Auvelity XR can cost $900-$1,300/month without insurance. Learn how to save with coupons, the manufacturer savings card, patient assistance programs, and more.
Auvelity XR is a powerful antidepressant, but its price tag can be a shock. Without insurance, you could pay $900 to $1,300 per month at the pharmacy counter. The good news? There are several ways to pay significantly less — and some patients may even qualify to get it for free.
This guide walks you through every savings option available for Auvelity XR in 2026, from manufacturer coupons to patient assistance programs.
The retail cash price for Auvelity XR varies by pharmacy, but here's what you can expect:
These prices are for the standard 45 mg dextromethorphan / 105 mg bupropion extended-release tablets taken twice daily. Prices vary by pharmacy location and whether you use a discount program.
There is no generic version of Auvelity XR available as of 2026, which is the main reason the price is so high. Without generic competition, brand-name pricing remains at a premium.
This is the single best savings option for most patients. Axsome Therapeutics, the maker of Auvelity XR, offers a savings card that can reduce your out-of-pocket cost to as little as $10 per fill.
If you have commercial insurance, enroll in this program before your first fill. It makes Auvelity XR affordable for most insured patients.
GoodRx offers coupons that can provide savings on Auvelity XR, particularly for patients paying cash (no insurance). While the savings may not be as dramatic as the manufacturer card, GoodRx can still reduce the retail price.
SingleCare works similarly to GoodRx and is accepted at most major pharmacies. It's worth comparing prices between SingleCare and GoodRx to find the best deal at your preferred pharmacy.
Additional coupon and discount platforms to check include:
Note: Discount cards generally cannot be combined with insurance. Use either your insurance + manufacturer savings card, OR a discount card alone — whichever results in a lower out-of-pocket cost.
If you're uninsured, underinsured, or struggling to afford Auvelity XR even with insurance, patient assistance programs (PAPs) can help — sometimes providing the medication at no cost.
Axsome Therapeutics offers a patient assistance program for qualifying patients who cannot afford Auvelity XR.
NeedyMeds is a nonprofit that maintains a database of patient assistance programs, discount drug cards, and other resources. Search for Auvelity XR to find all available programs.
RxAssist provides a comprehensive database of patient assistance programs organized by medication. It includes application information and eligibility requirements.
RxHope helps patients connect with manufacturer assistance programs and can help with the application process.
If your insurance denies coverage or places Auvelity XR on a high-cost tier, ask your doctor to file a prior authorization or appeal. Providing documentation of previous antidepressant failures can often improve coverage. Once approved, your copay may drop significantly.
Prices for the same medication can vary by hundreds of dollars between pharmacies. Use Medfinder or GoodRx to compare prices at pharmacies in your area before filling.
Some insurance plans offer lower copays for 90-day mail-order fills compared to monthly pharmacy pickups. Check with your insurer to see if a mail-order option reduces your per-month cost.
If cost is a barrier even after exploring savings programs, talk to your doctor about whether a lower-cost alternative might work for you. Bupropion (Wellbutrin), one of Auvelity XR's active ingredients, is available as a generic for $10-$30 per month. Learn more in our guide to Auvelity XR alternatives.
Auvelity XR is expensive at retail, but you don't necessarily have to pay full price. Here are your top savings strategies:
Don't let cost keep you from getting the depression treatment you need. Explore the options above, and don't hesitate to ask your doctor or pharmacist for help navigating the process.
More helpful guides:
You focus on staying healthy. We'll handle the rest.
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