Progesterone Doesn't Have to Break the Bank

If you've ever looked at the price tag on a Progesterone prescription and felt a twinge of sticker shock, you're not alone. Depending on which formulation you take and whether you have insurance, Progesterone can cost anywhere from $14 to over $600 per month.

The good news? There are multiple ways to bring that cost down significantly. In this guide, we'll walk through the actual prices you can expect to pay in 2026, plus every major way to save — from free coupon cards to patient assistance programs.

How Much Does Progesterone Cost Without Insurance?

Let's start with the numbers. Here's what you might pay out of pocket at a retail pharmacy without insurance or coupons:

• Generic Progesterone oral capsules (100 mg, 30 count): ~$79 retail
• Generic Progesterone oral capsules (200 mg, 30 count): ~$90-$120 retail
• Brand-name Prometrium (100 mg, 90 count): ~$200-$422
• Crinone vaginal gel (8%, 6 applicators): ~$200-$350
• Endometrin vaginal inserts (100 mg, 21 count): ~$300-$600
• Progesterone injection (50 mg/mL, 10 mL vial): ~$50-$150

The cost difference between generic oral capsules and specialty formulations like vaginal inserts is dramatic. If you're taking Progesterone for fertility treatment and need daily vaginal inserts, your monthly cost could easily exceed $500 without help.

Coupons and Discount Cards: Your First Line of Savings

For generic Progesterone capsules, pharmacy discount cards can reduce the price by 60-80%. These cards are free to use and accepted at most major pharmacies:

GoodRx

GoodRx often shows generic Progesterone capsules (100 mg, 30 count) for as low as $14-$20 at pharmacies like Costco, Kroger, and Walmart. That's an 75-80% savings off the retail price. Simply search for Progesterone on GoodRx.com, select your dose and quantity, and show the coupon at the pharmacy counter.

SingleCare

SingleCare offers comparable pricing, with generic Progesterone capsules frequently available for $15-$25. SingleCare is accepted at CVS, Walgreens, Walmart, and many other chains.

Other Discount Cards

Several other free discount programs can help bring down costs:

• RxSaver: Compare prices across pharmacies in your area
• Optum Perks: Often offers competitive pricing on generics
• BuzzRx: Free savings card accepted at most pharmacies
• America's Pharmacy: Another option for comparing discount prices
• ScriptSave WellRx: Free membership with pharmacy discounts

Important tip: Discount card prices vary by pharmacy. The same coupon might get you Progesterone for $14 at Costco but $35 at CVS. Always compare prices across multiple pharmacies using one of these tools before filling your prescription.

Do Discount Cards Work for Brand-Name Prometrium?

Discount cards generally offer more modest savings on brand-name Prometrium. You might save 10-20%, bringing the price from $400+ down to $300-$350. For brand-name savings, look into whether your insurance will cover Prometrium or consider switching to generic (which is therapeutically equivalent).

Patient Assistance Programs

If you're uninsured or underinsured and struggling to afford Progesterone, patient assistance programs (PAPs) may help:

Prescription Hope

Prescription Hope works with pharmaceutical manufacturers to provide Prometrium for a flat fee of $70 per month to qualifying patients. They handle the application process and deliver medication directly to you.

NeedyMeds

NeedyMeds (needymeds.org) maintains a database of patient assistance programs, discount cards, and other resources for people who can't afford their medications. Search for "Progesterone" to see current options.

RxAssist

RxAssist (rxassist.org) is another comprehensive database of patient assistance programs. It can help you identify manufacturer programs, state programs, and nonprofit assistance specific to your situation.

RxHope

RxHope (rxhope.com) connects patients with manufacturer assistance programs. You can search by medication name and apply directly through their platform.

State Pharmaceutical Assistance Programs

Many states operate their own prescription assistance programs for residents who meet income requirements. These can supplement Medicare or fill gaps for uninsured patients. Check with your state's health department for details.

Other Ways to Save on Progesterone

Switch to Generic

If you're currently taking brand-name Prometrium, switching to generic Progesterone capsules can save you hundreds of dollars per month. Generic Progesterone is therapeutically equivalent to Prometrium — it contains the same active ingredient in the same dose. The main difference is that Prometrium capsules contain peanut oil, while some generics use a different oil base (important for peanut-allergic patients). Ask your doctor and pharmacist about the generic option.

Request a 90-Day Supply

Many insurance plans and discount programs offer a lower per-unit price for 90-day fills compared to 30-day fills. For example, if Progesterone costs $20 for 30 capsules with a coupon, a 90-day supply might cost $45-$50 rather than $60. Ask your pharmacy about 90-day pricing.

Try Costco or Walmart Pharmacy

Costco pharmacies consistently offer some of the lowest cash prices on generic medications — and you don't need a Costco membership to use the pharmacy. Walmart's pharmacy also frequently has competitive pricing on generics. For Progesterone capsules, Costco pricing with a discount card is often the lowest available.

Use Mail-Order Pharmacy

Mail-order pharmacies can offer lower prices, especially for maintenance medications. Amazon Pharmacy, Honeybee Health, and Cost Plus Drugs are worth checking. Cost Plus Drugs in particular offers transparent, low-markup pricing on many generics.

Ask About Manufacturer Copay Assistance

While no active manufacturer savings card has been identified for Prometrium specifically, it's worth asking your doctor or pharmacist about any new programs that may have launched. The availability of copay cards changes frequently.

Consider a Compounded Version

If you need vaginal Progesterone and Crinone or Endometrin are too expensive, a compounding pharmacy can often prepare Progesterone suppositories or creams for $30-$100 per month — significantly less than the $200-$600 you might pay for commercial vaginal products. Discuss this option with your prescriber.

Insurance Tips

If you have health insurance, here are some tips to maximize your coverage:

• Check your formulary: Generic Progesterone capsules are on most formularies at Tier 1 or Tier 2, which means low copays (often $5-$20).
• Prior authorization: Brand-name Prometrium, Crinone, and Endometrin may require prior authorization. Ask your doctor's office to handle this proactively.
• Step therapy: Some insurers require you to try oral Progesterone before covering vaginal formulations. If you need vaginal Progesterone for fertility, your doctor can usually get an exception.
• Fertility coverage: If you're using Progesterone for IVF, check whether your state mandates fertility coverage. States like Massachusetts, Connecticut, and Illinois require certain insurers to cover fertility treatments, including medications.

Final Thoughts

No one should have to skip their Progesterone because of cost. With generic options as low as $14 with a coupon, plus patient assistance programs for those who need extra help, there are real ways to make this medication affordable.

Start by comparing prices with GoodRx or SingleCare, ask your doctor about generic substitution, and explore patient assistance programs if you're uninsured. If you're also having trouble finding Progesterone in stock, use Medfinder to check pharmacy availability near you.

For more on the current shortage, read our Progesterone shortage update for 2026. And for a complete overview of the medication, check out What is Progesterone? Uses, dosage, and what you need to know.