How to Help Your Patients Find Eprontia in Stock: A Provider's Guide

When you prescribe Eprontia (Topiramate oral solution, 25 mg/mL) for a patient who needs a liquid anticonvulsant, the last thing you want is for them to call back saying their pharmacy can't fill it. Yet this is a common scenario — and one you can help prevent with the right approach.

This guide covers the current availability landscape, explains why patients struggle to find Eprontia, and gives you five concrete steps to improve your patients' access.

Current Availability

Eprontia is manufactured by Azurity Pharmaceuticals and remains in active production. It is not in a formal FDA shortage. However, practical availability is limited because:

• Most retail pharmacies don't routinely stock it
• It's a brand-name product without a widely available generic liquid equivalent
• Retail pricing ($250–$334 for 120 mL) discourages speculative stocking
• Insurance prior authorization delays reduce fill rates

For a deeper analysis, see our provider briefing: Eprontia Shortage: What Providers Need to Know in 2026.

Why Patients Can't Find Eprontia

Understanding the patient experience helps you anticipate and address problems:

1. The pharmacy doesn't carry it. Patient arrives, pharmacy says "we don't stock that" or "we'd need to order it." Patient feels stuck.
2. Insurance delays. Even if the pharmacy can get it, prior authorization can take days. The patient may give up or go without medication.
3. Cost shock. A patient without adequate coverage learns the price is over $250 and decides not to fill it.
4. Confusion about alternatives. Patient isn't sure if a different Topiramate formulation would work and doesn't want to call the office.

Each of these barriers is addressable at the prescriber level.

What Providers Can Do: 5 Steps

Step 1: Verify Availability Before the Patient Leaves

Use Medfinder for Providers to check which pharmacies near your patient have Eprontia in stock. You can do this during the visit or have your staff check before the patient leaves the office. Sending a prescription to a pharmacy that actually has the medication eliminates the most common barrier.

Step 2: Write a Clear Clinical Justification

On the prescription or prior authorization form, document why the liquid formulation is medically necessary. Common justifications include:

• Patient is a pediatric patient unable to swallow solid oral dosage forms
• Patient has dysphagia or oropharyngeal dysfunction
• Patient uses a nasogastric or gastrostomy tube
• Precise dose titration is required (25 mg/mL allows fine adjustments)
• Patient has a documented history of non-adherence with tablet formulations

A strong clinical justification speeds up prior authorization and may prevent insurance denials.

Step 3: Use "Dispense As Written" (DAW) When Appropriate

If the liquid formulation is clinically necessary, mark the prescription as "Dispense As Written" to prevent the pharmacy from substituting generic Topiramate tablets. This is especially important for patients who physically cannot take tablets.

Step 4: Connect Patients with Cost-Saving Resources

Proactively address the cost barrier:

• Azurity co-pay program: eVoucherRx and Voucher on Demand can reduce out-of-pocket costs for commercially insured patients
• Bridge Program: Azurity provides temporary supply if insurance approval takes more than 48 hours
• Discount coupons: GoodRx and SingleCare can bring the price to $85–$116 for 120 mL
• Patient assistance programs: NeedyMeds and RxAssist for uninsured patients

For a complete cost resource, refer patients to: How to Save Money on Eprontia.

Step 5: Recommend Independent or Specialty Pharmacies

Independent pharmacies are significantly more likely to order and stock specialty medications like Eprontia. If your local chains don't carry it, build a referral relationship with an independent pharmacy that reliably stocks liquid formulations. Compounding pharmacies are also a good resource, though the FDA-approved Eprontia product is generally preferred over compounded alternatives.

Alternatives to Consider

When Eprontia is unavailable or cost-prohibitive, consider these alternatives:

• Generic Topiramate tablets: As low as $2/month; suitable for patients who can swallow pills
• Qudexy XR sprinkle capsules: Can be opened and sprinkled on soft food; once-daily dosing
• Trokendi XR: Once-daily extended-release capsules (must be swallowed whole)
• Topamax sprinkle capsules: 15 mg and 25 mg capsules that can be opened; generic versions available

See our full comparison: Alternatives to Eprontia.

Workflow Tips for Your Practice

Integrating these steps into your clinical workflow doesn't have to be time-consuming:

• Create an Eprontia prescribing checklist for your MA or nurse: check availability → send to stocked pharmacy → document clinical justification → provide cost resources
• Keep a list of pharmacies that stock Eprontia in your area. Update it quarterly using Medfinder.
• Pre-write your PA justification template for liquid Topiramate so it's ready to attach when needed
• Proactively discuss alternatives at the prescribing visit: "If the pharmacy doesn't have the liquid in stock, here's what we can switch to while we wait."
• Set a 7-day follow-up flag for new Eprontia prescriptions to confirm the patient was able to fill it

Final Thoughts

Eprontia is a clinically valuable medication for patients who need liquid Topiramate. The availability challenges are real but manageable with proactive prescribing practices. By verifying stock before sending the prescription, documenting medical necessity clearly, and connecting patients with cost-saving resources, you can significantly reduce the friction your patients face.

Bookmark Medfinder for Providers as your go-to tool for real-time medication availability. And for a broader look at the supply landscape, review our provider briefing on Eprontia availability.