The Progesterone Shortage: Where Do Things Stand in 2026?

If you take Progesterone — whether for menopause, amenorrhea, or fertility — you've probably been affected by the shortage that's been disrupting supply for the past several years. The question on everyone's mind: is it getting better?

Here's what we know heading into 2026, along with practical steps you can take to protect your access to this important medication.

Is Progesterone Still in Shortage?

Yes. As of early 2026, the American Society of Health-System Pharmacists (ASHP) continues to list three forms of Progesterone on its drug shortage database:

• Progesterone oral capsules (generic and Prometrium)
• Progesterone injection (Progesterone in oil)
• Progesterone vaginal inserts (Endometrin)

The capsule shortage has been driven by some manufacturers experiencing production disruptions. Aurobindo, one of the generic suppliers, has not provided availability information. Amneal and Virtus (which manufactures brand-name Prometrium) continue to supply capsules, but demand sometimes outpaces supply.

For the injectable form, the shortage has been more persistent. American Regent stopped marketing Progesterone injection entirely. Other suppliers like AuroMedics and Hikma have product available, but manufacturing delays and increased demand have created gaps.

Vaginal inserts (Endometrin) have also been listed on the ASHP shortage database, adding to the challenge for fertility patients who rely on this specific formulation.

Why Is Progesterone Hard to Find?

The shortage comes down to a few interconnected problems:

• Manufacturer exits: When companies like American Regent stop making a product, the remaining manufacturers can't always absorb the extra demand overnight.
• Production delays: Even active manufacturers have experienced setbacks related to raw material sourcing and quality control.
• Surging demand: More patients are using Progesterone than ever — driven by growing use of IVF, increased awareness of bioidentical hormone therapy, and an aging population needing menopausal hormone management.
• Non-interchangeable formulations: You can't easily swap oral capsules for vaginal inserts or vice versa, so a shortage in one form doesn't get relieved by surplus in another.

For a deeper dive, read why Progesterone is so hard to find.

How Much Does Progesterone Cost in 2026?

Cost varies significantly depending on the formulation and whether you have insurance:

• Generic oral capsules (100 mg, 30 count): Retail price around $79. With a GoodRx or SingleCare coupon, as low as $14-$30.
• Brand-name Prometrium (100 mg, 90 count): Around $200-$422 without insurance.
• Crinone vaginal gel (8%): $200-$350 per box.
• Endometrin vaginal inserts: $300-$600 per cycle without insurance.
• Progesterone injection: Prices vary; typically $50-$150 per vial depending on supplier and pharmacy.

Generic Progesterone capsules are covered by most insurance plans and Medicare Part D, usually on Tier 1 or Tier 2. Vaginal formulations may require prior authorization. For cost-saving tips, see our guide on how to save money on Progesterone.

Are There New Options or Updates?

While no entirely new Progesterone products have launched recently, here are some developments worth noting:

• Compounding pharmacies have stepped in to help fill the gap, preparing custom Progesterone suppositories and creams when commercial products are unavailable. While these aren't FDA-approved, they can be a viable bridge during shortages.
• Telehealth prescribing has made it easier to get a Progesterone prescription if you can't see your regular doctor in person. Many OB/GYN and primary care providers now offer telehealth visits for hormone therapy management.
• Pharmacy stock-tracking tools like Medfinder have become essential for patients navigating shortages. Instead of calling pharmacy after pharmacy, you can check availability online.

How to Find Progesterone in Stock Right Now

Here are the most effective strategies:

1. Check Medfinder: Search for Progesterone availability at pharmacies near you at Medfinder.com.
2. Try independent pharmacies: They often have access to different distributors and may have stock when chains don't.
3. Ask about specialty pharmacies: Especially for fertility-related forms (vaginal inserts, gel, injections).
4. Consider compounding: Ask your doctor if a compounded Progesterone product could work for your situation.
5. Refill early: Don't wait until you're out. Request refills 7-10 days before your current supply runs out.

For more detailed tips, read our full guide on how to find Progesterone in stock near you.

Final Thoughts

The Progesterone shortage continues to affect patients in 2026, but it's not hopeless. Supply is available — it's just not always at the most convenient pharmacy. By using the right tools, exploring different pharmacy options, and working closely with your doctor, you can stay on track with your treatment.

If Progesterone remains truly unavailable for you, discuss alternatives to Progesterone with your provider. And if you need help finding a prescriber, check out our guide on how to find a doctor who can prescribe Progesterone.