Comprehensive medication guide to Cosopt including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
Generic Dorzolamide/Timolol is typically Tier 1 or 2 on most plans with copays of $0–$15; brand Cosopt may require prior authorization with copays of $30–$75.
Estimated Cash Pricing
Brand-name Cosopt costs $140–$220 for a 10 mL bottle; generic Dorzolamide/Timolol runs $10–$25 with discount coupons or $30–$80 at retail.
Medfinder Findability Score
75/100
Summarize with AI
On this page
Cosopt is a prescription combination eye drop used to treat elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It combines two active ingredients — Dorzolamide (a carbonic anhydrase inhibitor) and Timolol (a beta-blocker) — into a single convenient drop. Cosopt is typically prescribed for patients who need more IOP reduction than a single medication can provide, or who haven't responded adequately to beta-blockers alone. It is also sometimes used off-label for angle-closure glaucoma and secondary glaucoma.
![Why Is Cosopt So Hard to Find? [Explained for 2026]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F642b26e5aee4b4d3e07fc5a9dce8c2a4215c0f2a-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
![How to Find a Doctor Who Can Prescribe Cosopt Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2F5638b5c2195ada64558f71c09a69c7fa8295c4ee-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
We have a 99% success rate finding medications, even during nationwide shortages.
Need this medication?
Cosopt lowers intraocular pressure through two complementary mechanisms:
By targeting two different pathways simultaneously, Cosopt provides greater IOP reduction than either component alone. This dual mechanism helps protect the optic nerve from damage caused by elevated eye pressure.
Cosopt Ophthalmic Solution — ophthalmic
Dorzolamide 2% / Timolol 0.5% in a 10 mL bottle (contains preservative benzalkonium chloride)
Cosopt PF (Preservative-Free)
Dorzolamide 2% / Timolol 0.5% in single-use vials (for patients sensitive to preservatives)
Cosopt (Dorzolamide/Timolol) scores a 75 out of 100 on our findability scale, meaning it is generally available at most pharmacies with only minor gaps. The generic version is manufactured by several companies and is widely stocked. However, Cosopt has experienced periodic shortages historically — most notably in 2017–2018 when manufacturing delays affected multiple generic producers. The 2023 bankruptcy of Akorn, a major generic manufacturer, reduced the number of supply sources. As of early 2026, Cosopt is not on the FDA Drug Shortage List, but sporadic availability issues have been reported by patients. If your local pharmacy is out of stock, Medfinder can help you locate pharmacies that have it available near you.
Cosopt is most commonly prescribed by:
Telehealth prescribing is generally not available for Cosopt since glaucoma diagnosis requires in-person eye exams with specialized equipment (tonometry, visual field testing, and optic nerve imaging).
No, Cosopt is not a controlled substance. It has no DEA scheduling and no potential for abuse or dependence. You can transfer prescriptions between pharmacies without restrictions and obtain refills through standard prescription processes. This makes it easier to shop around for the best price or find it in stock at a different pharmacy if your usual one is out.
Serious side effects are less common but may include bronchospasm (especially in patients with asthma or COPD), slow heart rate, severe allergic reactions, corneal erosion, and mood changes. Contact your doctor immediately if you experience difficulty breathing, chest pain, or swelling of the face or throat.
Know what you need? Skip the search.
Combigan
(Brimonidine/Timolol) — another combination eye drop that pairs a beta-blocker with an alpha agonist instead of a carbonic anhydrase inhibitor
Simbrinza
(Brinzolamide/Brimonidine) — a beta-blocker-free combination for patients who cannot tolerate Timolol
Latanoprost (Xalatan)
a prostaglandin analog and common first-line monotherapy for glaucoma
Rocklatan
(Netarsudil/Latanoprost) — a newer combination drop that targets different IOP-lowering pathways
Prefer Cosopt? We can find it.
Oral beta-blockers
moderate(e.g., Metoprolol, Atenolol) — additive beta-blocking effects increasing risk of hypotension and bradycardia
Calcium channel blockers
moderate(e.g., Verapamil, Diltiazem) — additive cardiac effects and risk of AV conduction problems
Oral carbonic anhydrase inhibitors
moderate(e.g., Acetazolamide) — additive effects; combination not recommended
Catecholamine-depleting drugs
moderate(e.g., Reserpine) — additive hypotension and bradycardia
CYP2D6 inhibitors
moderate(e.g., Quinidine, SSRIs like Fluoxetine) — may increase systemic Timolol levels
Clonidine
moderaterisk of rebound hypertension if Clonidine is discontinued
Injectable Epinephrine
moderatemay be less effective for anaphylaxis treatment while on beta-blockers
Cosopt remains a valuable and widely used treatment for glaucoma and ocular hypertension in 2026. The generic version (Dorzolamide/Timolol) is affordable — often under $25 with discount coupons — and is stocked at most major pharmacies. While periodic supply disruptions can occur, the medication is not currently in shortage. If you're having trouble finding Cosopt at your local pharmacy, try Medfinder to quickly check real-time availability at pharmacies near you. For patients on a tight budget, manufacturer patient assistance programs and discount cards from GoodRx or SingleCare can significantly reduce out-of-pocket costs.
Medfinder Editorial Standards
Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
ChatGPT
Claude
Perplexity
Grok
Gemini