Medications

Meprobamate

Meprobamate

Previously Found with Medfinder

Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.

Estimated Insurance Pricing
$15–$60 copay when covered; many plans require prior authorization or step therapy through Buspirone first.
Estimated Cash Pricing
$297–$671 retail for a 30-day supply; as low as $97–$158 with SingleCare or GoodRx coupons.
Medfinder Findability Score
45
/100
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Post Author

Peter Daggett

Last Updated

February 14, 2026

Meprobamate 2026 Availability, Prices, and Tips to Find

What Is Meprobamate?

Meprobamate is a carbamate-derivative anxiolytic (tranquilizer) approved by the FDA for the management of anxiety disorders and the short-term relief of anxiety symptoms. It was one of the first widely prescribed anti-anxiety medications, introduced in the 1950s under the brand names Miltown and Equanil. While it has largely been replaced by benzodiazepines and newer anxiolytics, some patients and providers still rely on Meprobamate when other treatments are not suitable. It is also a metabolite of Carisoprodol (Soma), a commonly prescribed muscle relaxant.

How does Meprobamate work?

The exact mechanism of action is not fully understood. Meprobamate is believed to act on multiple sites in the central nervous system, including the thalamus and limbic system, producing sedation and reducing anxiety. It has properties similar to barbiturates and enhances GABAergic activity, which decreases neuronal excitability. This results in a calming, anxiolytic effect. Because of its CNS depressant properties, it also carries a risk of physical dependence and should not be stopped abruptly after prolonged use.

What doses are available for Meprobamate?

  • 200 mg tablet — typically used for lower-dose regimens or pediatric patients (ages 6–12)
  • 400 mg tablet — the most commonly prescribed strength for adults
  • 600 mg tablet — used for higher-dose regimens as directed by a prescriber

All forms are oral tablets available as generics only. Brand-name versions (Miltown, Equanil, Meprospan) have been discontinued.

How hard is it to find Meprobamate in stock?

Meprobamate scores a 45 out of 100 on the Medfinder Findability Scale, meaning it can be moderately difficult to locate in stock. Brand names like Miltown and Equanil have been discontinued, and only a handful of generic manufacturers still produce it. Many retail pharmacies do not routinely stock Meprobamate, so you may need to call around or use Medfinder to check availability near you. Supply can vary significantly by region and pharmacy.

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Who Can Prescribe Meprobamate?

As a Schedule IV controlled substance, Meprobamate can be prescribed by any licensed prescriber with DEA authorization, including:

  • Psychiatrists — most commonly prescribe Meprobamate for anxiety disorders
  • Primary Care Physicians / Internists — may prescribe for patients already stabilized on the medication
  • Family Medicine Doctors — can prescribe when appropriate for anxiety management
  • Neurologists — rarely, in specific clinical scenarios

Note: Meprobamate is not available through telehealth prescribing services due to its controlled substance status and limited demand.

Is Meprobamate a controlled substance?

Yes. Meprobamate is classified as a DEA Schedule IV controlled substance, the same category as benzodiazepines like Lorazepam and Alprazolam. This means it has a recognized medical use but carries a risk of physical and psychological dependence. Prescriptions may be limited in refills, and pharmacies must follow controlled substance dispensing regulations. Patients should never share this medication or stop it abruptly — withdrawal can cause seizures and other serious symptoms.

Common Side Effects of Meprobamate

  • Drowsiness and sedation
  • Dizziness
  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Vision changes (blurred vision)
  • Weakness or fatigue
  • Excitement or paradoxical stimulation

Serious side effects that require immediate medical attention include severe allergic reactions (rash, hives, difficulty breathing), angioedema, irregular heartbeat, seizures (especially upon abrupt withdrawal), and blood dyscrasias. Contact your doctor or call 911 if you experience any of these symptoms.

Alternative Medications to Meprobamate

If you cannot find Meprobamate or your provider recommends switching, these alternatives may be considered:

  • Buspirone — a non-benzodiazepine anxiolytic with lower abuse potential; not a controlled substance in most states; used for generalized anxiety disorder
  • Hydroxyzine — an antihistamine with anxiolytic properties; not a controlled substance; commonly used for short-term anxiety relief
  • Lorazepam — a benzodiazepine (Schedule IV) widely used for anxiety with a better-understood safety profile
  • Alprazolam — a benzodiazepine (Schedule IV) commonly prescribed for anxiety and panic disorder

Always consult your prescriber before switching medications. Do not stop Meprobamate abruptly.

Drug Interactions with Meprobamate

Meprobamate interacts with several medications and substances. Always inform your prescriber of everything you take.

  • Alcohol — must be completely avoided; significantly increases CNS depression and overdose risk
  • Benzodiazepines (Lorazepam, Alprazolam, etc.) — additive sedation
  • Opioids — additive respiratory depression and sedation; potentially life-threatening
  • Barbiturates — additive CNS depression
  • Other CNS depressants — including antihistamines, antipsychotics, and sleep aids
  • MAO inhibitors — may enhance sedation
  • Anticonvulsants — may alter seizure threshold

Final Thoughts on Meprobamate

Meprobamate is an older but still-prescribed anxiolytic that can be moderately difficult to find at retail pharmacies due to limited manufacturing and the discontinuation of all brand-name versions. If you're struggling to locate it, Medfinder can help you check pharmacy availability near you without the hassle of calling around. Discount cards from SingleCare and GoodRx can reduce your cash price from over $600 down to under $160. Always work with your prescriber if you're having trouble filling your prescription — they can help explore alternatives or contact specialty pharmacies on your behalf.

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