Comprehensive medication guide to Xulane including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$30 copay under most plans; covered with no cost-sharing under the ACA contraceptive mandate.
Estimated Cash Pricing
$100–$200 retail per month; as low as $47–$77 with GoodRx or SingleCare coupons.
Medfinder Findability Score
60/100
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Xulane is a prescription transdermal contraceptive patch used to prevent pregnancy. It contains two hormones — Norelgestromin (a progestin) and Ethinyl Estradiol (an estrogen) — that are absorbed through the skin over the course of a week. Xulane is a generic version of the discontinued brand Ortho Evra and is manufactured by Mylan Pharmaceuticals (a Viatris company). It is approved for use in women with a BMI under 30 kg/m².
Xulane works by delivering a steady dose of Norelgestromin and Ethinyl Estradiol through the skin into the bloodstream. These hormones prevent pregnancy in three ways: they so no egg is released, to block sperm from reaching the uterus, and to reduce the chance of implantation. You apply one patch per week for three weeks, then take one patch-free week during which withdrawal bleeding occurs.
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Transdermal patch — patch
delivers 150 mcg/day Norelgestromin and 35 mcg/day Ethinyl Estradiol
Xulane scores a 60 out of 100 on our findability scale, meaning it may require some effort to locate. While Xulane is not currently listed on the FDA drug shortage database, intermittent supply disruptions have been reported at individual pharmacies. As a branded generic transdermal patch with a niche delivery method, not every pharmacy keeps it consistently stocked. If your local pharmacy is out, try calling nearby chains or use Medfinder to check availability in your area.
Xulane can be prescribed by a wide range of healthcare providers, including OB/GYNs, Family Medicine doctors, Internal Medicine physicians, Adolescent Medicine specialists, Nurse Practitioners, and Physician Assistants. Telehealth services also commonly prescribe Xulane, making it convenient to get a prescription without an in-person visit.
No. Xulane is not a controlled substance and has no DEA scheduling. It is a standard prescription medication that does not require special handling or refill restrictions beyond a valid prescription.
Serious side effects can include blood clots (deep vein thrombosis, pulmonary embolism), stroke, heart attack, liver tumors, and gallbladder disease. Xulane carries a boxed warning about increased cardiovascular risk in smokers over 35 and is contraindicated in women with a BMI ≥ 30 kg/m².
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Twirla
A brand-name contraceptive patch with a lower hormone dose (Levonorgestrel/Ethinyl Estradiol), applied weekly.
Zafemy
Another generic Norelgestromin/Ethinyl Estradiol patch, slightly smaller than Xulane.
NuvaRing
A vaginal ring (Etonogestrel/Ethinyl Estradiol) inserted once monthly for non-daily contraception.
Combined oral contraceptive pills
Daily estrogen/progestin pills available in many brands including Yaz, Lo Loestrin Fe, and numerous generics.
Prefer Xulane? We can find it.
Hepatitis C drugs
moderate(Ombitasvir/Paritaprevir/Ritonavir) — contraindicated due to risk of ALT elevations
Enzyme inducers
moderate(Rifampin, Carbamazepine, Phenytoin, Phenobarbital, Topiramate) — decrease contraceptive effectiveness
St. John's Wort
moderatereduces Xulane's effectiveness
HIV protease inhibitors and NNRTIs
moderatemay alter hormone levels
Lamotrigine
moderateXulane decreases Lamotrigine levels, potentially increasing seizure risk
Antibiotics
moderate(Ampicillin, Tetracyclines) — may theoretically reduce effectiveness
Xulane is a convenient weekly contraceptive patch that eliminates the need to remember a daily pill. While it is generally available, some patients may encounter intermittent stock issues at their local pharmacy. With discount cards, cash prices can drop to under $50 per month, and most insured patients pay little to nothing under the ACA contraceptive mandate. If you're having trouble finding Xulane in stock, use Medfinder to search pharmacies near you.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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