Duavee costs $300-$500/month without insurance. Learn how to save with Pfizer's co-pay card, patient assistance programs, discount cards, and more in 2026.
If you've looked at the price of Duavee and felt your heart sink, you're not alone. Duavee (conjugated estrogens 0.45 mg/bazedoxifene 20 mg) costs between $300 and $500 per month without insurance — and because there's no generic version, there's no cheaper equivalent sitting on the shelf.
But that doesn't mean you have to pay full price. In this guide, we'll walk you through every option available in 2026 to reduce your out-of-pocket cost for Duavee, from manufacturer savings programs to discount cards to patient assistance for those who qualify.
The retail (cash) price for a 30-day supply of Duavee typically ranges from $300 to $500, depending on the pharmacy. This makes it one of the more expensive hormone replacement therapies on the market.
Here's how that compares to alternatives:
The high cost of Duavee is directly tied to its lack of generic competition. Because Pfizer is the only manufacturer, there's no lower-cost version available.
With insurance, your cost depends on your plan's formulary placement:
Many plans require prior authorization before covering Duavee, and some require step therapy (trying a cheaper alternative first). If your plan denies coverage, your doctor can submit an appeal — especially if you've had side effects or treatment failure with progestin-containing alternatives.
Pfizer offers a co-pay savings card for Duavee that can significantly reduce your out-of-pocket costs. Here are the key details:
If you have commercial insurance, this should be your first stop. The savings card can turn a $100+ copay into something much more manageable.
If you're uninsured or underinsured, Pfizer RxPathways may provide Duavee at no cost. Here's what to know:
This is a genuine lifeline for patients who can't afford their medication. The application process takes some time, so apply as soon as possible — don't wait until you run out of medication.
Prescription discount cards can help reduce the cash price if you're paying out of pocket. Keep in mind that discount card prices for Duavee are still relatively high because there's no generic version, but they can still save you something compared to full retail.
Prices vary by pharmacy, so compare across multiple cards and locations. Sometimes a specific pharmacy-card combination offers a significantly better deal.
Important note: Discount cards cannot be combined with insurance. You use one or the other — whichever gives you the lower price.
Many insurance plans offer lower copays for mail-order prescriptions, especially for 90-day supplies. If your plan covers Duavee, switching to mail-order could save you money while also solving the availability problem. Check with your insurance provider for mail-order options.
Your doctor may have Duavee samples available in their office. While this isn't a long-term solution, it can bridge a gap while you wait for insurance approval or a patient assistance application to process.
If you have an FSA or HSA, you can use pre-tax dollars to pay for Duavee. This effectively gives you a discount equal to your tax rate — potentially saving 20–35% on out-of-pocket costs.
If Duavee's cost is simply unmanageable, talk to your doctor about more affordable alternatives. Generic versions of Prempro ($15–$50/month) and Activella ($20–$60/month) are well-studied options for treating menopausal symptoms and preventing osteoporosis. They use progestin instead of bazedoxifene, which isn't identical to Duavee — but they're effective and much more affordable.
See our full comparison: Alternatives to Duavee if you can't fill your prescription.
Duavee's $300–$500 monthly price tag is a real burden, but most patients can reduce their costs significantly with the right programs. Start with the Pfizer co-pay savings card if you have commercial insurance, or apply for Pfizer RxPathways if you're uninsured.
Don't forget to compare prices across pharmacies using discount cards — and if cost remains a major barrier, have an honest conversation with your doctor about whether an affordable alternative might work for you.
For help finding Duavee in stock, visit Medfinder. And for more about this medication, check out our guides on what Duavee is and Duavee side effects.
You focus on staying healthy. We'll handle the rest.
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