Estradiol/Norethindrone/Relugolix (Myfembree) costs up to $1,700/month without insurance. Learn how to save with copay cards, discount coupons, and patient assistance in 2026.
Estradiol/Norethindrone/Relugolix, sold under the brand name Myfembree, is one of the more expensive prescription medications for uterine fibroids and endometriosis. Without insurance, you're looking at a cash price of $1,300 to $1,700 per month for a 28-tablet supply.
That's a significant financial burden — especially for a medication you may need to take for up to 24 months. But don't let the price tag discourage you from getting the treatment you need. There are several legitimate ways to reduce your out-of-pocket costs, from manufacturer copay cards to discount programs and patient assistance.
Here's a complete breakdown of how to save money on Myfembree in 2026.
The retail (cash) price for Myfembree varies by pharmacy, but here's what you can expect in 2026:
These prices make Myfembree one of the costlier medications in its class. For context, the alternative Oriahnn costs roughly $1,000–$1,500/month, and injectable Lupron Depot ranges from $1,000–$1,800 per injection. There is currently no generic version of Myfembree available, which keeps the price high.
If you have commercial (private) health insurance, the manufacturer's copay assistance program is likely your best savings opportunity.
This program can reduce your annual Myfembree cost from over $15,000 to as little as $60 per year (12 monthly fills at $5 each). It's worth enrolling even if your insurance copay is manageable — the savings card stacks on top of your insurance coverage to reduce your out-of-pocket amount.
If you don't have insurance or prefer to pay cash, prescription discount cards can help reduce the price. These are not insurance — they're free programs that negotiate lower prices with pharmacies.
Important note: Discount cards and coupons cannot be combined with insurance copays or government insurance. They're most useful for uninsured patients or those paying cash.
If you're uninsured, underinsured, or experiencing financial hardship, patient assistance programs can provide Myfembree at little or no cost.
Myovant Sciences (the manufacturer) offers a patient assistance program for eligible patients who cannot afford their medication. Contact Myovant patient services to inquire about eligibility and apply.
These programs typically require proof of income, insurance status, and a valid prescription. Application processing can take 2–4 weeks, so apply as early as possible if you think you'll need help.
If your insurance denies coverage for Myfembree, you have the right to appeal. Ask your doctor to submit a letter of medical necessity explaining why Myfembree is the appropriate treatment for your condition. Include details about any other treatments you've tried that were ineffective or caused side effects.
Some insurance plans require step therapy — trying cheaper alternatives first. If you've already tried other treatments (hormonal contraceptives, NSAIDs, or tranexamic acid) and they didn't work, your doctor can request a step therapy exception to go directly to Myfembree.
Your insurance plan may offer lower copays through their designated specialty pharmacy compared to retail pharmacies. Ask your insurance company which specialty pharmacy is in-network and what your expected copay would be.
Some insurance plans offer better pricing for 90-day supplies through mail-order specialty pharmacies. This can save money compared to filling 30-day supplies at retail. Combined with the copay card ($15 for a 90-day supply), this can be very cost-effective.
Myfembree's patent exclusivities have begun expiring, and a generic version could become available in 2026. A generic would likely cost significantly less — potentially reducing the cash price by 50% or more. Check with your pharmacist periodically for updates. For the latest on availability, read our shortage update for 2026.
Estradiol/Norethindrone/Relugolix (Myfembree) is an effective treatment for uterine fibroids and endometriosis, but the cost can be a real barrier. The good news is that between the manufacturer's copay assistance program, discount cards, and patient assistance programs, most patients can find a way to make it affordable.
Start with the manufacturer's copay card if you have commercial insurance — it's the single biggest savings opportunity, potentially reducing your cost to just $5 per month. If you're uninsured, look into patient assistance programs and discount cards to bring the price down as much as possible.
Need help finding Myfembree in stock near you? Use Medfinder to check pharmacy availability. And for more information about this medication, explore our guides on what Estradiol/Norethindrone/Relugolix is, side effects, and drug interactions.
You focus on staying healthy. We'll handle the rest.
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