Cyltezo Pen 40 Mg/0.4 Ml Starter Pack Can Be Expensive — But You Have Options

Let's talk about the number that probably brought you here: Cyltezo Pen 40 Mg/0.4 Ml Starter Pack can cost $5,800 to $6,500 per month without insurance. Even with insurance, specialty tier copays can run $200 to $500 or more per fill. That's a significant financial burden, especially for a medication you may need for months or years.

The good news? There are multiple ways to reduce what you pay for Cyltezo in 2026. This guide walks you through every major savings option — from manufacturer copay cards to patient assistance programs to practical tips that can save you hundreds or even thousands of dollars.

What Does Cyltezo Cost Without Insurance?

Here's what you're looking at for Cyltezo Pen 40 Mg/0.4 Ml Starter Pack at full retail price:

• Cash price (no insurance): Approximately $5,800 to $6,500 per month
• Annual cost without assistance: Roughly $70,000 to $78,000 per year

For comparison, the original Humira lists at approximately $6,900 to $7,200 per month. As a biosimilar, Cyltezo is typically 5-15% less expensive at list price, but that discount alone doesn't make it affordable for most uninsured patients.

With Insurance

With commercial insurance, your out-of-pocket cost depends on your plan structure:

• Plans with specialty copay: $100 to $500+ per month
• Plans with coinsurance (e.g., 20-30%): $1,200 to $1,950 per month before out-of-pocket maximum
• Plans with copay accumulator programs: Manufacturer copay assistance may not count toward your deductible or out-of-pocket max, significantly increasing your annual costs

Manufacturer Copay Card From Boehringer Ingelheim

This is the first place to start if you have commercial insurance.

Boehringer Ingelheim offers a Cyltezo copay savings card for eligible commercially insured patients. Key details:

• Potential savings: Pay as little as $0 per month for your Cyltezo prescription
• Annual maximum: Varies by program terms — check the current offer on the Cyltezo website
• Eligibility: Must have commercial (private) insurance. Patients with Medicare, Medicaid, or other government insurance are not eligible
• How to enroll: Through the Cyltezo website, your doctor's office, or by calling Boehringer Ingelheim patient support

Important note about copay accumulators: Some insurance plans use copay accumulator programs that prevent manufacturer copay assistance from counting toward your deductible or out-of-pocket maximum. If your plan has a copay accumulator, you may face high costs once the manufacturer's assistance runs out. Ask your insurance company specifically about this.

Boehringer Ingelheim Cares Foundation (Patient Assistance Program)

If you're uninsured or underinsured, the Boehringer Ingelheim Cares Foundation may provide Cyltezo at no cost.

• Eligibility: U.S. residents without adequate prescription coverage and meeting income guidelines
• What you get: Free Cyltezo medication shipped to your doctor's office or home
• How to apply: Your doctor will need to complete an application form. Processing typically takes 2-4 weeks
• Income limits: Generally available for patients at or below 400% of the federal poverty level, though specific criteria may vary

This is the best option for uninsured patients. Don't skip it — the application is straightforward and the savings are massive.

Coupon and Discount Card Options

For patients who don't qualify for the manufacturer programs, several prescription discount platforms may offer some savings on Cyltezo:

• GoodRx (goodrx.com) — Compare prices and get coupons for specialty medications
• SingleCare (singlecare.com) — Free prescription discount card accepted at many pharmacies
• RxSaver (rxsaver.com) — Search for the best available prices in your area
• Optum Perks (perks.optum.com) — Discounts on thousands of medications

A word of caution: Discount cards have limited impact on specialty biologic pricing. The savings from these cards on a $6,000+ medication may be modest. However, they're always worth checking — even small percentage savings on an expensive drug can add up.

Other Ways to Save on Cyltezo

Ask About Biosimilar Alternatives

If Cyltezo is particularly expensive on your plan, ask your doctor about other adalimumab biosimilars that may have better formulary placement — and therefore lower copays. Products like Amjevita, Hadlima, and Hyrimoz may be preferred on your plan with lower cost-sharing. Read our guide on alternatives to Cyltezo for more details.

Use a Specialty Pharmacy With the Best Price

Not all specialty pharmacies charge the same price. Use Medfinder to compare prices across pharmacies that stock Cyltezo. Even among in-network options, there can be meaningful price differences.

Time Your Prescriptions Around Your Deductible

If you have a plan with a deductible and out-of-pocket maximum, starting Cyltezo early in the plan year can help you hit your out-of-pocket max sooner — meaning the rest of the year's doses may be fully covered.

Apply for State or Nonprofit Assistance

Several organizations help patients with chronic conditions afford their medications:

• NeedyMeds (needymeds.org) — Comprehensive database of patient assistance programs
• RxAssist (rxassist.org) — Directory of pharmaceutical company programs
• The Assistance Fund — Provides copay assistance for specific disease categories
• PAN Foundation — Helps underinsured patients with out-of-pocket costs
• HealthWell Foundation — Grants for specific chronic conditions

Appeal High Copays

If your insurance assigns Cyltezo to a specialty tier with high cost-sharing, you can appeal. Your doctor can submit a letter explaining the medical necessity and requesting a lower tier exception. Success rates vary, but it's always worth trying.

Check for State Programs

Some states have pharmaceutical assistance programs for residents with chronic conditions. These vary by state but can provide additional support beyond federal programs. Check with your state's Department of Health or Department of Insurance.

A Quick Comparison: Savings Options at a Glance

• Cyltezo Copay Card: $0/month for eligible commercially insured patients
• Boehringer Ingelheim Cares Foundation: Free medication for eligible uninsured patients
• Discount cards (GoodRx, SingleCare, etc.): Modest savings, varies by pharmacy
• Nonprofit assistance (PAN, HealthWell, etc.): Copay help for qualifying patients, often $0-$100/month
• Switching to preferred biosimilar: Lower copay if your plan prefers a different adalimumab product

Final Thoughts

No one should have to choose between their health and their finances. Cyltezo Pen 40 Mg/0.4 Ml Starter Pack is an expensive medication, but there are real ways to bring the cost down — sometimes to zero.

Start with the Boehringer Ingelheim copay card if you have commercial insurance, or the Cares Foundation if you're uninsured. Explore nonprofit assistance programs. And always compare prices using Medfinder before filling your prescription.

If cost remains a barrier even after exploring these options, talk to your doctor about alternative adalimumab products that may be more affordable on your specific plan. The goal is keeping you on effective TNF-inhibitor therapy — whatever form that takes.