Symproic costs up to $746/month without insurance. Learn how to save with coupons, discount cards, copay programs, and patient assistance in 2026.
If you've been prescribed Symproic (Naldemedine) for opioid-induced constipation, you may have experienced sticker shock at the pharmacy. With a cash price of up to $746 for a 30-day supply, Symproic is one of the more expensive medications for OIC.
The good news? You don't necessarily have to pay full price. This guide covers every major way to save money on Symproic in 2026, from manufacturer copay cards to discount programs and patient assistance.
Here's what you can expect to pay for a one-month supply (30 tablets of 0.2 mg) without insurance:
There is no generic version of Naldemedine available in the United States as of 2026, which is a major reason the price remains high. When a generic eventually becomes available, prices could drop significantly — but that hasn't happened yet.
The Symproic Savings Program is the best deal available for patients with commercial insurance. Here's how it works:
Who qualifies:
If you have commercial insurance, this should be your first stop. Even if your insurance covers Symproic, the copay card can eliminate whatever copay remains.
If you don't have insurance — or your insurance doesn't cover Symproic — prescription discount cards can bring the price down. These are free to use and accepted at most pharmacies:
Additional discount cards worth checking include:
Prices can vary significantly between pharmacies even with the same discount card, so it's worth comparing prices at multiple locations. Some independent pharmacies may offer lower prices than chains.
If you're uninsured or underinsured and can't afford Symproic even with discount cards, patient assistance programs (PAPs) may be able to help. These programs provide medication at reduced cost or free of charge to qualifying patients.
Contact the manufacturer (BioDelivery Sciences / Collegium Pharmaceutical) to ask about patient assistance options for uninsured patients. Information may be available through the Symproic website or by calling their patient support line.
Eligibility for these programs typically depends on your income level, insurance status, and residency. Application processes vary but are generally straightforward.
If you have health insurance, check whether Symproic is on your plan's formulary (drug list). If it's covered, you'll pay a copay rather than the full cash price. Keep in mind:
Many insurance plans offer lower copays for 90-day supplies through mail-order pharmacies. If your plan covers Symproic, getting a 90-day supply by mail can save you money compared to filling monthly at a retail pharmacy.
If Symproic is too expensive even with savings programs, ask your doctor about alternative OIC medications. Depending on your insurance, a different medication may be covered at a lower tier or may have its own savings programs:
It may be tempting to take Symproic every other day to stretch your supply, but this is not recommended. The medication is designed to be taken once daily for consistent relief. Skipping doses may reduce its effectiveness and worsen your OIC symptoms. If cost is forcing you to ration your medication, talk to your doctor about more affordable alternatives.
Here's a quick checklist to maximize your savings on Symproic:
No one should have to go without treatment for opioid-induced constipation because of cost. While Symproic is an expensive medication, there are real ways to bring the price down — sometimes all the way to $0.
Start with the manufacturer copay card if you have commercial insurance. If you don't, explore discount cards and patient assistance programs. And if you're having trouble finding Symproic at your pharmacy, use Medfinder to check availability near you.
For more information about Symproic, check out our guides on what Symproic is, side effects to watch for, and how to find it in stock.
You focus on staying healthy. We'll handle the rest.
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