Can't fill your Hadlima prescription? Learn about safe, FDA-approved alternatives including Amjevita, Hyrimoz, Cyltezo, and Humira in this 2026 guide.
If you've been prescribed Hadlima (Adalimumab-bwwd) and your pharmacy can't fill it — or your insurance won't cover it — you're not stuck. There are several FDA-approved alternatives that work the same way and treat the same conditions.
In this guide, we'll explain what Hadlima is, how it works, and walk you through the best alternatives available in 2026. All of these options should be discussed with your doctor before making any changes to your treatment.
Hadlima is a biosimilar to Humira (Adalimumab), one of the most widely prescribed biologic medications in the world. It was FDA-approved in 2019 and launched in the US market in July 2023. Hadlima is made by Organon LLC.
Like Humira, Hadlima is used to treat a wide range of autoimmune and autoinflammatory conditions, including:
For a complete overview, see our article on what Hadlima is, its uses, and dosage.
Hadlima belongs to a class of drugs called TNF (tumor necrosis factor) blockers. TNF-alpha is a protein your immune system produces that causes inflammation. In autoimmune conditions, your body makes too much TNF-alpha, leading to chronic inflammation that damages joints, skin, the digestive tract, and other organs.
Hadlima is a monoclonal antibody — a lab-made protein that binds to TNF-alpha and blocks it from triggering inflammation. By reducing TNF-alpha activity, Hadlima helps control symptoms and can slow disease progression.
It's given as a subcutaneous injection (a shot under the skin), typically every other week. Patients can self-administer at home using a prefilled syringe or the Hadlima PushTouch autoinjector. For more details, read our article on how Hadlima works.
There are several reasons you might need to consider an alternative to Hadlima:
If you're having trouble finding Hadlima specifically, check out our guides on how to find Hadlima in stock and why Hadlima is hard to find before switching.
Humira is the original brand-name Adalimumab, made by AbbVie. It was approved by the FDA in 2002 and has been used by millions of patients worldwide. Hadlima is biosimilar to Humira, so they work identically.
Key facts:
Humira is easier to find at pharmacies since it's been on the market for over 20 years. However, it's much more expensive. AbbVie does offer a savings card program that can bring co-pays down for commercially insured patients. Humira may make sense if you can't access any biosimilar and your insurance covers it without excessive cost-sharing.
Amjevita is an Adalimumab biosimilar made by Amgen. It was one of the first Humira biosimilars to launch in the US in January 2023.
Key facts:
Amjevita has been on the market slightly longer than Hadlima, so some pharmacies and insurance plans may be more familiar with it. It's a solid alternative if Hadlima isn't available on your formulary.
Hyrimoz is an Adalimumab biosimilar made by Sandoz (a division of Novartis). It launched in the US in 2023.
Key facts:
Hyrimoz is another widely available option. Sandoz has extensive experience manufacturing biosimilars, and Hyrimoz has been used in Europe since 2018.
Cyltezo is notable because it was the first Adalimumab biosimilar to receive interchangeable status from the FDA. This means pharmacists in many states can substitute Cyltezo for Humira without needing a new prescription from your doctor (similar to how generic drugs work).
Key facts:
Cyltezo's interchangeable status makes it particularly convenient. If your doctor prescribed Humira but you want a biosimilar, Cyltezo may be the easiest switch.
When deciding which alternative is best for you, consider these factors:
Even though all Adalimumab biosimilars work the same way, you should never switch medications without talking to your doctor first. Your doctor needs to write a new prescription and may want to monitor you after switching to make sure you respond well.
If you're experiencing side effects on Hadlima, that's especially important to discuss. Read our guide on Hadlima side effects to understand what's normal and what needs medical attention.
Not being able to fill your Hadlima prescription is stressful, especially when you depend on it to manage a chronic condition. But you have options. Whether you switch to Amjevita, Hyrimoz, Cyltezo, or even back to Humira, you can continue your TNF blocker therapy without a gap in treatment.
Start by checking insurance coverage and availability using Medfinder, then talk to your doctor about the best path forward. With multiple biosimilars now on the market, you should be able to find an affordable, accessible option that works for you.
You focus on staying healthy. We'll handle the rest.
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