What Is Dupixent? Uses, Dosage, and What You Need to Know in 2026

Dupixent (dupilumab) is a prescription biologic medication manufactured by Sanofi and Regeneron Pharmaceuticals. Since its first FDA approval in March 2017 for atopic dermatitis, it has expanded to become one of the broadest-approved biologics in medicine — now with 9 FDA-approved indications affecting the skin, lungs, sinuses, esophagus, and immune system.

Here's what you need to know about Dupixent in 2026 — from what it treats to how it's given to how much it costs.

What Conditions Does Dupixent Treat?

As of 2026, Dupixent is FDA-approved for nine distinct conditions:

Atopic Dermatitis (Eczema) — for adults and children 6 months and older with moderate-to-severe AD not adequately controlled by topical therapies

Asthma — add-on maintenance for adults and children 6 years and older with moderate-to-severe asthma with an eosinophilic phenotype or oral corticosteroid dependence

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) — add-on maintenance for patients 12 years and older with inadequately controlled CRSwNP

Eosinophilic Esophagitis (EoE) — for adults and children 1 year and older weighing at least 15 kg

Prurigo Nodularis (PN) — for adults with nodular, intensely itchy skin lesions

Chronic Obstructive Pulmonary Disease (COPD) — add-on maintenance for adults with inadequately controlled COPD and an eosinophilic phenotype

Chronic Spontaneous Urticaria (CSU) — for patients 6 months and older with antihistamine-refractory chronic hives (most recently expanded to children aged 2–11 in April 2026)

Bullous Pemphigoid (BP) — for adults with this autoimmune blistering skin condition

Allergic Fungal Rhinosinusitis (AFRS) — for adults and children 6 years and older with a history of sinus surgery

How Is Dupixent Given?

Dupixent is given as a subcutaneous injection — under the skin of the abdomen, thigh, or upper arm (with caregiver assistance). It comes as:

Prefilled pen: For adults and children 2 years and older — easier to self-administer

Prefilled syringe: For adults and children 6 months and older — requires more manual technique

Available strengths: 200 mg/1.14 mL and 300 mg/2 mL.

How Often Is Dupixent Injected?

Dosing frequency depends on your condition and, for children, your weight. For adult atopic dermatitis patients: a 600 mg loading dose (two 300 mg injections), followed by 300 mg every 2 weeks. For asthma: a 400 mg loading dose (two 200 mg injections), followed by 200 mg every 2 weeks or 300 mg every 4 weeks depending on your phenotype. For COPD: 300 mg every 2 weeks with no loading dose. Your prescriber will tell you your specific schedule.

How Do I Store Dupixent?

Store Dupixent in the refrigerator at 36°F–46°F (2°C–8°C) in the original carton to protect it from light. Do not freeze or shake it. If you need to travel or store it at room temperature, you can keep it at up to 77°F (25°C) for up to 14 days — but you must use it or discard it after that. Allow it to warm to room temperature for 30–45 minutes before injecting to reduce injection discomfort.

Is Dupixent a Steroid? Is It an Immunosuppressant?

No on both counts. Dupixent is a monoclonal antibody — a precisely engineered biologic that blocks two specific inflammatory proteins (IL-4 and IL-13). It is not a steroid and does not cause the side effects associated with long-term steroid use (weight gain, osteoporosis, adrenal suppression). It is also not an immunosuppressant — it does not broadly suppress your immune system, so you are not at increased risk of the types of serious infections associated with traditional immunosuppressants.

When Will Dupixent Start Working?

Most patients begin to notice improvement within 2–4 weeks of starting Dupixent. More significant improvement — such as substantial skin clearing in eczema patients — is typically seen at 12–16 weeks. Dupixent is a maintenance medication, meaning it's designed for long-term use. Stopping treatment often leads to a return of symptoms.

Is There a Generic Version of Dupixent?

There is no traditional generic for Dupixent. Because it's a biologic (made from living cells), the equivalent would be a biosimilar. One biosimilar to dupilumab has been approved by the FDA but had not launched commercially as of early 2026.

How Can I Access Dupixent?

Dupixent is only available through specialty pharmacies. After getting a prescription from a specialist, your insurance plan must approve coverage through prior authorization, and the prescription is then fulfilled by a specialty pharmacy — usually by home delivery. For cost savings options, see our guide to saving money on Dupixent. And if you're searching for which specialty pharmacy near you can fill your prescription, medfinder can help.