Alternatives to Abrilada if You Can't Fill Your Prescription

If you've been prescribed Abrilada (Adalimumab-afzb) but can't get it filled — whether because of insurance restrictions, availability issues, or cost — you're not stuck. There are several FDA-approved alternatives that work the same way and treat the same conditions.

In this guide, we'll explain what Abrilada is, how it works, and walk you through your best alternative options so you can keep your treatment on track.

What Is Abrilada?

Abrilada is a TNF alfa inhibitor — a type of biologic medication that reduces inflammation by blocking a protein called tumor necrosis factor alpha (TNF-α). It's made by Pfizer and is an interchangeable biosimilar to Humira (Adalimumab), which means it has been shown to produce the same clinical results as Humira.

Abrilada is FDA-approved to treat nine autoimmune conditions:

• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis
• Ankylosing spondylitis
• Crohn's disease (adults and children 6+)
• Ulcerative colitis
• Plaque psoriasis (moderate to severe)
• Hidradenitis suppurativa
• Juvenile idiopathic arthritis (children 2+)
• Non-infectious uveitis in adults

To learn more about this medication, visit our comprehensive guide on what Abrilada is, its uses, and dosage.

How Does Abrilada Work?

In autoimmune conditions, your immune system mistakenly attacks healthy tissues, causing chronic inflammation. TNF-α is one of the key proteins that drives this inflammatory response.

Abrilada works by binding to TNF-α and preventing it from triggering inflammation. This helps reduce symptoms like joint pain, skin lesions, digestive issues, and other problems caused by overactive immune responses. For a deeper dive, read our article on how Abrilada works.

Why You Might Need an Alternative

There are several common reasons patients look for alternatives to Abrilada:

• Insurance doesn't cover it. Your plan's formulary may prefer a different adalimumab biosimilar.
• Prior authorization was denied. Your insurer may require step therapy with another product first.
• Availability issues. Your specialty pharmacy may not stock Abrilada or may have temporary supply delays.
• Cost concerns. Even with insurance, specialty copays can be high, and another biosimilar may offer better savings programs.

Whatever the reason, the good news is that all adalimumab biosimilars with interchangeable status are clinically equivalent to Humira — and to each other. Switching between them is safe and effective.

Best Alternatives to Abrilada

1. Amjevita (Adalimumab-atto)

Manufacturer: Amgen

Status: FDA-approved interchangeable biosimilar to Humira

Amjevita was one of the first adalimumab biosimilars to enter the U.S. market. It's available in both a standard-priced version and a low-cost version that is priced approximately 55% below Humira's list price. Amjevita is widely available through major specialty pharmacies and is on many insurance formularies as a preferred biosimilar.

Available forms: Prefilled syringe (10 mg, 20 mg, 40 mg) and autoinjector pen (40 mg)

2. Cyltezo (Adalimumab-adbm)

Manufacturer: Boehringer Ingelheim

Status: FDA-approved interchangeable biosimilar to Humira

Cyltezo was the first adalimumab biosimilar to receive interchangeable status from the FDA. It launched in the U.S. in July 2023 and is available at a significant discount to Humira. Cyltezo is carried by several large specialty pharmacy networks, and many PBMs include it as a preferred product.

Available forms: Prefilled syringe (40 mg) and autoinjector pen (40 mg)

3. Hadlima (Adalimumab-bwwd)

Manufacturer: Samsung Bioepis / Organon

Status: FDA-approved interchangeable biosimilar to Humira

Hadlima offers one of the lowest wholesale acquisition costs among adalimumab biosimilars — approximately 85% below Humira's list price. This makes it an attractive option for patients and health plans looking for maximum savings. It's increasingly available through specialty pharmacies and is preferred on several major formularies.

Available forms: Prefilled syringe (40 mg) and autoinjector pen (40 mg)

4. Hyrimoz (Adalimumab-adaz)

Manufacturer: Sandoz

Status: FDA-approved interchangeable biosimilar to Humira

Hyrimoz is another well-established adalimumab biosimilar with a citrate-free formulation designed to reduce injection-site discomfort — similar to Abrilada. It's available at competitive pricing and is carried by many specialty pharmacies. Sandoz, a division of Novartis, has a strong track record in the biosimilar space.

Available forms: Prefilled syringe (20 mg, 40 mg) and autoinjector pen (40 mg)

How to Switch to an Alternative

Switching between adalimumab biosimilars is straightforward because they all contain the same active ingredient and are administered the same way. Here's what to do:

1. Talk to your doctor. Let your prescriber know that Abrilada isn't available or isn't covered. They can write a new prescription for an alternative biosimilar.
2. Check your insurance formulary. Ask your insurer which adalimumab product is preferred on your plan. This will be the easiest and most affordable option.
3. Use Medfinder. Visit medfinder.com to check which adalimumab biosimilars are available at pharmacies near you.
4. Enroll in a savings program. Each biosimilar manufacturer offers its own co-pay assistance or savings program. Ask your new specialty pharmacy about available discounts.

What About Humira?

You can also switch to brand-name Humira (Adalimumab), though it's typically the most expensive option. Humira's list price is significantly higher than its biosimilars. However, AbbVie does offer a robust savings program that can reduce copays for commercially insured patients. If your insurance prefers Humira, it may still be a viable option.

Final Thoughts

If you can't fill your Abrilada prescription, don't delay your treatment. Multiple interchangeable adalimumab biosimilars are available, and your doctor can help you switch safely. Use Medfinder to check availability, talk to your insurer about preferred products, and explore savings programs.

For more information, read our guides on how to find Abrilada in stock and how to save money on Abrilada.