Can't find Amylase/Papain? Explore proven digestive enzyme alternatives including bromelain, pancrelipase, lactase, and more to support your digestion.
If you rely on Amylase/Papain digestive enzyme supplements and can't find them in stock, you're probably feeling stuck. Digestive discomfort doesn't wait for supply chains to sort themselves out. The good news? There are several effective alternatives that can help you manage bloating, gas, and poor digestion while your preferred product is unavailable.
In this guide, we'll explain what Amylase/Papain does, how it works, and walk you through the best alternatives — so you can make an informed choice with your healthcare provider.
Amylase/Papain is a combination of two naturally occurring digestive enzymes found in many over-the-counter supplements:
This combination is popular because it addresses two of the most common digestive bottlenecks — carbohydrate and protein digestion — in a single supplement. Products like NaturesPlus Papaya Enzyme chewable tablets and multi-enzyme capsule blends from brands like Double Wood and Dr. Tobias contain this combination.
For a complete overview, see our article on what Amylase/Papain is and how to use it.
When you eat a meal, your body naturally produces digestive enzymes to break down food. Amylase is produced by your salivary glands and pancreas, while your stomach and small intestine produce various proteases.
Supplemental Amylase/Papain works alongside your body's natural enzymes to enhance digestion. Papain specifically works in a wide pH range, meaning it remains active throughout your digestive tract — from the acidic stomach to the more alkaline small intestine. This makes it particularly effective for people whose natural enzyme production may be low due to aging, stress, or digestive conditions.
For a deeper dive into the science, read our article on how Amylase/Papain works.
Bromelain is a proteolytic enzyme extracted from pineapple stems and juice. Like papain, it breaks down proteins into smaller, more digestible fragments. It also has well-documented anti-inflammatory properties.
Why it's a good alternative:
Things to know: Like papain, bromelain can interact with blood thinners like warfarin. People with pineapple allergy should avoid it. Always check with your doctor before starting bromelain, especially if you take anticoagulant medications.
Pancrelipase is a prescription pancreatic enzyme replacement therapy (PERT) that contains a combination of three enzymes: lipase (for fats), protease (for proteins), and amylase (for carbohydrates). Brand names include Creon, Zenpep, and Pancreaze.
Why it's a good alternative:
Things to know: Pancrelipase requires a prescription. It's derived from porcine (pig) pancreas, which may not be suitable for everyone. The cash price for Creon without insurance ranges from approximately $300 to $900 per month depending on dose, but most insurance plans cover it. Creon also offers a copay card and patient assistance program.
If your digestive issues are primarily related to dairy consumption, lactase may be the right alternative. Lactase is the enzyme that breaks down lactose (milk sugar), and a deficiency in this enzyme causes lactose intolerance.
Why it's a good alternative:
Things to know: Lactase only addresses lactose digestion. If you need broader enzyme support for proteins and starches, you'll want to combine it with other enzymes or choose a multi-enzyme blend.
Alpha-galactosidase, sold under the brand name Beano, is a digestive enzyme that breaks down complex carbohydrates found in beans, vegetables, and whole grains — the foods most likely to cause gas and bloating.
Why it's a good alternative:
Things to know: Beano only addresses carbohydrate-related gas. It does not break down proteins like papain does. For a more complete alternative, consider pairing Beano with a proteolytic enzyme like bromelain.
The best alternative depends on your specific digestive needs:
Always talk to your healthcare provider before switching enzymes, especially if you have a diagnosed condition, are pregnant or breastfeeding, or take blood thinners.
Not being able to find your usual Amylase/Papain supplement is frustrating, but it doesn't mean you have to suffer through digestive discomfort. Bromelain, pancrelipase, lactase, and alpha-galactosidase are all proven alternatives that can help — depending on your specific needs.
Before switching, check Medfinder to see if Amylase/Papain is available near you. And for more information on side effects and drug interactions with any enzyme supplement, read our guide on Amylase/Papain drug interactions.
You focus on staying healthy. We'll handle the rest.
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