Everything you need to know about Amlodipine/Hydrochlorothiazide/Valsartan (Exforge HCT) — what it is, what it treats, available dosages, costs, and key safety info for 2026.
Amlodipine/Hydrochlorothiazide/Valsartan is a prescription medication that combines three blood pressure drugs into a single daily tablet, prescribed for adults whose hypertension isn't adequately controlled by one or two medications alone.
If you or someone you know has been prescribed this medication — or if you're just trying to understand what it is — this guide covers everything from what it does to how much it costs in 2026.
The brand-name version is Exforge HCT, manufactured by Novartis Pharmaceuticals. The generic version — Amlodipine/Hydrochlorothiazide/Valsartan (sometimes written as Amlodipine/Valsartan/HCTZ) — is also widely available and significantly less expensive.
This is a combination antihypertensive medication containing three distinct drug classes:
Each component attacks high blood pressure from a different angle, which is why this medication is so effective for patients who need more than one or two drugs to reach their blood pressure goals.
Exforge HCT was approved by the FDA for the treatment of hypertension. It's indicated for patients whose blood pressure isn't adequately controlled by any two of the three individual components, or for patients already stabilized on all three components as separate pills who want the convenience of a single tablet.
Amlodipine/Hydrochlorothiazide/Valsartan is not a controlled substance. It has no abuse potential and does not require special prescribing procedures.
The primary (and essentially only) use for this medication is treating hypertension (high blood pressure).
High blood pressure is sometimes called the "silent killer" because it rarely causes symptoms but steadily damages your heart, blood vessels, kidneys, and brain over time. Left untreated, it significantly increases your risk of heart attack, stroke, kidney failure, and vision loss.
Amlodipine/Hydrochlorothiazide/Valsartan is typically prescribed when:
This isn't a first-line medication — meaning your doctor will usually try single drugs or two-drug combinations before moving to a triple combo. For more on how this medication works, see our mechanism of action guide.
Amlodipine/Hydrochlorothiazide/Valsartan comes as an oral tablet in five strengths:
The numbers represent the amounts of Amlodipine/Valsartan/Hydrochlorothiazide in each tablet, respectively.
You may notice some blood pressure lowering within the first few days, but the full effect typically takes about 2 weeks. Your doctor may increase your dose after this initial period if your blood pressure hasn't reached its target.
Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and take your next one at the regular time. Do not take two doses at once to make up for a missed one.
Amlodipine/Hydrochlorothiazide/Valsartan is not safe for everyone. Do not take this medication if you:
Use with caution in older adults, patients with liver disease, and patients with existing kidney problems. Your doctor will order regular blood work to monitor kidney function and electrolyte levels. For a complete list of side effects and safety information, see our detailed guide.
Cost is a real factor for many patients, especially with a medication you'll take every day for the foreseeable future.
Without insurance, brand-name Exforge HCT costs approximately $160 to $400 per month for a 30-day supply. Novartis offers a Patient Savings Co-Pay Card for eligible commercially insured patients — visit copay.novartispharma.com for details.
The generic version of Amlodipine/Hydrochlorothiazide/Valsartan costs $70 to $150 per month without insurance. With discount cards like GoodRx or SingleCare, prices can drop to $30 to $72 for a 30-day supply.
The generic is typically covered by most insurance plans, including Medicare Part D and commercial insurance, usually on a Tier 2 or Tier 3 formulary. Brand-name Exforge HCT may require prior authorization or step therapy.
If you're uninsured or experiencing financial hardship, the Novartis Patient Assistance Foundation offers free medication to qualifying patients. You can also find assistance through NeedyMeds and RxAssist. For a full breakdown of savings options, check our savings guide.
Amlodipine/Hydrochlorothiazide/Valsartan is a powerful triple-combination medication that tackles high blood pressure from three different angles. It's designed for patients who need more than one or two drugs to get their blood pressure under control, and it simplifies treatment by combining three medications into a single daily tablet.
Like any medication, it comes with important safety considerations — particularly the pregnancy warning and the need for regular lab monitoring. But for many patients with resistant hypertension, it's an effective and convenient option.
Need help finding this medication or comparing prices? Visit Medfinder to search pharmacies near you.
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