Orapred vs. Hydrocortisone — Hydrocortisone is lower potency and used primarily for adrenal replacement therapy and milder conditions.

If you can't find Orapred, our guide on alternatives to Orapred can help you discuss options with your doctor.

Availability and Cost in 2026

Orapred has faced intermittent shortages due to limited manufacturers of the liquid formulation. If you're having trouble finding it, use MedFinder to check pharmacy stock near you.

Cost-wise, brand-name Orapred oral solution runs $50–$200+ without insurance, while the generic is typically $15–$50. Orapred ODT can be $200–$500+ without insurance. Generic Prednisolone is covered by most insurance plans as a Tier 1 preferred generic.

For savings strategies, check out our guide on Orapred coupons, discounts, and patient assistance programs.

The Bottom Line

Orapred is a trusted, effective corticosteroid used to treat inflammation, allergic reactions, asthma, and autoimmune conditions. Its liquid formulation makes it particularly valuable for pediatric patients. While side effects are possible, short courses are generally well-tolerated. Work closely with your doctor on dosing, be aware of drug interactions, and don't stop the medication abruptly after prolonged use.

Need Orapred? Find it in stock near you with MedFinder.