Alora has been discontinued. Here are the best alternatives to Alora, including other estradiol patches, gels, sprays, and oral options for menopausal hormone therapy.
If you've just learned that Alora is no longer available, it's natural to feel frustrated or worried. You relied on this medication, and now it's gone. The good news: the active ingredient in Alora — estradiol — is available in many other forms. You and your doctor can find a replacement that works just as well.
This guide walks through every major alternative, so you can have an informed conversation with your healthcare provider about what's right for you.
Alora was a twice-weekly estradiol transdermal patch that delivered 0.025 mg, 0.05 mg, 0.075 mg, or 0.1 mg of estradiol per day through the skin. It was used to treat menopausal symptoms like hot flashes, night sweats, and vaginal dryness, as well as to prevent osteoporosis.
Any replacement should deliver a similar dose of estradiol. The main differences between alternatives come down to how the estradiol is delivered (patch vs. gel vs. pill), how often you use it, and the cost.
These are the most direct substitutes for Alora because they deliver estradiol the same way — through the skin via a patch.
Best for: Most patients switching from Alora
Best for: Patients who want a small, discreet patch
Best for: Patients who want to change their patch less often
Best for: Patients looking for a small-sized patch option
Best for: Patients looking for newer brand options
If estradiol patches are hard to find across the board, your doctor may recommend a different way to get your estradiol.
Divigel, EstroGel
Evamist
Estrace (estradiol oral tablets)
If your main symptom is vaginal dryness or urinary symptoms (not hot flashes), localized vaginal estradiol may be appropriate:
Note: Femring delivers systemic estradiol levels similar to patches and can treat hot flashes. The other vaginal products are primarily for local symptoms.
If you take a progestin along with your estrogen (as most women with a uterus should), there are combination options:
When you talk to your prescriber about switching from Alora, here's what to discuss:
Here's a rough comparison of monthly costs for estradiol alternatives (with discount coupons, no insurance):
For help finding the best price, see our guide: How to save money on Alora in 2026: Coupons, discounts, and patient assistance.
Losing access to Alora is inconvenient, but it's not a dead end. The active ingredient — estradiol — is widely available in multiple forms. Generic estradiol patches are the closest substitute, but gels, sprays, and oral tablets offer good alternatives if patches are hard to find.
Talk to your doctor, use Medfinder to check availability in your area, and don't go without your medication. You have options.
Related reading:
You focus on staying healthy. We'll handle the rest.
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