Medications

Relexxii

Relexxii

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$10-$50 copay; may require prior authorization for brand
Estimated Cash Pricing
$200-$355 retail; as low as $39-$70 with GoodRx or SingleCare coupons
Medfinder Findability Score
55
/100
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Post Author

Peter Daggett

Last Updated

February 17, 2026

Relexxii 2026 Availability, Prices, and Tips to Find

What Is Relexxii?

Relexxii is a brand-name, once-daily, extended-release form of Methylphenidate Hydrochloride. It is FDA-approved to treat ADHD in adults (up to age 65) and children ages 6 and older. Made by Vertical Pharmaceuticals (an Osmotica subsidiary), it uses osmotic (OROS) delivery technology to release medication at a controlled rate throughout the day.

How does Relexxii work?

Relexxii blocks the reuptake of dopamine and norepinephrine in the brain, increasing the availability of these neurotransmitters. Its osmotic delivery system uses a semipermeable membrane and bilayer core to push methylphenidate through a laser-drilled opening at a steady rate over 6-7 hours, providing smooth, all-day symptom control.

What doses are available for Relexxii?

  • 18 mg extended-release tablet
  • 27 mg extended-release tablet
  • 36 mg extended-release tablet
  • 45 mg extended-release tablet
  • 54 mg extended-release tablet
  • 63 mg extended-release tablet
  • 72 mg extended-release tablet

How hard is it to find Relexxii in stock?

Relexxii is a newer brand-name ADHD medication that many pharmacies don't routinely stock. Combined with the ongoing methylphenidate shortage, patients often need to call multiple pharmacies or use tools like Medfinder to locate it. Supply is improving as DEA quotas increase but remains inconsistent.

Thanks to a partnership between Relexxii's manufacturer and Medfinder, patients can access our medication locating services completely free of charge.
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Who Can Prescribe Relexxii?

Psychiatrists, primary care physicians, pediatricians, neurologists, and qualified nurse practitioners or physician assistants with DEA registration can prescribe Relexxii. As a Schedule II controlled substance, it requires a written or e-prescribed prescription that cannot be called in or transferred between pharmacies.

Is Relexxii a controlled substance?

Yes. Relexxii is a DEA Schedule II controlled substance due to its potential for abuse and dependence. It carries a boxed warning about abuse risk. Manufacturing is limited by annual DEA production quotas, which has contributed to supply constraints.

Common Side Effects of Relexxii

  • Decreased appetite
  • Headache
  • Dry mouth
  • Nausea
  • Insomnia
  • Anxiety
  • Dizziness
  • Weight loss
  • Irritability

Alternative Medications to Relexxii

  • Concerta — Same OROS osmotic delivery; bioequivalent to Relexxii
  • Aptensio XR — Methylphenidate ER capsule that can be opened and sprinkled
  • Jornay PM — Methylphenidate ER taken at night, active by morning
  • Vyvanse (Lisdexamfetamine) — Different stimulant class; amphetamine-based alternative

Drug Interactions with Relexxii

  • MAO inhibitors — Risk of hypertensive crisis; do not use within 14 days
  • Halogenated anesthetics — Risk of sudden BP/HR increase during surgery
  • SSRIs and serotonergic drugs — Risk of serotonin syndrome
  • Anticoagulants, anticonvulsants, TCAs — May be potentiated
  • Antihypertensives — Effectiveness may be reduced
  • Alcohol — May alter release profile; avoid

Final Thoughts on Relexxii

Relexxii offers a once-daily ADHD treatment option using proven osmotic delivery technology at a lower cash price than Concerta. While pharmacy availability can be challenging due to the ongoing stimulant shortage, tools like Medfinder can help you locate it in stock near you.

The manufacturer of Relexxii has partnered with Medfinder to provide medication locating services free of charge. Visit medfinder.com to find Relexxii in stock near you at no cost.

Through our partnership with Relexxii's manufacturer, Medfinder provides complimentary medication locating services to help patients find Relexxii when they need it most.

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