Prochlorperazine interacts with many common medications. Learn which drugs to avoid, what to tell your doctor, and how to stay safe.
Prochlorperazine affects several systems in your body at once. It blocks dopamine, histamine, acetylcholine, and alpha-adrenergic receptors (learn more about how Prochlorperazine works). Because it has such broad activity, it can interact with many other medications — sometimes in ways that cause serious problems.
Knowing about these interactions before you start Prochlorperazine helps keep you safe. Always share your complete medication list with your doctor and pharmacist, including over-the-counter drugs, supplements, and herbal products.
This is the most important interaction category. Prochlorperazine causes drowsiness on its own. Combining it with other substances that depress the central nervous system (CNS) can cause dangerously increased sedation.
What to do: Tell your doctor about any of these medications. Your doctor may need to adjust doses or monitor you more closely. Never drink alcohol while taking Prochlorperazine.
Prochlorperazine already has anticholinergic effects (dry mouth, constipation, blurred vision). Adding another anticholinergic medication on top can amplify these effects to dangerous levels.
Prochlorperazine can affect the electrical activity of your heart by prolonging the QT interval. Combining it with other medications that also prolong the QT interval increases the risk of a dangerous heart rhythm called torsades de pointes.
What to do: Your doctor should review your full medication list for QT-prolonging drugs before starting Prochlorperazine. If you take any of these, they may choose a different antiemetic or monitor your heart with an ECG. Learn about your side effect risks so you know what heart-related symptoms to watch for.
Prochlorperazine blocks dopamine receptors. Dopamine agonists do the opposite — they activate dopamine receptors. These medications work against each other when combined.
What to do: If you have Parkinson's disease and need an anti-nausea medication, your doctor should use an antiemetic that doesn't block dopamine — such as Ondansetron (Zofran). See our guide on Prochlorperazine alternatives.
Prochlorperazine can lower blood pressure. If you already take blood pressure medication, the combined effect can cause your blood pressure to drop too low.
Combining Prochlorperazine with lithium can be problematic. Prochlorperazine may reduce how well lithium is absorbed, and the combination can increase the risk of extrapyramidal symptoms (movement-related side effects) and neurotoxicity.
What to do: If you take lithium, your doctor should monitor your lithium levels and watch for signs of neurotoxicity such as confusion, tremor, and coordination problems.
Prochlorperazine lowers the seizure threshold, meaning it makes seizures more likely. If you take seizure medication, Prochlorperazine can reduce its effectiveness.
What to do: Your doctor may need to adjust your anticonvulsant dose or choose a different anti-nausea medication.
This is a critical interaction. Prochlorperazine can cause a paradoxical reaction with epinephrine — instead of raising blood pressure (which epinephrine normally does), the combination can cause blood pressure to drop dangerously.
What to do: If you need a vasopressor while on Prochlorperazine, healthcare providers should use norepinephrine instead of epinephrine. Make sure your medical team knows you take Prochlorperazine.
If you're looking for a doctor who can help manage your prescriptions safely, read our guide on finding a doctor who prescribes Prochlorperazine. Having trouble finding the medication? Use MedFinder to check pharmacy stock, or learn about the current shortage situation. For cost savings, see our guide on Prochlorperazine coupons and discounts.
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