Is Symproic in Shortage in 2026?

If you've been struggling to find Symproic (Naldemedine) at your pharmacy, you may be wondering: is there an official shortage? The short answer is no — Symproic is not currently listed in an FDA drug shortage. But that doesn't mean it's easy to find.

Many patients report difficulty filling their Symproic prescriptions, not because of a manufacturing shortage, but because of limited pharmacy stocking. In this update, we'll explain what's going on with Symproic availability in 2026 and what you can do about it.

Why Is Symproic Hard to Find If There's No Shortage?

There's an important difference between a drug shortage (where the manufacturer can't produce enough supply) and a stocking issue (where pharmacies choose not to carry a particular medication). With Symproic, the problem is mostly the latter.

Here's why:

• No generic available: Naldemedine is only available as brand-name Symproic. Without generics on the market, there's a single supply chain, and pharmacies may be less likely to stock it.
• Niche indication: Symproic is prescribed specifically for opioid-induced constipation in adults with chronic non-cancer pain. This is a relatively small patient population compared to drugs for diabetes or blood pressure.
• High cost: At $484 to $746 per month without insurance, Symproic is expensive. Pharmacies may not want to tie up inventory dollars in a high-cost, low-volume medication.
• Prior authorization requirements: Many insurance plans require prior authorization or step therapy before covering Symproic, which reduces the number of prescriptions that actually get filled.

For a deeper dive into these factors, read our post on why Symproic is so hard to find.

How Much Does Symproic Cost in 2026?

The cost of Symproic hasn't come down significantly since its launch. Here's what you can expect:

• Average retail (cash) price: approximately $550–$746 for 30 tablets (a one-month supply)
• With a GoodRx coupon: as low as approximately $484
• With manufacturer copay card: eligible commercially insured patients may pay as little as $0

If cost is a barrier for you, we have a full guide on how to save money on Symproic, including coupons, discount programs, and patient assistance options.

Are There New Treatment Options for OIC in 2026?

The landscape for opioid-induced constipation treatment continues to evolve. While Symproic remains an effective option, there are several other medications available:

• Movantik (Naloxegol): Another PAMORA, taken once daily on an empty stomach
• Relistor (Methylnaltrexone): Available as an injection or oral tablet
• Amitiza (Lubiprostone): Works through a different mechanism (chloride channel activation)

Your doctor can help determine which medication is the best fit based on your insurance coverage, medical history, and personal preference. Read our full guide to Symproic alternatives for more details.

How to Find Symproic in Stock Right Now

If you need Symproic and your pharmacy doesn't have it, here's what to do:

1. Search on Medfinder: Use Medfinder to check which pharmacies near you currently have Symproic in stock. It's free and faster than calling around.
2. Try independent pharmacies: They often have more flexibility in ordering specialty medications from different wholesalers.
3. Ask about mail-order: Your insurance may cover Symproic through a mail-order pharmacy, which can deliver it directly to your door.
4. Plan ahead: Request refills a few days before you run out so the pharmacy has time to order if needed.

For more strategies, check out our detailed guide on how to find Symproic in stock near you.

Final Thoughts

While Symproic is not in an official FDA shortage in 2026, it remains a difficult medication to find at many pharmacies. The combination of brand-only status, high cost, and niche demand creates real challenges for patients who depend on it.

The key is to be proactive: use tools like Medfinder, explore independent pharmacies, look into savings programs, and keep an open dialogue with your doctor about alternatives if needed.

You shouldn't have to suffer from opioid-induced constipation just because your medication is hard to find. Help is available.