Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Imipramine is a tricyclic antidepressant (TCA) that has been used since the late 1950s. It is FDA-approved for treating major depressive disorder in adults and nocturnal enuresis (bedwetting) in children aged 6 and older. Originally marketed as Tofranil by Novartis, it is now widely available as an affordable generic.
Beyond its approved uses, Imipramine is also prescribed off-label for panic disorder, chronic neuropathic pain, overactive bladder, PTSD, and anxiety disorders.
Imipramine works by blocking the reuptake of serotonin and norepinephrine at nerve endings in the brain, which increases the availability of these neurotransmitters and helps improve mood, anxiety, and pain signaling. It has a slightly higher affinity for the serotonin transporter than the norepinephrine transporter. Imipramine also has anticholinergic and antihistaminic properties, which contribute to some of its side effects such as dry mouth, drowsiness, and weight gain.
For depression, typical dosing ranges from 75–200 mg per day. For nocturnal enuresis in children aged 6 and older, the usual dose is 25–75 mg at bedtime.
Imipramine scores a 78 out of 100 on our findability scale, meaning it is generally available at most pharmacies. As a widely prescribed generic tricyclic antidepressant, Imipramine HCl tablets (10 mg, 25 mg, 50 mg) are stocked by most major retail and mail-order pharmacies. However, the Imipramine Pamoate capsule formulation (Tofranil-PM) can be harder to locate due to fewer manufacturers producing it. Sporadic regional supply gaps may occur for certain strengths, but most patients should be able to fill their prescriptions without significant difficulty.
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Imipramine can be prescribed by a range of healthcare providers, including:
Telehealth providers can also prescribe Imipramine since it is not a controlled substance.
No. Imipramine is not classified as a controlled substance by the DEA. It does not have abuse potential like stimulants or benzodiazepines, and there are no special prescribing restrictions. This means it can be prescribed via telehealth, refilled without a new prescription each time, and transferred between pharmacies without additional regulatory hurdles.
Serious side effects include suicidal thoughts (especially in young adults under 25), cardiac arrhythmias, seizures, and serotonin syndrome. Imipramine carries an FDA boxed warning about increased risk of suicidal thinking in children, adolescents, and young adults. Contact your doctor immediately if you experience any serious side effects.
If you cannot find or tolerate Imipramine, your doctor may consider the following alternatives:
Always talk to your prescriber before switching medications.
Imipramine has several important drug interactions to be aware of:
Imipramine is a well-established, affordable tricyclic antidepressant that remains an important treatment option for depression and childhood bedwetting. With a findability score of 78, most patients should be able to locate it without major issues, though the Pamoate capsule formulation may require more effort. Generic Imipramine tablets are among the most affordable antidepressants available, with cash prices as low as $8 with discount coupons and minimal insurance copays. If you're having trouble finding Imipramine at your local pharmacy, use Medfinder to search for availability near you.
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