What Are Your Options If You Can't Get Welchol?

If your pharmacy can't fill your Welchol (Colesevelam) prescription, you may be wondering what alternatives are available. Whether you take Welchol for high cholesterol or type 2 diabetes, there are other medications your doctor may consider.

This guide covers the most common alternatives to Welchol, how they compare, and what to discuss with your doctor.

Important: Never switch medications on your own. Always talk to your doctor before making any changes to your treatment plan.

Why You Might Need an Alternative

There are several reasons you might need a Welchol alternative:

• Your pharmacy is out of stock due to a supply shortage
• The cost is too high, even with insurance
• You're experiencing side effects
• Your doctor wants to try a different approach

Before looking at alternatives, make sure you've tried to find Welchol in stock using tools like MedFinder. The shortage may be temporary or limited to your area.

Alternative #1: Generic Colesevelam

The simplest "alternative" is actually the same medication. Generic Colesevelam contains the identical active ingredient as brand-name Welchol. It's usually cheaper and may be easier to find because multiple manufacturers produce it.

Ask your doctor to update your prescription to allow generic substitution if it currently specifies brand-only Welchol.

Alternative #2: Cholestyramine (Questran)

Cholestyramine is the oldest bile acid sequestrant and works through the same basic mechanism as Welchol. It binds bile acids in the intestine, forcing your liver to use more cholesterol to make new bile acids.

How it compares to Welchol:

• Available as a powder that you mix with water or juice
• Must be taken 1-6 times daily depending on your dose
• Generally more affordable than Welchol
• May cause more GI side effects (bloating, constipation, gas)
• Has more drug interactions — take other medications 1 hour before or 4-6 hours after
• Not FDA-approved for type 2 diabetes

Cholestyramine has been used for decades and has a long safety track record. However, many patients find it harder to tolerate than Welchol due to the taste and GI side effects.

Alternative #3: Colestipol (Colestid)

Colestipol is another bile acid sequestrant available in both tablet and granule (powder) form.

How it compares to Welchol:

• Available as tablets (easier to take) or granules
• Similar effectiveness for lowering LDL cholesterol
• Similar GI side effects to Cholestyramine
• Generally affordable, especially the generic version
• Not FDA-approved for type 2 diabetes

Alternative #4: Ezetimibe (Zetia)

Ezetimibe works differently from Welchol. Instead of binding bile acids, it blocks cholesterol absorption in the small intestine. It's not a bile acid sequestrant, but it's often used as an alternative when patients need non-statin cholesterol lowering.

How it compares to Welchol:

• Taken as a single small tablet once daily
• Fewer GI side effects
• Very affordable as a generic
• Can be combined with statins
• Not approved for type 2 diabetes blood sugar control
• Different mechanism of action

Many doctors consider Ezetimibe a good option for patients who need additional LDL lowering beyond what statins alone provide.

Alternative #5: Statins

If you're not already on a statin and you take Welchol mainly for cholesterol, your doctor may suggest starting a statin instead. Statins like Atorvastatin (Lipitor) or Rosuvastatin (Crestor) are the most widely prescribed cholesterol medications and have strong evidence for preventing heart attacks and strokes.

Statins may be a good option if:

• You haven't tried a statin before
• Your main goal is LDL cholesterol reduction
• You don't have a history of statin intolerance

However, some patients take Welchol specifically because they can't tolerate statins. In that case, the other alternatives above may be better options.

If You Take Welchol for Type 2 Diabetes

Welchol is unique among bile acid sequestrants because it's also FDA-approved to help control blood sugar in type 2 diabetes. If you take Welchol for this reason, your alternatives may be different:

• Your doctor may adjust doses of your other diabetes medications
• Other bile acid sequestrants (Cholestyramine, Colestipol) are not approved for diabetes
• Your doctor may consider adding or adjusting medications like Metformin, SGLT2 inhibitors, or GLP-1 receptor agonists

Talk to your endocrinologist or primary care doctor about the best approach for your specific situation.

Comparing Welchol Alternatives at a Glance

Here's a quick comparison:

• Generic Colesevelam: Same drug, cheaper, may be easier to find
• Cholestyramine: Same class, powder form, more side effects, very affordable
• Colestipol: Same class, tablets or granules, similar profile to Cholestyramine
• Ezetimibe: Different class, once-daily tablet, fewer side effects, very affordable
• Statins: First-line cholesterol therapy, strong evidence base, affordable generics

What to Ask Your Doctor

When discussing alternatives, ask your doctor:

1. Which alternative is best for my specific health needs?
2. Will the alternative interact with my other medications? (See Welchol Drug Interactions)
3. How long should I try the alternative before we reassess?
4. Should we keep trying to find Welchol in the meantime?

You can also use MedFinder to continue checking for Welchol availability while you're on an alternative. For tips on reducing costs, see How to Save Money on Welchol.