Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Quviviq (Daridorexant) is a prescription medication approved by the FDA for the treatment of insomnia in adults who have difficulty falling asleep and/or staying asleep. It belongs to a class of drugs called dual orexin receptor antagonists (DORAs). Quviviq is manufactured by Idorsia Pharmaceuticals and is available as an oral tablet in 25 mg and 50 mg strengths. It is taken once nightly, within 30 minutes of going to bed, with at least 7 hours remaining before your planned wake-up time.
Quviviq works by blocking the orexin receptors (OX1 and OX2) in the brain. Orexin is a neuropeptide that promotes wakefulness. By blocking these receptors, Quviviq reduces the brain's drive to stay awake, allowing a more natural transition into sleep. Unlike older sleep medications such as benzodiazepines or Z-drugs (like Ambien), Quviviq does not interact with GABA receptors, which may result in a different side effect profile and lower risk of dependence.
The recommended dose is 25 mg or 50 mg taken once nightly within 30 minutes of bedtime. Patients taking moderate CYP3A4 inhibitors should not exceed 25 mg.
Quviviq scores a 55 out of 100 on our findability scale, meaning it can be moderately difficult to locate in stock. As a newer brand-name medication manufactured by Idorsia Pharmaceuticals, not all pharmacies routinely stock it. Chain pharmacies may not carry Quviviq regularly, and you may need to call around or check with specialty pharmacies. While Quviviq is not listed on the FDA Drug Shortage Database, its limited availability at some locations means patients should plan ahead when filling prescriptions.
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Quviviq can be prescribed by a range of healthcare providers, including sleep medicine specialists, psychiatrists, neurologists, primary care physicians, and internal medicine doctors. Telehealth consultations are also available for Quviviq prescriptions in many cases. If you are struggling with insomnia, your primary care doctor is often a good starting point, though they may refer you to a sleep specialist for further evaluation.
Yes, Quviviq is classified as a Schedule IV controlled substance by the DEA. This means it has a recognized medical use but carries some potential for abuse and dependence, though the risk is considered lower than Schedule II or III substances. As a controlled substance, Quviviq prescriptions may have refill limitations and require proper identification at the pharmacy.
Serious but less common side effects include complex sleep behaviors (such as sleepwalking or sleep-driving), sleep paralysis, hallucinations, temporary leg weakness, and worsening of depression or suicidal ideation. Contact your healthcare provider immediately if you experience any of these serious side effects.
Quviviq represents a newer approach to treating insomnia by targeting the orexin system rather than the GABA pathway used by older sleep medications. While it can be moderately difficult to find in stock and carries a higher price tag ($550–$680 per month without insurance), the QUVIVIQ360 savings program can significantly reduce costs for eligible commercially insured patients. No generic version is currently available, with patents extending through 2034. If you're having trouble locating Quviviq at your local pharmacy, Medfinder can help you search for pharmacies that have it in stock near you.
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