How to Save Money on Midazolam in 2026: Coupons, Discounts, and Patient Assistance

The cost of midazolam depends heavily on which formulation you need. Generic injectable midazolam used in hospitals is relatively inexpensive, but Nayzilam — the branded midazolam nasal spray prescribed for outpatient seizure rescue — can cost $640 to $800 or more per fill without insurance. Here's everything you need to know about cutting your midazolam costs in 2026.

How Much Does Midazolam Cost?

Midazolam pricing varies dramatically by formulation:

Generic injectable midazolam (1 mg/mL, 50 mL vial): From approximately $9–$15 per vial at retail — primarily a hospital supply item not commonly dispensed at retail pharmacies

Midazolam 5 mg/mL vials: From approximately $15 per 20 mL vial; with SingleCare, a 10 mg/2 mL vial may cost as low as $3–$12

Midazolam oral syrup (2 mg/mL, 118 mL): Approximately $65 at retail

Nayzilam nasal spray (5 mg/spray, 2-unit device): Average retail price approximately $800 per fill; with GoodRx approximately $640; with UCB savings card, eligible commercially insured patients may pay significantly less

Nayzilam Savings: The UCB Patient Savings Card

UCB, the manufacturer of Nayzilam, offers a Patient Savings Card that can significantly reduce out-of-pocket costs for eligible commercially insured patients. Here's what you need to know:

Eligible patients pay as little as $0 to a defined out-of-pocket maximum per prescription with the Nayzilam savings card

Eligibility typically requires commercial (not government) insurance coverage

To access the savings card, call 1-888-786-5879 or visit nayzilam.com/savings

Program terms and income/insurance eligibility requirements apply

UCB Patient Assistance Program (PAP)

If you are uninsured or underinsured and cannot afford Nayzilam, UCB operates a Patient Assistance Program (PAP) that may provide the medication at little or no cost to eligible patients. To apply:

Call UCB patient support at 1-888-786-5879

Visit the UCB patient assistance enrollment portal at ucb-pap.enrollsource.com

Have your insurance information (or lack thereof), income documentation, and prescription ready

GoodRx and Prescription Discount Cards

GoodRx can reduce the cost of generic midazolam injectable and oral syrup formulations at participating pharmacies. For Nayzilam nasal spray, GoodRx shows prices around $640 for the 2-unit (2 x 5 mg) device — approximately 20% below the average retail price of $800. Always compare GoodRx prices against your insurance copay to find the best deal.

SingleCare is another discount card that works at pharmacies including Walgreens, CVS, Walmart, Kroger, and more. For generic midazolam vials, SingleCare has shown prices as low as $3.20 per 10 mg/2 mL vial.

Does Insurance Cover Midazolam?

Coverage depends on formulation and setting:

Hospital/procedural use: Midazolam administered in a hospital, surgery center, or clinical setting is typically billed through medical insurance (not the pharmacy benefit) as part of the procedure. Your share depends on your deductible and out-of-pocket status.

Nayzilam (nasal spray): Covered under the pharmacy benefit. Typically placed on Tier 3 or higher (specialty tier) on most formularies. Prior authorization is commonly required. Some insurers require step therapy (documenting a trial of another rescue medication first).

Midazolam oral syrup: Typically covered under pharmacy benefit when prescribed; generic availability keeps costs manageable.

Tips for Getting Nayzilam Covered by Insurance

Ask your neurologist to submit a prior authorization with detailed documentation of your seizure history and why rescue therapy is medically necessary

If denied, request a formal appeal — denials are frequently overturned with proper clinical documentation

Use UCB's patient support team to help with prior authorization paperwork at 1-888-786-5879

While the PA is pending, ask about bridge supply options through UCB's program

Once you have your prescription ready, see our guide on How to Find Midazolam in Stock Near You to find a pharmacy that has it.