Dymista Is a Prescription Nasal Spray That Combines an Antihistamine and a Corticosteroid to Treat Seasonal Allergies

Dymista (azelastine hydrochloride/fluticasone propionate) is a combination nasal spray used to relieve the symptoms of seasonal allergic rhinitis — the sneezing, congestion, runny nose, and itching that come with allergy season. It's one of the few nasal sprays that combines two types of allergy-fighting ingredients in a single product.

Whether your doctor just prescribed it or you're researching your options, here's everything you need to know about Dymista in 2026.

What Is Dymista?

Dymista is a prescription metered-dose nasal spray containing two active ingredients:

• Azelastine hydrochloride (137 mcg per spray) — An antihistamine that blocks histamine H1-receptors, providing fast-acting relief from sneezing, itching, and runny nose.
• Fluticasone propionate (50 mcg per spray) — A synthetic corticosteroid that reduces nasal inflammation, swelling, and congestion over time.

The combination is what makes Dymista unique: you get the quick relief of an antihistamine plus the sustained anti-inflammatory power of a steroid in one spray. For more on how this works, see our article on how Dymista works.

Key Facts

• Brand name: Dymista
• Generic name: Azelastine hydrochloride and fluticasone propionate
• Drug class: Combination antihistamine/intranasal corticosteroid
• Manufacturer: Viatris Specialty LLC (originally Meda Pharmaceuticals)
• FDA approval: Approved for seasonal allergic rhinitis
• Controlled substance: No — Dymista is not a controlled substance
• Generic available: Yes

What Is Dymista Used For?

Dymista is FDA-approved for the relief of symptoms of seasonal allergic rhinitis in adults and children aged 6 and older. These symptoms include:

• Nasal congestion (stuffy nose)
• Runny nose (rhinorrhea)
• Sneezing
• Nasal itching

While its FDA-approved indication is seasonal allergies, doctors sometimes prescribe Dymista off-label for:

• Perennial allergic rhinitis — Year-round allergies triggered by dust mites, pet dander, or mold
• Non-allergic rhinitis (vasomotor rhinitis) — Chronic nasal symptoms without an allergic cause
• Nasal polyp symptom management — Helping manage congestion associated with nasal polyps

How Is Dymista Taken?

The standard dosage is 1 spray in each nostril twice daily. This delivers a total daily dose of 548 mcg of azelastine and 200 mcg of fluticasone.

How to Use Dymista Properly

1. Prime the pump before first use by spraying 6 times away from your face until a fine mist appears. Re-prime if the spray hasn't been used for 14 or more days.
2. Gently blow your nose to clear your nasal passages.
3. Insert the nozzle into one nostril. Tilt your head slightly forward.
4. Close the other nostril with your finger.
5. Spray once while breathing in gently through your nose.
6. Repeat for the other nostril.
7. Don't blow your nose immediately after spraying.
8. Clean the nozzle tip regularly to prevent buildup.

Each bottle contains approximately 120 sprays — enough for a 30-day supply at the standard dose.

Who Should Not Take Dymista?

Dymista is not appropriate for everyone. You should not use it if you have:

• A known allergy to azelastine, fluticasone, or any ingredient in the formulation
• Recent nasal surgery or nasal trauma (wait until fully healed)
• Untreated localized nasal infections

Use with caution if you:

• Are pregnant (Category C) or breastfeeding
• Have severe liver impairment
• Have a history of glaucoma or cataracts
• Are taking strong CYP3A4 inhibitors like ritonavir or ketoconazole

Children under age 6 should not use Dymista. For pediatric patients 6 and older, growth should be monitored during treatment.

For a full list of potential interactions, see our guide on Dymista drug interactions. For side effect details, read Dymista side effects: what to expect.

How Much Does Dymista Cost?

Dymista's cost varies significantly depending on whether you get the brand name or generic, and what type of savings you use:

• Brand-name Dymista: $200–$300 per bottle (approximately 30-day supply) without insurance
• Generic azelastine/fluticasone: $50–$90 with a discount coupon (GoodRx prices as low as ~$54); $150–$250 retail without coupons
• With commercial insurance: Varies by plan and tier. Dymista is often on Tier 3 or Tier 4. Prior authorization or step therapy (trying OTC options first) may be required.
• Dymista Copay Relief Card: Eligible commercially insured patients may pay as little as $29 per prescription (maximum benefit of $150 per 30-day prescription; not valid for government insurance)
• Patient assistance: The Viatris Patient Assistance Program provides free medication to qualifying uninsured or underinsured patients

For a complete breakdown of savings options, see our guide to saving money on Dymista.

Final Thoughts

Dymista stands out as one of the most effective nasal sprays for seasonal allergies because it combines two proven approaches — antihistamine relief and corticosteroid inflammation control — in a single product. For people who haven't gotten enough relief from OTC sprays like Flonase or Astepro alone, Dymista can be a significant upgrade.

Talk to your doctor about whether Dymista is right for you, and use Medfinder to find a pharmacy with Dymista in stock near you.