Roszet Is a Combination Cholesterol Medication

Roszet is a prescription tablet that combines two cholesterol-lowering drugs — Ezetimibe and Rosuvastatin — into a single pill taken once daily to reduce LDL cholesterol, triglycerides, and other lipids in adults with high cholesterol.

If you've been prescribed Roszet or are researching it for the first time, this guide covers everything you need to know: what it is, how it works, how to take it, who should avoid it, and what it costs in 2026.

What Is Roszet?

Roszet is a brand-name medication manufactured by Althera Life Sciences. It was approved by the FDA in March 2021.

It belongs to the drug class known as antihyperlipidemic combinations, meaning it combines two medications that lower cholesterol through different mechanisms:

• Rosuvastatin — An HMG-CoA reductase inhibitor (commonly called a "statin"). It reduces the amount of cholesterol your liver produces.
• Ezetimibe — A cholesterol absorption inhibitor. It blocks the absorption of cholesterol from food in your small intestine.

By attacking cholesterol from two angles — reducing production and blocking absorption — Roszet can lower LDL more effectively than either drug alone. For a deeper look at how this works, see our article on how Roszet works.

Roszet is not a controlled substance.

Important note: Brand Roszet has been discontinued by the manufacturer. No generic combination product is currently available, though a generic launch is estimated around 2033.

What Is Roszet Used For?

Roszet is FDA-approved for:

• Primary hyperlipidemia — To reduce elevated total cholesterol, LDL cholesterol ("bad" cholesterol), apolipoprotein B (ApoB), non-HDL cholesterol, and triglycerides, and to increase HDL cholesterol ("good" cholesterol) in adults.
• Homozygous familial hypercholesterolemia (HoFH) — A rare genetic condition where the body cannot remove LDL cholesterol from the blood effectively, leading to dangerously high cholesterol levels from a young age.

Doctors may also prescribe the Ezetimibe/Rosuvastatin combination off-label for atherosclerotic cardiovascular disease (ASCVD) risk reduction and mixed dyslipidemia.

How Is Roszet Taken?

Roszet comes in four tablet strengths. All contain Ezetimibe 10 mg combined with different doses of Rosuvastatin:

• Ezetimibe 10 mg / Rosuvastatin 5 mg
• Ezetimibe 10 mg / Rosuvastatin 10 mg
• Ezetimibe 10 mg / Rosuvastatin 20 mg
• Ezetimibe 10 mg / Rosuvastatin 40 mg

Here's how to take it:

• Dose: One tablet once daily. Your doctor chooses the strength based on your cholesterol levels and treatment goals.
• With or without food: Roszet can be taken at any time, with or without a meal.
• Swallow whole: Do not crush, break, chew, or dissolve the tablet.
• Timing with other medications: If you take antacids containing aluminum or magnesium, take them at least 2 hours after Roszet. If you take a bile acid sequestrant like Cholestyramine, take Roszet at least 2 hours before or 4 hours after.

Your doctor will typically start you on a lower dose and adjust based on your lab results after 4 to 12 weeks.

Who Should Not Take Roszet?

Roszet is contraindicated (should not be used) in the following situations:

• Active liver disease or unexplained persistent elevations of liver enzymes (hepatic transaminases)
• Acute liver failure or decompensated cirrhosis
• Pregnancy — Statins can harm a developing fetus
• Breastfeeding
• Known allergy to Rosuvastatin, Ezetimibe, or any inactive ingredient in Roszet

Additionally, caution is needed for:

• Patients of Asian descent (may need lower Rosuvastatin doses due to higher drug exposure)
• Patients with kidney impairment
• Patients with hypothyroidism
• Patients with a history of muscle problems on statins

Always share your full medical history and medication list with your doctor before starting Roszet. Some medications have serious interactions with Roszet, including Cyclosporine and Gemfibrozil.

How Much Does Roszet Cost?

Brand Roszet is expensive — especially since no generic is available for the combination product:

• Cash price: $150 to $350 per 30 tablets, depending on the strength and pharmacy
• Insurance coverage: Many insurers classify Roszet as a non-preferred brand. Prior authorization or step therapy is often required, meaning you may need to try the separate generic components first.
• Generic alternative: Generic Rosuvastatin ($10-$30/month) plus generic Ezetimibe ($10-$25/month) purchased separately costs just $20 to $55 per month — a fraction of the brand price for the same active ingredients.

Since brand Roszet has been discontinued, most patients are better served using the two generic components. For more ways to save, check our guide to Roszet coupons, discounts, and patient assistance.

Final Thoughts

Roszet was designed to simplify cholesterol treatment by combining Ezetimibe and Rosuvastatin into one convenient tablet. While brand Roszet has been discontinued, the medication's active ingredients remain available as separate generics that are widely stocked and much more affordable.

If you're currently taking Roszet and need to refill, check pharmacy availability or talk to your doctor about switching to the individual generics. Either way, the important thing is staying on your cholesterol treatment.

Need to find Roszet? Search Medfinder to check availability at pharmacies near you.