Comprehensive medication guide to Semglee including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Most insured patients pay $0–$35 per prescription with the Semglee savings card, or a standard formulary copay of $25–$75.
Estimated Cash Pricing
Semglee typically costs $125–$350 per pen pack or vial without insurance, though discount cards can bring it down to $80–$150.
Medfinder Findability Score
65/100
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Semglee (Insulin Glargine-yfgn) is a long-acting basal insulin analog manufactured by Mylan (Viatris). It is an interchangeable biosimilar to Lantus, meaning it can be substituted at the pharmacy without requiring a new prescription from your doctor. Semglee is FDA-approved to improve blood sugar control in adults and children (ages 6 and older) with Type 1 diabetes and adults with Type 2 diabetes. It provides steady insulin coverage for approximately 24 hours with once-daily dosing.
Semglee contains Insulin Glargine-yfgn, which forms tiny microprecipitates when injected under the skin. These microprecipitates dissolve slowly, providing a steady, prolonged release of insulin over approximately 24 hours. The insulin works by helping cells in your muscles and fat tissue absorb glucose from the bloodstream, while also reducing the amount of glucose your liver produces. This basal (background) insulin coverage helps maintain stable blood sugar levels between meals and overnight.
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![How to Find a Doctor Who Can Prescribe Semglee Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F5db629701b7e7320b385d7114cbde44f8787698a-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Semglee Pre-Filled Pen
100 units/mL in a 3 mL pen (box of 5 pens)
Semglee Vial
100 units/mL in a 10 mL vial
Semglee has experienced intermittent supply disruptions since 2023, with some pharmacies reporting limited availability of certain pen presentations. As a biosimilar insulin glargine product, availability can vary regionally. We rate Semglee's findability at 65 out of 100, meaning you may encounter occasional stock issues depending on your area and preferred formulation. Calling ahead to your pharmacy or checking multiple locations is recommended.
Semglee can be prescribed by a range of healthcare providers, including:
Telehealth consultations are also available for insulin management in many states.
No, Semglee is not a controlled substance. It is not scheduled by the DEA. However, insulin is a prescription medication and must be prescribed by a licensed healthcare provider. In some states, insulin may be available without a prescription in emergency situations, but this varies by state law.
Serious side effects include severe hypoglycemia (confusion, seizures, loss of consciousness), hypokalemia (low potassium), and increased risk of heart failure when used with thiazolidinediones.
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Lantus
Brand-name Insulin Glargine (100 units/mL) by Sanofi, the reference product for Semglee
Basaglar
Follow-on Insulin Glargine (100 units/mL) by Eli Lilly, another biosimilar to Lantus
Levemir
Insulin Detemir, a different long-acting basal insulin by Novo Nordisk
Toujeo
Insulin Glargine 300 units/mL (concentrated) by Sanofi, offering longer duration and potentially less hypoglycemia risk
Prefer Semglee? We can find it.
Other diabetes medications
moderate(sulfonylureas, Metformin, GLP-1 agonists) — increased risk of hypoglycemia
Beta-blockers
moderatemay mask symptoms of low blood sugar
ACE inhibitors and ARBs
moderatemay increase insulin sensitivity
Thiazolidinediones
moderate(Pioglitazone, Rosiglitazone) — increased risk of heart failure and edema
Corticosteroids
moderatemay decrease insulin effectiveness, raising blood sugar
Sympathomimetics
moderate(epinephrine, Albuterol) — may raise blood glucose
Alcohol
moderatecan increase the risk of hypoglycemia
Semglee is an important and more affordable option for patients who need long-acting basal insulin. As the first interchangeable biosimilar to Lantus, it offers the same clinical effectiveness at a lower price point — with cash prices as low as $80–$150 using discount cards, and copays as low as $0–$35 with the manufacturer savings card. While intermittent supply issues mean it scores a 65 on our findability scale, most patients can locate it by checking multiple pharmacies or asking their pharmacist to order it. If you're struggling to find Semglee, consider alternatives like Basaglar or Lantus, and ask your doctor about the Viatris Patient Assistance Program if cost is a barrier.
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