Cefixime Is an Oral Antibiotic Used to Treat UTIs, Ear Infections, Strep Throat, Bronchitis, and Gonorrhea

Cefixime (brand name Suprax) is a third-generation cephalosporin antibiotic taken by mouth. It's one of the go-to oral antibiotics for treating common bacterial infections in adults and children, and it's been in use in the United States since its original FDA approval. Here's everything you need to know about Cefixime in 2026.

What Is Cefixime?

Cefixime is a prescription antibiotic that belongs to the cephalosporin class—specifically the third generation, which means it has a broader spectrum of activity against gram-negative bacteria compared to older cephalosporins like Cephalexin (Keflex).

• Generic name: Cefixime
• Brand name: Suprax
• Drug class: Third-generation cephalosporin antibiotic
• Manufacturers: Lupin Pharmaceuticals, Aurobindo Pharma (generic); originally Wyeth/Lederle (brand)
• Controlled substance: No — Cefixime is not a controlled substance
• Generic available: Yes

Cefixime works by disrupting bacterial cell wall synthesis, which causes bacteria to break apart and die. It's effective against many common bacteria that cause infections in the ears, throat, lungs, urinary tract, and reproductive system.

What Is Cefixime Used For?

Cefixime is FDA-approved to treat the following infections:

• Uncomplicated urinary tract infections (UTIs) — Bladder infections caused by susceptible bacteria like E. coli.
• Otitis media (ear infections) — One of the most common prescriptions for middle ear infections in children.
• Pharyngitis and tonsillitis (strep throat) — Caused by Streptococcus pyogenes. Often used as an alternative to penicillin or amoxicillin.
• Acute exacerbations of chronic bronchitis — When chronic bronchitis flares up due to a bacterial infection.
• Uncomplicated gonorrhea — Cervical and urethral gonorrhea infections.

Doctors also prescribe Cefixime off-label for sinusitis, typhoid fever, and occasionally as an alternative treatment for Lyme disease.

How Is Cefixime Taken?

Cefixime comes in several forms to fit different patients' needs:

• Oral capsule: 400 mg
• Oral tablet: 400 mg
• Chewable tablets: 100 mg, 150 mg, 200 mg
• Oral suspension (liquid): 100 mg/5 mL, 200 mg/5 mL, 500 mg/5 mL

Typical Dosing

• Adults: 400 mg once daily, or 200 mg twice daily
• Children (6 months and older): 8 mg/kg/day, given once daily or split into two doses

How to Take It

• Can be taken with or without food.
• Capsules should be swallowed whole—don't crush or chew them.
• Chewable tablets must be chewed completely before swallowing.
• Oral suspension should be shaken well before each dose.
• Complete the full course of treatment, even if you feel better after a few days. Stopping early promotes antibiotic resistance.

Treatment length varies by infection type, typically ranging from 5 to 14 days. Your doctor will specify the exact duration.

Who Should Not Take Cefixime?

Cefixime is not appropriate for everyone. You should not take Cefixime if you:

• Have a known allergy to Cefixime or any cephalosporin antibiotic.
• Have a history of severe allergic reaction (anaphylaxis) to penicillin or other beta-lactam antibiotics — there is a risk of cross-reactivity.

Use with caution if you have:

• Kidney disease — Dose adjustment is required if creatinine clearance is 20 mL/min or lower.
• Phenylketonuria (PKU) — The chewable tablets contain phenylalanine.
• Diabetes — The oral suspension contains sucrose.
• History of GI disease, especially colitis — Cefixime can increase the risk of C. difficile-associated diarrhea.

Always tell your doctor about all your allergies, medical conditions, and current medications before starting Cefixime. For a detailed list of drug interactions, see our guide on Cefixime drug interactions.

How Much Does Cefixime Cost?

The cost of Cefixime depends on whether you're getting the generic or brand-name version, and whether you have insurance:

• Generic Cefixime (without insurance): $14–$85 for a typical course (e.g., 2 capsules of 400 mg)
• Brand-name Suprax (without insurance): $50–$250+ depending on formulation
• With a discount card (GoodRx, SingleCare): As low as $14–$20 for generic
• With insurance: Generic Cefixime is typically on Tier 2 (preferred generic), so copays are usually $5–$30

Medicare Part D generally covers generic Cefixime. Brand-name Suprax may require prior authorization or step therapy.

For a complete breakdown of savings options, see our guide: How to Save Money on Cefixime.

Common Side Effects

The most common side effects of Cefixime include diarrhea (up to 16% of patients), nausea, abdominal pain, headache, and gas. Serious side effects are rare but include severe allergic reactions, C. difficile-associated diarrhea, and severe skin reactions. For the full breakdown, read our detailed guide on Cefixime side effects.

Final Thoughts

Cefixime is a well-established, effective antibiotic for common bacterial infections. It's available in generic form, comes in multiple formulations (including a liquid for children), and can be taken once daily—making it convenient for most patients.

If you've been prescribed Cefixime, make sure you know what side effects to watch for, check for drug interactions, and find the best price before filling your prescription. Need help finding it in stock? Medfinder can help you locate Cefixime at a pharmacy near you.