Alternatives to Roszet: Your Options in 2026

If you've been taking Roszet (Ezetimibe/Rosuvastatin) and can't fill your prescription, you're dealing with a frustrating reality: Roszet has been discontinued by its manufacturer, Althera Life Sciences. All formulations are off the market, and no generic combination tablet is available.

The good news is that there are several effective alternatives. In this article, we'll explain what Roszet does, how it works, and walk you through the best replacement options so you can keep your cholesterol under control.

What Is Roszet?

Roszet was a combination prescription medication containing two active ingredients:

• Rosuvastatin — a statin that lowers cholesterol production in the liver
• Ezetimibe — a cholesterol absorption inhibitor that blocks cholesterol from being absorbed in the intestines

It was FDA-approved in March 2021 for treating primary hyperlipidemia (high cholesterol) and homozygous familial hypercholesterolemia (HoFH). The main advantage was the convenience of combining two medications into one pill.

For a deeper dive, see our full guide on what Roszet is and how it's used.

How Does Roszet Work?

Your body gets cholesterol from two sources: your liver produces it, and you absorb it from food. Roszet attacks both pathways:

1. Rosuvastatin blocks an enzyme called HMG-CoA reductase in the liver, which reduces the amount of cholesterol your body produces.
2. Ezetimibe works at the brush border of the small intestine to block the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for absorbing cholesterol.

By targeting both production and absorption, this dual approach can lower LDL cholesterol more effectively than either drug alone. Learn more in our article on how Roszet works.

Best Alternatives to Roszet

1. Generic Rosuvastatin + Generic Ezetimibe (Separate Pills)

This is the most direct replacement for Roszet. You take the exact same two active ingredients as separate tablets:

• Generic Rosuvastatin (generic for Crestor) — available in 5 mg, 10 mg, 20 mg, and 40 mg tablets
• Generic Ezetimibe (generic for Zetia) — available as a 10 mg tablet

Cost: About $10 to $30 per month for Rosuvastatin and $10 to $25 per month for Ezetimibe, totaling roughly $20 to $55 per month — significantly less than the $150 to $350 brand Roszet cost.

Pros: Same active ingredients, same doses, widely available, much cheaper
Cons: Two pills instead of one

2. Vytorin (Ezetimibe/Simvastatin)

Vytorin is another combination cholesterol tablet that pairs Ezetimibe with a different statin — Simvastatin instead of Rosuvastatin. Generic versions of Vytorin are available, making it an affordable option.

• Available strengths: Ezetimibe 10 mg / Simvastatin 10 mg, 20 mg, 40 mg, or 80 mg
• Cost: Generic Ezetimibe/Simvastatin costs about $15 to $40 per month

Pros: Single pill, affordable generic available, proven LDL-lowering
Cons: Simvastatin has more drug interactions than Rosuvastatin and may not be as potent at lowering LDL at equivalent doses

3. Atorvastatin + Ezetimibe (Separate Pills)

Another popular combination is Atorvastatin (generic for Lipitor) taken alongside generic Ezetimibe. Atorvastatin is the most widely prescribed statin in the world and is very effective at lowering LDL cholesterol.

• Cost: Generic Atorvastatin costs about $5 to $20 per month; combined with generic Ezetimibe, the total is approximately $15 to $45 per month

Pros: Highly effective, extremely affordable, extensive safety data
Cons: Two pills, slightly different drug interaction profile than Rosuvastatin

4. Rosuvastatin Alone (Higher Dose)

If you were on a lower-dose Roszet, your doctor may consider simply increasing your Rosuvastatin dose instead of adding Ezetimibe. Higher-dose Rosuvastatin (20 mg or 40 mg) can achieve significant LDL reduction on its own.

Pros: Single pill, very affordable generic
Cons: May not lower LDL as much as the two-drug combination, higher statin doses carry slightly increased risk of side effects

How to Switch Safely

Switching from Roszet to an alternative should always be done with your doctor's guidance. Here's what to keep in mind:

• Don't stop your medication abruptly. Contact your doctor as soon as you learn Roszet is unavailable.
• Bring your current prescription info. Your doctor will match the doses of your new medications to what you were taking.
• Get blood work done about 4-8 weeks after switching to make sure your cholesterol levels are staying on target.
• Report any new side effects — especially muscle pain, weakness, or dark urine. See our guide on Roszet side effects for more details.

Final Thoughts

Losing access to Roszet is inconvenient, but it does not have to derail your cholesterol management. The individual generic ingredients are widely available, effective, and much more affordable. Whether you go with separate Rosuvastatin and Ezetimibe, switch to Vytorin's generic, or try another statin combination, you have solid options.

Talk to your doctor, use Medfinder to find the best pharmacy prices, and keep your heart health on track.