Comprehensive medication guide to Imipramine including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
With insurance, Imipramine is typically covered as a Tier 1 generic with copays ranging from $0–$15 per month.
Estimated Cash Pricing
Generic Imipramine tablets cost $8–$50 for a 30-day supply without insurance, depending on dose and pharmacy.
Medfinder Findability Score
78/100
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Imipramine is a tricyclic antidepressant (TCA) that has been used since the late 1950s. It is FDA-approved for treating major depressive disorder in adults and nocturnal enuresis (bedwetting) in children aged 6 and older. Originally marketed as Tofranil by Novartis, it is now widely available as an affordable generic.
Beyond its approved uses, Imipramine is also prescribed off-label for panic disorder, chronic neuropathic pain, overactive bladder, PTSD, and anxiety disorders.
Imipramine works by blocking the reuptake of serotonin and norepinephrine at nerve endings in the brain, which increases the availability of these neurotransmitters and helps improve mood, anxiety, and pain signaling. It has a slightly higher affinity for the serotonin transporter than the norepinephrine transporter. Imipramine also has anticholinergic and antihistaminic properties, which contribute to some of its side effects such as dry mouth, drowsiness, and weight gain.
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Imipramine HCl Tablets
10 mg, 25 mg, 50 mg
Imipramine Pamoate Capsules (Tofranil-PM)
75 mg, 100 mg, 125 mg, 150 mg
Imipramine scores a 78 out of 100 on our findability scale, meaning it is generally available at most pharmacies. As a widely prescribed generic tricyclic antidepressant, Imipramine HCl tablets (10 mg, 25 mg, 50 mg) are stocked by most major retail and mail-order pharmacies. However, the Imipramine Pamoate capsule formulation (Tofranil-PM) can be harder to locate due to fewer manufacturers producing it. Sporadic regional supply gaps may occur for certain strengths, but most patients should be able to fill their prescriptions without significant difficulty.
Imipramine can be prescribed by a range of healthcare providers, including:
Telehealth providers can also prescribe Imipramine since it is not a controlled substance.
No. Imipramine is not classified as a controlled substance by the DEA. It does not have abuse potential like stimulants or benzodiazepines, and there are no special prescribing restrictions. This means it can be prescribed via telehealth, refilled without a new prescription each time, and transferred between pharmacies without additional regulatory hurdles.
Serious side effects include suicidal thoughts (especially in young adults under 25), cardiac arrhythmias, seizures, and serotonin syndrome. Imipramine carries an FDA boxed warning about increased risk of suicidal thinking in children, adolescents, and young adults. Contact your doctor immediately if you experience any serious side effects.
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Amitriptyline (Elavil)
another tricyclic antidepressant commonly used for depression and neuropathic pain
Nortriptyline (Pamelor)
a TCA metabolite of Amitriptyline with generally fewer side effects
Desipramine (Norpramin)
a TCA metabolite of Imipramine with more noradrenergic activity
Clomipramine (Anafranil)
a TCA used primarily for obsessive-compulsive disorder (OCD)
Prefer Imipramine? We can find it.
MAO Inhibitors
moderateDo not take within 14 days of an MAOI due to risk of hypertensive crisis and serotonin syndrome
SSRIs (Fluoxetine, Paroxetine)
moderateThese CYP2D6 inhibitors can significantly increase Imipramine blood levels
Cimetidine
moderateIncreases Imipramine levels
Clonidine
moderateImipramine may reduce Clonidine's blood pressure–lowering effect
Other anticholinergic drugs
moderateAdditive side effects like dry mouth, constipation, and urinary retention
CNS depressants (alcohol, benzodiazepines, opioids)
moderateIncreased sedation and respiratory depression risk
Grapefruit juice and St. John's Wort
moderateMay alter drug levels or increase serotonin syndrome risk
Imipramine is a well-established, affordable tricyclic antidepressant that remains an important treatment option for depression and childhood bedwetting. With a findability score of 78, most patients should be able to locate it without major issues, though the Pamoate capsule formulation may require more effort. Generic Imipramine tablets are among the most affordable antidepressants available, with cash prices as low as $8 with discount coupons and minimal insurance copays. If you're having trouble finding Imipramine at your local pharmacy, use Medfinder to search for availability near you.
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