Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Isentress (Raltegravir) is an antiretroviral medication manufactured by Merck & Co. that belongs to the Integrase Strand Transfer Inhibitor (INSTI) drug class. It is FDA-approved for the treatment of HIV-1 infection in adults and pediatric patients (from birth, weighing at least 2 kg) and is always used in combination with other antiretroviral agents. Isentress is also used off-label as part of post-exposure prophylaxis (PEP) regimens for HIV.
Raltegravir works by inhibiting the catalytic activity of HIV-1 integrase, an enzyme the virus needs to replicate. Integrase normally facilitates the integration of HIV-1 viral DNA into the host cell's genome. By blocking this critical step, Isentress prevents the virus from inserting its genetic material into your cells and multiplying, helping to reduce the viral load in your body and allowing your immune system to recover.
Isentress (Raltegravir) scores a 55 out of 100 on our findability scale, meaning it can sometimes be tricky to locate at your local pharmacy. While Isentress is not currently listed on the FDA or ASHP drug shortage lists as of early 2026, occasional supply disruptions at the pharmacy level can occur due to distribution logistics or insurance-related delays. Specialty pharmacies and HIV-focused clinics tend to keep more reliable stock. If your pharmacy is out, ask them to check their wholesaler or consider using Medfinder to locate nearby availability.
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Isentress is most commonly prescribed by Infectious Disease specialists and HIV Medicine specialists. However, Internal Medicine physicians, Family Medicine doctors, and Pediatric Infectious Disease specialists can also prescribe it. Telehealth consultations for HIV management are increasingly available, making it easier to obtain or renew prescriptions for Isentress remotely.
No, Isentress (Raltegravir) is not a controlled substance and does not have a DEA schedule classification. It does not carry any risk of abuse or dependence, so it can be prescribed and refilled without the additional restrictions that apply to controlled medications.
Serious but rare side effects include Stevens-Johnson syndrome, rhabdomyolysis, severe skin reactions, immune reconstitution inflammatory syndrome (IRIS), and elevated liver enzymes. Contact your healthcare provider immediately if you experience severe muscle pain, skin rashes, or signs of liver problems.
Isentress HD (600 mg) should always be taken with food for adequate absorption. The standard 400 mg tablets can be taken with or without food.
Isentress (Raltegravir) remains an important antiretroviral option for HIV-1 treatment, particularly for patients who need a well-tolerated INSTI with a long track record of safety, including in pregnancy and pediatric populations. While newer alternatives like Dolutegravir and Bictegravir have become preferred first-line options, Isentress continues to serve a vital role. At $1,900 to $2,500 per month without insurance, the cost can be significant, but Merck's copay savings card, patient assistance programs, and ADAP coverage can help reduce the financial burden. If you're having trouble finding Isentress in stock, try Medfinder to locate pharmacies near you that have it available.
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