Medications

Roszet

Roszet

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$30–$75 copay if covered; many plans require prior authorization or step therapy with generic components first.
Estimated Cash Pricing
$150–$350 per month for brand Roszet; taking generic Rosuvastatin + generic Ezetimibe separately costs just $20–$55/month.
Medfinder Findability Score
55
/100
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Post Author

Peter Daggett

Last Updated

February 16, 2026

Roszet 2026 Availability, Prices, and Tips to Find

What Is Roszet?

Roszet is a combination prescription medication containing Ezetimibe and Rosuvastatin in a single tablet. It is used to treat primary hyperlipidemia (high cholesterol) and homozygous familial hypercholesterolemia (HoFH). Roszet works by reducing LDL ("bad") cholesterol, total cholesterol, triglycerides, and ApoB while increasing HDL ("good") cholesterol.

Roszet was FDA-approved in March 2021 and manufactured by Althera Life Sciences. The brand has since been discontinued, but the same active ingredients are available separately as generic Rosuvastatin (formerly Crestor) and generic Ezetimibe (formerly Zetia).

How does Roszet work?

Roszet combines two cholesterol-lowering medications with complementary mechanisms of action:

  • Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that blocks cholesterol production in the liver, reducing the amount of cholesterol your body makes.
  • Ezetimibe is a cholesterol absorption inhibitor that blocks the absorption of dietary and biliary cholesterol at the brush border of the small intestine.

By targeting both cholesterol production and absorption simultaneously, Roszet can lower LDL cholesterol more effectively than either medication alone.

What doses are available for Roszet?

  • Ezetimibe 10 mg / Rosuvastatin 5 mg tablet
  • Ezetimibe 10 mg / Rosuvastatin 10 mg tablet
  • Ezetimibe 10 mg / Rosuvastatin 20 mg tablet
  • Ezetimibe 10 mg / Rosuvastatin 40 mg tablet

All strengths contain 10 mg of Ezetimibe combined with varying doses of Rosuvastatin. Your doctor will determine the appropriate strength based on your cholesterol levels and treatment goals.

How hard is it to find Roszet in stock?

Roszet has a findability score of 55 out of 100, meaning it can be difficult to locate. The brand has been discontinued by the manufacturer (Althera Life Sciences) as of 2025, making it essentially unavailable at most pharmacies. While remaining stock may exist at some locations, supply is not being replenished. Most patients are now being switched to the individual generic components — generic Rosuvastatin and generic Ezetimibe — which are widely available and significantly cheaper.

Use Medfinder to check pharmacy availability near you, or talk to your doctor about switching to the separate generic components.

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Who Can Prescribe Roszet?

Roszet can be prescribed by a range of healthcare providers, including:

  • Cardiologists — heart and cardiovascular disease specialists
  • Internal Medicine physicians
  • Family Medicine doctors
  • Endocrinologists — specialists in metabolic and hormonal conditions
  • Primary Care providers (MDs, DOs, NPs, PAs)

Telehealth consultations are also available for cholesterol management. Use Medfinder to find providers who can prescribe Roszet or its alternatives near you.

Is Roszet a controlled substance?

No, Roszet is not a controlled substance. It is not classified under any DEA schedule. It is a standard prescription medication that does not have abuse or dependence potential. You can receive Roszet prescriptions via telehealth, mail-order pharmacies, and standard refill processes without the restrictions that apply to controlled substances.

Common Side Effects of Roszet

  • Headache
  • Myalgia (muscle pain)
  • Arthralgia (joint pain)
  • Nausea
  • Dizziness
  • Constipation
  • Abdominal pain
  • Weakness or fatigue
  • Upper respiratory tract infection
  • Diarrhea

Serious side effects (seek medical attention immediately):

  • Rhabdomyolysis — severe muscle breakdown that can damage the kidneys
  • Immune-mediated necrotizing myopathy (IMNM)
  • Liver injury (hepatotoxicity)
  • Pancreatitis
  • Severe allergic reactions (angioedema, anaphylaxis)

Contact your doctor if you experience unexplained muscle pain, tenderness, or weakness, especially with fever or dark urine.

Alternative Medications to Roszet

Since Roszet has been discontinued, your doctor will likely recommend one of these alternatives:

  • Generic Rosuvastatin + Generic Ezetimibe — the same active ingredients taken as two separate pills; costs $20–$55/month total
  • Vytorin (Ezetimibe/Simvastatin) — a similar combination tablet using a different statin
  • Crestor (Rosuvastatin) + Zetia (Ezetimibe) — brand-name versions taken separately
  • Lipitor (Atorvastatin) + Zetia (Ezetimibe) — a commonly prescribed combination using a different statin

Talk to your doctor about which alternative best fits your cholesterol management plan.

Drug Interactions with Roszet

Do not take Roszet with:

  • Cyclosporine — increases Rosuvastatin levels up to 7-fold
  • Gemfibrozil — significantly increases statin exposure and myopathy risk

Use caution with:

  • Other fibrates (Fenofibrate, Bezafibrate) — increased myopathy risk
  • Niacin at doses ≥1 g/day — increased myopathy risk
  • Colchicine — increased myopathy risk
  • Warfarin and other anticoagulants — may increase INR and bleeding risk
  • Certain HIV antivirals (Atazanavir, Darunavir, Ritonavir) — dose adjustments needed
  • Bile acid sequestrants (Cholestyramine, Colesevelam) — take at least 2–4 hours apart

Always tell your doctor about all medications you are taking, including over-the-counter drugs and supplements.

Final Thoughts on Roszet

Roszet was a convenient single-tablet option for patients who needed both Ezetimibe and Rosuvastatin to manage their cholesterol. However, since the brand has been discontinued by the manufacturer, most patients will need to switch to the individual generic components — which are widely available and much more affordable at $20–$55/month combined.

If you're still looking for Roszet or need help finding an alternative, use Medfinder to search pharmacies near you or speak with your doctor about the best option for your cholesterol management.

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