What Is Genvoya? Uses, Dosage, and What You Need to Know in 2026

Genvoya is a once-daily prescription tablet used to treat HIV-1 (human immunodeficiency virus type 1). It combines four antiretroviral medications into a single pill, making it a complete HIV treatment regimen on its own — no additional HIV medications required. Here's everything you need to know about Genvoya in 2026.

What Is Genvoya?

Genvoya (pronounced jen-VOY-uh) is a brand-name medication manufactured by Gilead Sciences. It is a fixed-dose combination tablet containing:

Elvitegravir (EVG) 150 mg: An integrase strand transfer inhibitor (INSTI) that prevents HIV from inserting its genetic material into human cells

Cobicistat (COBI) 150 mg: A pharmacokinetic booster that increases elvitegravir blood levels by slowing its breakdown in the liver

Emtricitabine (FTC) 200 mg: A nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV replication

Tenofovir alafenamide (TAF) 10 mg: Another NRTI that blocks HIV replication; a newer, lower-dose form of tenofovir with less impact on kidneys and bones than the older TDF formulation

Genvoya was FDA-approved in November 2015. The tablets are green, capsule-shaped, and film-coated, debossed with "GSI" on one side and "510" on the other.

What Is Genvoya Used For?

Genvoya is FDA-approved for two groups of HIV patients:

Treatment-naïve patients: Adults and adolescents weighing at least 25 kg (55 lbs) with no prior antiretroviral treatment history, who have no known resistance mutations to Genvoya's components.

Virologically suppressed patients switching regimens: Adults and adolescents currently on a stable HIV regimen for at least 6 months, with HIV-1 RNA below 50 copies/mL, no history of treatment failure, and no known resistance to Genvoya's components.

Genvoya does not cure HIV or AIDS. It suppresses the virus to undetectable levels, which protects the immune system and dramatically reduces the risk of AIDS-related complications. Patients on effective HIV therapy like Genvoya can live long, healthy lives.

How Effective Is Genvoya?

Genvoya has strong clinical trial data. In the pivotal Phase 3 trials, approximately 90% of treatment-naïve patients achieved viral suppression (HIV-1 RNA <50 copies/mL) after 48 weeks. In switching studies, 97% of virologically suppressed patients who switched to Genvoya maintained suppression at 48 weeks. These are excellent outcomes that make Genvoya one of the most effective HIV regimens available.

How to Take Genvoya

Dose: One tablet taken orally once daily

With food: Genvoya MUST be taken with food. Food is not optional — it significantly improves absorption and reduces nausea.

Consistency: Take at the same time every day. Do not skip doses.

Missed dose: If you miss a dose, take it as soon as you remember — unless it's almost time for your next dose, in which case skip it and take the next dose on schedule. Never double up.

Antacids: Take Genvoya at least 2 hours before or 2 hours after antacids containing aluminum, calcium, or magnesium.

Storage

Store Genvoya below 86°F (30°C). Keep it in the original container with the cap tightly closed. Do not remove the desiccant packet inside the container — it protects the tablets from moisture.

Who Should Not Take Genvoya?

Genvoya is not appropriate for everyone. It is NOT recommended for patients who:

Are pregnant (substantially lower exposures of cobicistat and elvitegravir occur during pregnancy)

Have severe renal impairment (CrCl <30 mL/min) and are not on hemodialysis

Have severe hepatic impairment (Child-Pugh Class C)

Are taking contraindicated drugs (St. John's wort, rifampin, lovastatin, simvastatin, triazolam, oral midazolam, and others)

See our full guide on Genvoya drug interactions for a complete list of medications to avoid.

Is Genvoya Available as a Generic?

No. As of 2026, there is no FDA-approved generic version of Genvoya. It is only available as the brand-name product from Gilead Sciences.

Finding Genvoya at a Pharmacy Near You

Because Genvoya is a specialty medication, it isn't stocked at every retail pharmacy. If you need help finding a pharmacy that has it, medfinder contacts pharmacies near you to find which ones can fill your Genvoya prescription and texts you the results.