What Is Dicyclomine? Uses, Dosage, and What You Need to Know in 2026

If your doctor has prescribed dicyclomine for irritable bowel syndrome, you may have questions about what it is, how it works, and what to expect. This guide covers the essentials — from FDA approval to dosing to what makes this medication different from other IBS treatments.

What Is Dicyclomine?

Dicyclomine (also known as dicycloverine) is a prescription medication classified as an anticholinergic antispasmodic. It was first approved by the FDA in 1950, making it one of the longest-standing prescription treatments for functional gastrointestinal disorders. It is the active ingredient in the brand-name drug Bentyl — though Bentyl's oral forms have since been discontinued, and only the generic version is available for oral use.

In 2023, dicyclomine was the 192nd most commonly prescribed medication in the United States, with more than 2 million prescriptions dispensed. It is a widely used, well-studied generic medication.

What Is Dicyclomine Used For?

Dicyclomine's only FDA-approved indication is the treatment of functional bowel/irritable bowel syndrome (IBS). Specifically, it targets the abdominal cramping and spasms that are hallmark symptoms of IBS — particularly the pain that comes in waves and is related to gut motility.

Off-label, some providers have used it for other conditions involving smooth muscle spasm, including diverticulitis and functional dyspepsia. However, its evidence base is strongest for IBS.

What Dosage Forms Is Dicyclomine Available In?

Dicyclomine is available in the following forms:

10 mg oral capsule — taken by mouth

20 mg oral tablet — most commonly prescribed and most widely stocked form

40 mg oral tablet — for patients at the full maintenance dose

10 mg/5 mL oral syrup — for patients who have difficulty swallowing tablets or capsules

10 mg/mL intramuscular injection — for short-term inpatient use when oral administration is not possible (Bentyl brand + generic)

How Do You Take Dicyclomine?

The standard dosing for dicyclomine is:

Starting dose: 20 mg taken four times daily (80 mg/day total)

Maintenance dose: Up to 40 mg four times daily (160 mg/day total) after 1 week, if tolerated and needed

Duration: Discontinue if no benefit after 2 weeks or if side effects prevent using at least 80 mg/day

Dicyclomine can be taken with or without food. If you miss a dose, take it when you remember — unless it's almost time for your next scheduled dose. Never double up.

Who Should Not Take Dicyclomine?

Dicyclomine is contraindicated (should not be used) in the following conditions:

Infants under 6 months old — risk of life-threatening respiratory effects

Breastfeeding women — dicyclomine passes into breast milk

Glaucoma — the drug can increase intraocular pressure

Obstructive uropathy (urinary tract blockage)

Myasthenia gravis — dicyclomine can worsen muscle weakness

Severe ulcerative colitis — risk of toxic megacolon

Reflux esophagitis — can worsen the condition

Is Dicyclomine a Controlled Substance?

No. Dicyclomine is not a DEA-scheduled controlled substance. Cases of abuse have been very rarely reported, but it is not considered a drug with significant abuse potential. It does not require special prescriber registration and can be prescribed via telehealth.

How Much Does Dicyclomine Cost?

Dicyclomine is an inexpensive generic medication. Without insurance, a standard fill of 20 mg tablets typically costs $15–$22 at retail pharmacy prices. Using a GoodRx coupon, prices drop to as low as $3.27. With insurance on a Tier 1 plan, copays are typically $0–$10.

What If I Can't Find Dicyclomine at My Pharmacy?

Dicyclomine is not in a national shortage, but individual pharmacies may be temporarily out of stock. medfinder can call pharmacies near you to find which ones have your exact dosage in stock and text you the results. Check out our guide to finding dicyclomine in stock near you for more tips.