Medications

Xulane

Xulane

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$0–$30 copay under most plans; covered with no cost-sharing under the ACA contraceptive mandate.
Estimated Cash Pricing
$100–$200 retail per month; as low as $47–$77 with GoodRx or SingleCare coupons.
Medfinder Findability Score
60
/100
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Post Author

Peter Daggett

Last Updated

February 17, 2026

Xulane 2026 Availability, Prices, and Tips to Find

What Is Xulane?

Xulane is a prescription transdermal contraceptive patch used to prevent pregnancy. It contains two hormones — Norelgestromin (a progestin) and Ethinyl Estradiol (an estrogen) — that are absorbed through the skin over the course of a week. Xulane is a generic version of the discontinued brand Ortho Evra and is manufactured by Mylan Pharmaceuticals (a Viatris company). It is approved for use in women with a BMI under 30 kg/m².

How does Xulane work?

Xulane works by delivering a steady dose of Norelgestromin and Ethinyl Estradiol through the skin into the bloodstream. These hormones prevent pregnancy in three ways: they suppress ovulation so no egg is released, thicken cervical mucus to block sperm from reaching the uterus, and thin the uterine lining to reduce the chance of implantation. You apply one patch per week for three weeks, then take one patch-free week during which withdrawal bleeding occurs.

What doses are available for Xulane?

  • Transdermal patch — delivers 150 mcg/day Norelgestromin and 35 mcg/day Ethinyl Estradiol

Xulane is available in a single strength. Each box contains 3 patches for a 28-day cycle (3 weeks on, 1 week off).

How hard is it to find Xulane in stock?

Xulane scores a 60 out of 100 on our findability scale, meaning it may require some effort to locate. While Xulane is not currently listed on the FDA drug shortage database, intermittent supply disruptions have been reported at individual pharmacies. As a branded generic transdermal patch with a niche delivery method, not every pharmacy keeps it consistently stocked. If your local pharmacy is out, try calling nearby chains or use Medfinder to check availability in your area.

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Who Can Prescribe Xulane?

Xulane can be prescribed by a wide range of healthcare providers, including OB/GYNs, Family Medicine doctors, Internal Medicine physicians, Adolescent Medicine specialists, Nurse Practitioners, and Physician Assistants. Telehealth services also commonly prescribe Xulane, making it convenient to get a prescription without an in-person visit.

Is Xulane a controlled substance?

No. Xulane is not a controlled substance and has no DEA scheduling. It is a standard prescription medication that does not require special handling or refill restrictions beyond a valid prescription.

Common Side Effects of Xulane

  • Application site reaction or skin irritation
  • Nausea
  • Headache
  • Breast tenderness or pain
  • Mood changes
  • Menstrual cramps
  • Abdominal pain
  • Weight gain

Serious side effects can include blood clots (deep vein thrombosis, pulmonary embolism), stroke, heart attack, liver tumors, and gallbladder disease. Xulane carries a boxed warning about increased cardiovascular risk in smokers over 35 and is contraindicated in women with a BMI ≥ 30 kg/m².

Alternative Medications to Xulane

  • Twirla — A brand-name contraceptive patch with a lower hormone dose (Levonorgestrel/Ethinyl Estradiol), applied weekly.
  • Zafemy — Another generic Norelgestromin/Ethinyl Estradiol patch, slightly smaller than Xulane.
  • NuvaRing — A vaginal ring (Etonogestrel/Ethinyl Estradiol) inserted once monthly for non-daily contraception.
  • Combined oral contraceptive pills — Daily estrogen/progestin pills available in many brands including Yaz, Lo Loestrin Fe, and numerous generics.

Drug Interactions with Xulane

  • Hepatitis C drugs (Ombitasvir/Paritaprevir/Ritonavir) — contraindicated due to risk of ALT elevations
  • Enzyme inducers (Rifampin, Carbamazepine, Phenytoin, Phenobarbital, Topiramate) — decrease contraceptive effectiveness
  • St. John's Wort — reduces Xulane's effectiveness
  • HIV protease inhibitors and NNRTIs — may alter hormone levels
  • Lamotrigine — Xulane decreases Lamotrigine levels, potentially increasing seizure risk
  • Antibiotics (Ampicillin, Tetracyclines) — may theoretically reduce effectiveness

Always inform your healthcare provider about all medications and supplements you are taking before starting Xulane.

Final Thoughts on Xulane

Xulane is a convenient weekly contraceptive patch that eliminates the need to remember a daily pill. While it is generally available, some patients may encounter intermittent stock issues at their local pharmacy. With discount cards, cash prices can drop to under $50 per month, and most insured patients pay little to nothing under the ACA contraceptive mandate. If you're having trouble finding Xulane in stock, use Medfinder to search pharmacies near you.

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