A provider's guide to helping patients afford Duavee. Learn about Pfizer savings programs, discount cards, therapeutic alternatives, and cost conversations.
You've determined that Duavee (Conjugated Estrogens/Bazedoxifene) is the right choice for your patient's moderate-to-severe vasomotor symptoms or osteoporosis prevention. The clinical rationale is solid — a progestin-free approach to endometrial protection that your patient tolerates well.
Then the pharmacy calls: the patient's copay is $200. Or worse, the medication isn't covered at all.
This scenario plays out daily. Duavee is a brand-name medication with no generic equivalent, and its cost — $300–$500 per month at cash price — makes it one of the more expensive hormone therapy options. For many patients, cost becomes the deciding factor in whether they fill the prescription, stay adherent, or abandon treatment altogether.
As a prescriber, you're in a unique position to proactively address cost barriers. This guide walks through the savings programs, discount strategies, and alternative approaches that can help your patients afford their Duavee prescriptions.
Understanding the cost landscape helps you anticipate barriers before they derail treatment:
Without insurance, Duavee costs approximately $300–$500 for a 30-day supply. This price varies by pharmacy but consistently places Duavee among the more expensive HRT options.
Coverage for Duavee is inconsistent across payers:
Even with insurance, out-of-pocket costs can range from $50 to $200+ per month depending on the patient's plan, deductible status, and formulary tier.
Research consistently shows that out-of-pocket costs exceeding $50/month significantly reduce medication adherence, particularly for preventive therapies like osteoporosis prevention where patients may not "feel" an immediate benefit. When patients face unexpected costs at the pharmacy counter, many simply don't fill the prescription — and may not tell you.
Pfizer has offered co-pay assistance programs for Duavee that can significantly reduce out-of-pocket costs for eligible patients:
Provider tip: Mention the savings card at the point of prescribing, not after the patient encounters a high copay. Proactively providing this information prevents the pharmacy sticker shock that leads to abandoned prescriptions.
For uninsured or underinsured patients who meet income eligibility criteria:
Consider having your staff keep application forms on hand or bookmarking the website for quick access during appointments.
For patients who don't qualify for manufacturer programs (or as a supplementary option), several third-party discount platforms may offer savings on Duavee:
Important caveat: Discount card prices for brand-name drugs like Duavee may still be high ($200+), as these cards work best for generics. However, they can provide marginal savings and are worth checking.
For patients who are proactive about cost management, direct them to our comprehensive resource: How to Save Money on Duavee.
When cost is prohibitive despite savings programs, therapeutic substitution becomes a practical conversation. There is no generic equivalent for Duavee as of 2026, but several alternative HRT regimens can achieve similar clinical goals:
An alternative approach is to prescribe conjugated estrogens and a progestin as separate medications, which allows use of individual generics and may offer greater dosing flexibility. However, this adds pill burden and complexity.
Therapeutic substitution isn't always appropriate. Consider maintaining Duavee when:
Document the clinical rationale for Duavee over alternatives — this strengthens prior authorization appeals when needed.
The most effective cost interventions happen proactively, not reactively. Here are workflow strategies that consistently help:
When prior authorization is required, strong clinical documentation improves approval rates:
Cost isn't the only barrier — availability is too. Duavee has experienced intermittent supply disruptions that can delay treatment. Recommend that patients use Medfinder for Providers or direct patients to Medfinder to check pharmacy availability before sending prescriptions.
Duavee offers a clinically meaningful advantage for patients who need progestin-free endometrial protection — but that advantage is worthless if patients can't afford to fill the prescription. By proactively integrating cost conversations, savings program referrals, and therapeutic alternatives into your prescribing workflow, you can help ensure that the right medication reaches the patients who need it.
The tools exist. The savings programs exist. The key is making sure they're part of the conversation before your patient is standing at the pharmacy counter deciding whether to walk away.
For more provider-focused resources on Duavee, see our guides on shortage updates for prescribers and helping patients find Duavee in stock.
You focus on staying healthy. We'll handle the rest.
Try Medfinder Concierge FreeMedfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.
%2C%20Color%3DOriginal.png)
