Comprehensive medication guide to Ortho Tri-Cyclen 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay under most plans per ACA contraceptive mandate; some plans may require a preferred generic.
Estimated Cash Pricing
$13–$55 per pack for generics; as low as $6–$25 with GoodRx or SingleCare discount cards.
Medfinder Findability Score
85/100
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Ortho Tri-Cyclen 28 Day is a triphasic combination oral contraceptive containing norgestimate (a progestin) and ethinyl estradiol (an estrogen). It is FDA-approved for the prevention of pregnancy and for the treatment of moderate acne vulgaris in females at least 15 years old who have reached menarche. As a triphasic pill, the dose of norgestimate increases in three phases over the 21-day active cycle, while the estrogen dose stays constant. The pack includes 21 active tablets and 7 placebo tablets for a complete 28-day cycle. While the brand name was discontinued by Janssen, identical generic versions like Tri-Sprintec and Tri-Estarylla are widely prescribed today.
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Ortho Tri-Cyclen 28 Day works through three primary mechanisms to prevent pregnancy: (1) It inhibits ovulation by suppressing the hormonal signals (FSH and LH) needed for egg release. (2) It thickens cervical mucus, making it harder for sperm to reach the egg. (3) It alters the uterine lining (endometrium), reducing the likelihood of implantation. The triphasic design gradually increases the progestin dose across three 7-day phases, which is designed to more closely mimic the body's natural hormonal fluctuations while maintaining effective contraception.
Triphasic 28-day pack (EE 0.035 mg)
Days 1 — 7 — Norgestimate 0.180 mg / Ethinyl Estradiol 0.035 mg (white tablets); Days 8 — 14 — Norgestimate 0.215 mg / EE 0.035 mg (light blue tablets); Days 15 — 21 — Norgestimate 0.250 mg / EE 0.035 mg (blue tablets); Days 22 — 28 — Inert placebo tablets (dark green)
Low-dose triphasic (Ortho Tri-Cyclen Lo / Tri-Lo-Sprintec)
Same norgestimate phases but with Ethinyl Estradiol 0.025 mg instead of 0.035 mg
Ortho Tri-Cyclen 28 Day (brand) was discontinued by Janssen Pharmaceuticals, but its generic equivalents — including Tri-Sprintec, Tri-Estarylla, Tri-Previfem, Tri-Mili, and Tri-Linyah — are widely available at most pharmacies nationwide. There is no active FDA shortage for norgestimate/ethinyl estradiol triphasic tablets. Generic versions are manufactured by multiple companies (Teva, Lupin, Mylan, and others), ensuring robust supply. You should have little difficulty filling this prescription at any major chain or independent pharmacy.
Several types of healthcare providers can prescribe Ortho Tri-Cyclen 28 Day and its generic equivalents:
No, Ortho Tri-Cyclen 28 Day is not a controlled substance. It is not scheduled by the DEA. This means there are no special prescribing restrictions — your doctor can call in or electronically send your prescription, refills are straightforward, and there are no quantity limits imposed by federal regulation. Pharmacies can dispense it without the additional monitoring required for controlled medications.
Serious side effects (seek immediate medical attention): blood clots, stroke, heart attack, severe headache with vision changes, jaundice, or signs of liver problems. Important: Cigarette smoking significantly increases the risk of serious cardiovascular events, especially in women over 35.
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Tri-Sprintec
generic equivalent with identical active ingredients (norgestimate/ethinyl estradiol triphasic)
Tri-Estarylla
another generic equivalent with the same triphasic formulation
Tri-Previfem, Tri-Mili, Tri-Linyah, TriNessa
additional generic equivalents
Sprintec (Ortho-Cyclen generic)
monophasic version with a constant norgestimate 0.250 mg / EE 0.035 mg dose for all 21 active days
Tri-Lo-Sprintec (Ortho Tri-Cyclen Lo generic)
lower-dose triphasic with EE 0.025 mg instead of 0.035 mg
Prefer Ortho Tri-Cyclen 28 Day? We can find it.
Hepatitis C medications
moderate(ombitasvir/paritaprevir/ritonavir) — contraindicated
Rifampin
moderateand other TB medications — significantly reduces contraceptive efficacy
Anticonvulsants
moderate(phenytoin, carbamazepine, phenobarbital) — reduces efficacy
St. John's Wort
moderatereduces contraceptive effectiveness
HIV protease inhibitors and NNRTIs
moderatemay alter contraceptive levels
Bosentan
moderatemay reduce contraceptive efficacy
Tranexamic acid
moderateincreased risk of blood clots
Lamotrigine
moderateCOCs may decrease lamotrigine levels, potentially affecting seizure control
While the Ortho Tri-Cyclen brand has been discontinued, its generic equivalents remain among the most widely prescribed and easily accessible oral contraceptives in the United States. With multiple generic manufacturers, no active FDA shortage, and coverage under the ACA contraceptive mandate at $0 copay for most insured patients, finding and affording this medication should be straightforward. If you're having trouble locating a specific generic version, try Medfinder to check pharmacy stock near you, or ask your pharmacist about substituting an equivalent generic. For uninsured patients, discount cards can bring the cost as low as $6–$25 per pack.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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